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Title: Nucleic acid detection system and method for detecting influenza


The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic acid detection system suitable for highly sensitive pathogen detection. Hybridization to single-stranded DNA amplification products using the system of the invention provides a sensitive and specific means by which assays can be multiplexed for the detection of multiple target sequences.

Issue Date:
Research Org.:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org.:
OSTI Identifier:
Patent Number(s):
Application Number:
Los Alamos National Security, LLC. (Los Alamos, NM)
DOE Contract Number:  
Resource Type:
Resource Relation:
Patent File Date: 2007 Aug 22
Country of Publication:
United States

Citation Formats

Cai, Hong, and Song, Jian. Nucleic acid detection system and method for detecting influenza. United States: N. p., 2015. Web.
Cai, Hong, & Song, Jian. Nucleic acid detection system and method for detecting influenza. United States.
Cai, Hong, and Song, Jian. Tue . "Nucleic acid detection system and method for detecting influenza". United States.
title = {Nucleic acid detection system and method for detecting influenza},
author = {Cai, Hong and Song, Jian},
abstractNote = {The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic acid detection system suitable for highly sensitive pathogen detection. Hybridization to single-stranded DNA amplification products using the system of the invention provides a sensitive and specific means by which assays can be multiplexed for the detection of multiple target sequences.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {3}


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