Nucleic acid detection system and method for detecting influenza

Title: Nucleic acid detection system and method for detecting influenza

The invention provides a rapid, sensitive and specific nucleic acid detection system which utilizes isothermal nucleic acid amplification in combination with a lateral flow chromatographic device, or DNA dipstick, for DNA-hybridization detection. The system of the invention requires no complex instrumentation or electronic hardware, and provides a low cost nucleic acid detection system suitable for highly sensitive pathogen detection. Hybridization to single-stranded DNA amplification products using the system of the invention provides a sensitive and specific means by which assays can be multiplexed for the detection of multiple target sequences.

Inventors:: Cai, Hong; Song, Jian

Issue Date:: 2015-03-17

OSTI Identifier:: 1172753

Assignee:: Los Alamos National Security, LLC. (Los Alamos, NM) LANL

Patent Number(s):: 8,980,561

Application Number:: 11/894,908

Contract Number:: AC52-06NA25396

Resource Relation:: Patent File Date: 2007 Aug 22

Research Org:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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