Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
Abstract
A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.
- Inventors:
- Issue Date:
- Research Org.:
- Idaho National Laboratory (INL), Idaho Falls, ID (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1171695
- Patent Number(s):
- 8969009
- Application Number:
- 12/586,109
- Assignee:
- IDO
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- AC07-05ID14517
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2009 Sep 17
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, and Apel, William A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States: N. p., 2015.
Web.
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, & Apel, William A. Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual. United States.
Thompson, Vicki S, Lacey, Jeffrey A, Gentillon, Cynthia A, and Apel, William A. Tue .
"Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual". United States. https://www.osti.gov/servlets/purl/1171695.
@article{osti_1171695,
title = {Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual},
author = {Thompson, Vicki S and Lacey, Jeffrey A and Gentillon, Cynthia A and Apel, William A},
abstractNote = {A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {3}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Peptides on phage: a vast library of peptides for identifying ligands
journal, August 1990
- Cwirla, S. E.; Peters, E. A.; Barrett, R. W.
- Proceedings of the National Academy of Sciences, Vol. 87, Issue 16, p. 6378-6382
Random peptide libraries: a source of specific protein binding molecules
journal, July 1990
- Devlin, J.; Panganiban, L.; Devlin, P.
- Science, Vol. 249, Issue 4967
DNA SEQUENCING: Massively Parallel Genomics
journal, July 1997
- Fodor, S. P.
- Science, Vol. 277, Issue 5324
Antibody Fingerprinting: A Novel Method for Identifying Individual People and Animals
journal, July 1988
- Francoeur, Ann-Michele
- Nature Biotechnology, Vol. 6, Issue 7
Detection of analyte binding to microarrays using gold nanoparticle labels and a desktop scanner
journal, September 2003
- Han, Anpan; Dufva, Martin; Belleville, Erik
- Lab on a Chip, Vol. 3, Issue 4, p. 329-332
A new type of synthetic peptide library for identifying ligand-binding activity
journal, November 1991
- Lam, Kit S.; Salmon, Sydney E.; Hersh, Evan M.
- Nature, Vol. 354, Issue 6348
Electrogenerated Chemiluminescence: An Oxidative-Reduction Type ECL Reaction Sequence Using Tripropyl Amine
journal, January 1990
- Leland, Jonathan K.; Powell, Michael J.
- Journal of The Electrochemical Society, Vol. 137, Issue 10, p. 3127-3131
Microarray technology: the future of blood testing?
journal, January 2001
- Petrik, J.
- Vox Sanguinis, Vol. 80, Issue 1
Cloning of open reading frames and promoters from the Saccharomyces cerevisiae genome: construction of genomic libraries of random small fragments
journal, January 1986
- Santangelo, George M.; Tornow, Joanne; Moldave, Kivie
- Gene, Vol. 46, Issue 2-3, p. 181-186
Searching for peptide ligands with an epitope library
journal, July 1990
- Scott, J.; Smith, G.
- Science, Vol. 249, Issue 4967
Antibody profiling as an identification tool for forensic samples
conference, February 1999
- Thompson, Vicki S.; Barrett, Karen B.; Davis, Tilton
- Enabling Technologies for Law Enforcement and Security, vp.
Fiber-Optic Immunosensor for the Detection of Fumonisin B1
journal, April 1996
- Thompson, Vicki S.; Maragos, Chris M.
- Journal of Agricultural and Food Chemistry, Vol. 44, Issue 4, p. 1041-1046
Yeast RNA polymerase II genes: isolation with antibody probes
journal, November 1983
- Young, R.; Davis, R.
- Science, Vol. 222, Issue 4625
Difference gel electrophoresis. A single gel method for detecting changes in protein extracts
journal, January 1997
- Ünlü, Mustafa; Morgan, Mary E.; Minden, Jonathan S.
- Electrophoresis, Vol. 18, Issue 11, p. 2071-2077
Preliminary Investigations into Tris(2,2'-bipyridyl) Ruthenium (III) as a Chemiluminescent Reagent for the Detection of 3,6-Diacetylmorphine (Heroin) on Surfaces
journal, September 2007
- Agg, Kent M.; Barnett, Neil W.; Lewis, Simon W.
- Journal of Forensic Sciences, Vol. 52, Issue 5, p. 1111-1114
Micromosaic Immunoassays
journal, November 2000
- Bernard, André; Michel, Bruno; Delamarche, Emmanuel
- Analytical Chemistry, Vol. 73, Issue 1, p. 8-12
Athletic drug Testing
journal, April 1998
- Bowers, Larry D.
- Clinics in Sports Medicine, Vol. 17, Issue 2
Sensitivity of Two Enzyme-linked Immunosorbent Assay Tests in Relation to Western Blot in Detecting Human T-Cell Lymphotropic Virus Types I and II Infection among HIV-1 Infected Patients from São Paulo, Brazil
journal, March 1998
- Caterino-de-Araujo, Adele; de los Santos-Fortuna, Elizabeth; Meleiro, Mônica Cristina Zandoná
- Diagnostic Microbiology and Infectious Disease, Vol. 30, Issue 3, p. 173-182
Saliva Testing for Drugs of Abuse
journal, September 1993
- Cone, Edward J.
- Annals of the New York Academy of Sciences, Vol. 694, Issue 1, p. 91-127
Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale
journal, October 1997
- DeRisi, J. L.; Iyer, Vishwanath R.; Brown, Patrick O.
- Science, Vol. 278, Issue 5338, p. 680-686
Automatic multiparameter fluorescence imaging for determining lymphocyte phenotype and activation status in melanoma tissue sections
journal, September 1996
- Dow, Alasdair I.; Shafer, Steven A.; Kirkwood, John M.
- Cytometry, Vol. 25, Issue 1, p. 71-81
Testing for drugs of abuse in saliva and sweat
journal, August 1998
- Kidwell, David A.; Holland, Janel C.; Athanaselis, Sotiris
- Journal of Chromatography B: Biomedical Sciences and Applications, Vol. 713, Issue 1, p. 111-135
Antibody Arrays: Technical Considerations and Clinical Applications in Cancer
journal, September 2006
- Sanchez-Carbayo, M.
- Clinical Chemistry, Vol. 52, Issue 9
Drugs of Abuse in Saliva: A Review
journal, January 1992
- Schramm, W.; Smith, R. H.; Craig, P. A.
- Journal of Analytical Toxicology, Vol. 16, Issue 1, p. 1-9
Multilayer peroxidase-labeled antibody method: Comparison with labeled streptavidin-biotin method, avidin-biotin-peroxidase complex method, and peroxidase-antiperoxidase method
journal, January 1995
- Shin, Masashi; Izumi, Shin-Ichi; Nakane, Paul K.
- Journal of Clinical Laboratory Analysis, Vol. 9, Issue 6, p. 424-430
Multiple-reaction cycling: a method for enhancement of the immunochemical signal of monoclonal antibodies.
journal, August 1988
- Linsenmayer, T. F.; Fitch, J. M.; Schmid, T. M.
- Journal of Histochemistry & Cytochemistry, Vol. 36, Issue 8
Detection protocols for biotinylated probes: optimization using multistep techniques.
journal, April 1992
- McQuaid, S.; Allan, G. M.
- Journal of Histochemistry & Cytochemistry, Vol. 40, Issue 4
Rapid Detection and Enumeration of Legionella pneumophila in Hot Water Systems by Solid-Phase Cytometry
journal, March 2004
- Aurell, H.; Catala, P.; Farge, P.
- Applied and Environmental Microbiology, Vol. 70, Issue 3, p. 1651-1657
A novel immunohistochemical technique for demonstration of specific binding of human monoclonal antibodies to human cryostat tissue sections.
journal, July 1990
- Tuson, J. R.; Pascoe, E. W.; Jacob, D. A.
- Journal of Histochemistry & Cytochemistry, Vol. 38, Issue 7
Primary Antibody–Fab Fragment Complexes: A Flexible Alternative to Traditional Direct and Indirect Immunolabeling Techniques
journal, September 2004
- Brown, Jeremy K.; Pemberton, Alan D.; Wright, Steven H.
- Journal of Histochemistry & Cytochemistry, Vol. 52, Issue 9
Protein microarrays for highly parallel detection and quantitation of specific proteins and antibodies in complex solutions
journal, January 2001
- Haab, Brian B.; Dunham, Maitreya J.; Brown, Patrick O.
- Genome Biology, Vol. 2, Issue 2, Article No. research0004.1
Pattern Recognition in Pulmonary Tuberculosis Defined by High Content Peptide Microarray Chip Analysis Representing 61 Proteins from M. tuberculosis
journal, December 2008
- Gaseitsiwe, Simani; Valentini, Davide; Mahdavifar, Shahnaz
- PLoS ONE, Vol. 3, Issue 12, Article No. e3840
Protein microarrays: Molecular profiling technologies for clinical specimens
journal, November 2003
- Espina, Virginia; Mehta, Arpita I.; Winters, Mary E.
- PROTEOMICS, Vol. 3, Issue 11
Assay employing a labeled Fab-fragment ligand complex
patent, November 1980
- Schwarzberg, Moshe
- US Patent Document 4,235,869
Phycobiliprotein fluorescent conjugates
patent, September 1985
- Stryer, Lubert; Glazer, Alexander N.
- US Patent Document 4,542,104
Individual-specific antibody identification methods
patent, November 1989
- Francoeur, Ann-Michele
- US Patent Document 4,880,750
Analytical test devices for competition assay for drugs of non-protein antigens using immunochromatographic techniques
patent, August 1993
- Sun, Ming; Pfeiffer, Francis R.
- US Patent Document 5,238,652
Methods of identification employing antibody profiles
patent, December 1993
- Francoeur, Ann-Michele
- US Patent Document 5,270,167
Modified avidin-biotin technique
patent, January 1994
- Trojanowski, John Q.; Lee, Virginia Man-Yee
- US Patent Document 5,281,521
Array of oligonucleotides on a solid substrate
patent, August 1995
- Fodor, Stephen P. A.; Pirrung, Michael C.; Read, J. Leighton
- US Patent Document 5,445,934
Method of detecting and correcting a direction of image data and document image filing system employing the same
patent, November 1995
- Kurosu, Yasuo; Masuzaki, Hidefumi; Fujisawa, Hiromichi
- US Patent Document 5,471,549
Anti-idiotypic monoclonal antibody that induces an immune response against the ganglioside GD.sub.3 and hybridoma producing said antibody
patent, June 1996
- Chapman, Paul; Houghton, Alan
- US Patent Document 5,529,922
Method for detecting an analyte using an electrochemical luminescent transition metal label
patent, July 1996
- Siddigi, Iqbal W.; Sternberg, James C.
- US Patent Document 5,541,113
Active programmable electronic devices for molecular biological analysis and diagnostics
patent, February 1997
- Heller, Michael J.; Tu, Eugene
- US Patent Document 5,605,662
Arrays of materials attached to a substrate
patent, April 1998
- Fodor, Stephen P. A.; Stryer, Lubert; Read, J. Leighton
- US Patent Document 5,744,305
Patterning antibodies on a surface
patent, January 1999
- Brizzolara, Robert A.
- US Patent Document 5,858,801
Method of obtaining small conformationally rigid conopeptides
patent, March 1999
- Olivera, Baldomero M.; Hillyard, David R.; Myers, Richard A.
- US Patent Document 5,885,780
Monoclonal antibodies against human pancreatic islet cells
patent, March 1999
- Endl, Josef; Brandt, Michael; Jungfer, Herbert
- US Patent Document 5,888,813
Miniaturized cell array methods and apparatus for cell-based screening
patent, August 2000
- Taylor, D. Lansing
- US Patent Document 6,103,479
Method and apparatus for automated image analysis of biological specimens
patent, April 2003
- Douglass, James W.; Riding, Thomas J.; Ring, James E.
- US Patent Document 6,553,135
Method and apparatus for acquiring offset checkshot survey data using tube-wave conversion
patent, July 2003
- Krebs, Jerome R.; Chen, Sen-Tsuen
- US Patent Document 6,591,193
Method and system for extracting data from surface array deposited features
patent, July 2003
- Yakhini, Zohar; Enderwick, Cynthia Y.; Delenstarr, Glenda
- US Patent Document 6,591,196
Aminediols for the treatment of Alzheimer's disease
patent, June 2005
- Schostarez, Heinrich J.; Chrusciel, Robert A.
- US Patent Document 6,906,104
System, method, and computer software product for grid alignment of multiple scanned images
patent, November 2005
- Kaushikkar, Shantanu; Patil, Sangita B.
- US Patent Document 6,965,704
Method, system, and computer code for finding spots defined in biological microarrays
patent, December 2005
- Niles, Richard K.; Martens, Christine L.; Foskett, Darach B.
- US Patent Document 6,980,677
Rapid classification of biological components
patent, January 2006
- Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.
- US Patent Document 6,989,276
Systems and methods for automated analysis of cells and tissues
patent, May 2007
- Rimm, David L.; Camp, Robert L.
- US Patent Document 7,219,016
Rapid classification of biological components
patent, March 2010
- Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.
- US Patent Document 7,682,797
Rapid classification of biological components
patent, March 2010
- Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.
- US Patent Document 7,682,798
Antibody profiling sensitivity through increased reporter antibody layering
patent, April 2010
- Apel, William A.; Thompson, Vicki S.
- US Patent Document 7,695,919
Micro-array analysis system and method thereof
patent, September 2011
- Bouchard, Jean-Pierre; Claveau, Fabien; Noiseux, Isabelle
- US Patent Document 8,014,577
Antibody profiling sensitivity through increased reporter antibody layering
patent, February 2013
- Apel, William A.; Thompson, Vicki S.
- US Patent Document RE44,031
Rapid classification of biological components
patent, October 2013
- Thompson, Vicki S.; Barrett, Karen B.; Key, Diane E.
- US Patent Document RE44,539
Method and system for processing regions of interest for objects comprising biological material
patent-application, May 2004
- Kallioniemi, Olli P.; Pohida, Thomas J.; Karareka, John
- US Patent Application 10/450372; 20040085443
Image change detection systems, methods, and articles of manufacture
patent-application, March 2005
- Jones, James L.; Lassahn, Gordon D.; Lancaster, Gregory D.
- US Patent Application 10/655467; 20050047678
Biological systems analysis
patent-application, June 2006
- Afeyan, Noubar; Adourian, Aram; Handzel, Amir A.
- US Patent Application10/999512; 20060115429
Abeta antibodies for use in improving cognition
patent-application, November 2006
- Jacobsen, Jack Steven
- US Patent Application 11/305899; 20060257396
Works referencing / citing this record:
Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual
patent, August 2016
- Apel, William A.; Thompson, Vicki S.; Lacey, Jeffrey A.
- US Patent Document 9,410,965