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Title: Alteration and modulation of protein activity by varying post-translational modification

Abstract

Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.

Inventors:
; ; ; ;
Issue Date:
Research Org.:
Idaho National Lab. (INL), Idaho Falls, ID (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1171694
Patent Number(s):
8969033
Application Number:
12/655,993
Assignee:
Battelle Energy Alliance, LLC (Idaho Falls, ID)
Patent Classifications (CPCs):
Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02P - CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
AC07-99ID13727
Resource Type:
Patent
Resource Relation:
Patent File Date: 2010 Jan 12
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Thompson, David N, Reed, David W, Thompson, Vicki S, Lacey, Jeffrey A, and Apel, William A. Alteration and modulation of protein activity by varying post-translational modification. United States: N. p., 2015. Web.
Thompson, David N, Reed, David W, Thompson, Vicki S, Lacey, Jeffrey A, & Apel, William A. Alteration and modulation of protein activity by varying post-translational modification. United States.
Thompson, David N, Reed, David W, Thompson, Vicki S, Lacey, Jeffrey A, and Apel, William A. Tue . "Alteration and modulation of protein activity by varying post-translational modification". United States. https://www.osti.gov/servlets/purl/1171694.
@article{osti_1171694,
title = {Alteration and modulation of protein activity by varying post-translational modification},
author = {Thompson, David N and Reed, David W and Thompson, Vicki S and Lacey, Jeffrey A and Apel, William A},
abstractNote = {Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {3}
}

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