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Title: Study of polymer molecules and conformations with a nanopore

The invention features methods for evaluating the conformation of a polymer, for example, for determining the conformational distribution of a plurality of polymers and to detect binding or denaturation events. The methods employ a nanopore which the polymer, e.g., a nucleic acid, traverses. As the polymer traverses the nanopore, measurements of transport properties of the nanopore yield data on the conformation of the polymer.
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OSTI Identifier:
President and Fellows of Harvard College (Cambridge, MA) CHO
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Resource Relation:
Patent File Date: 2013 Feb 13
Research Org:
President and Fellows of Harvard College, Cambridge, MA (United States)
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Country of Publication:
United States

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