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Title: Expanding the eukaryotic genetic code

Abstract

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.

Inventors:
; ; ;
Issue Date:
Research Org.:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1169093
Patent Number(s):
8945926
Application Number:
13/329,202
Assignee:
The Scripps Research Institute (La Jolla, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
DOE Contract Number:  
FG0300ER45812
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Chin, Jason W, Cropp, T. Ashton, Anderson, J. Christopher, and Schultz, Peter G. Expanding the eukaryotic genetic code. United States: N. p., 2015. Web.
Chin, Jason W, Cropp, T. Ashton, Anderson, J. Christopher, & Schultz, Peter G. Expanding the eukaryotic genetic code. United States.
Chin, Jason W, Cropp, T. Ashton, Anderson, J. Christopher, and Schultz, Peter G. Tue . "Expanding the eukaryotic genetic code". United States. https://www.osti.gov/servlets/purl/1169093.
@article{osti_1169093,
title = {Expanding the eukaryotic genetic code},
author = {Chin, Jason W and Cropp, T. Ashton and Anderson, J. Christopher and Schultz, Peter G},
abstractNote = {This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {2}
}

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