Personal glucose meters for detection and quantification of a broad range of analytes

Lu, Yi; Xiang, Yu

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Title: Personal glucose meters for detection and quantification of a broad range of analytes

Abstract

A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules that are specific for a target agent, enzymes that can convert an enzyme substrate into glucose, and PGM. Also provided are sensors, which can include a solid support to which is attached a recognition molecule that permits detection of a target agent, wherein the recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents as well as an enzyme that can catalyze the conversion of a substance into glucose, wherein the enzyme is attached directly or indirectly to the recognition molecule, and wherein in the presence of the target agent the enzyme can convert the substance into glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents are also provided.

Inventors:: Lu, Yi; Xiang, Yu

Issue Date:: 2015-02-03

Research Org.:: Univ. of Illinois at Urbana-Champaign, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1169090

Patent Number(s):: 8945943

Application Number:: 13/699,578

Assignee:: The Board of Trustees of the University of Illinois (Urbana, IL)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Show more

C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
C12Q1/34 - involving hydrolase
C12Q1/54 - involving glucose or galactose

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N33/558 - using diffusion or migration of antigen or antibody

Show less

DOE Contract Number:: FG02-08ER64568

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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                    Lu, Yi, and Xiang, Yu. Personal glucose meters for detection and quantification of a broad range of analytes.  United States: N. p., 2015. 
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                    Lu, Yi, & Xiang, Yu. Personal glucose meters for detection and quantification of a broad range of analytes.  United States.

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                    Lu, Yi, and Xiang, Yu. Tue .  
        "Personal glucose meters for detection and quantification of a broad range of analytes".  United States.  https://www.osti.gov/servlets/purl/1169090.

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@article{osti_1169090,

  title        = {Personal glucose meters for detection and quantification of a broad range of analytes},

  author       = {Lu, Yi and Xiang, Yu},

  abstractNote = {A general methodology for the development of highly sensitive and selective sensors that can achieve portable, low-cost and quantitative detection of a broad range of targets using only a personal glucose meter (PGM) is disclosed. The method uses recognition molecules that are specific for a target agent, enzymes that can convert an enzyme substrate into glucose, and PGM. Also provided are sensors, which can include a solid support to which is attached a recognition molecule that permits detection of a target agent, wherein the recognition molecule specifically binds to the target agent in the presence of the target agent but not significantly to other agents as well as an enzyme that can catalyze the conversion of a substance into glucose, wherein the enzyme is attached directly or indirectly to the recognition molecule, and wherein in the presence of the target agent the enzyme can convert the substance into glucose. The disclosed sensors can be part of a lateral flow device. Methods of using such sensors for detecting target agents are also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {2}

}

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Journal of the American Chemical Society, Vol. 131, Issue 20
https://doi.org/10.1021/ja901315w

Thermostable α-Amylase Conjugated Antibodies as Probes for Immunodetection in Elisa
journal, August 2002

Nanda, Sarita; Muralidhar, K.; Kar, S. K.
Journal of Immunoassay and Immunochemistry, Vol. 23, Issue 3
https://doi.org/10.1081/IAS-120013032

Chemiluminescent enzyme immunoassay A review.
journal, January 1989

Tsuji, Akio; Maeda, Masako; Arakawa, Hidetoshi
Analytical Sciences, Vol. 5, Issue 5
https://doi.org/10.2116/analsci.5.497

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Title: Personal glucose meters for detection and quantification of a broad range of analytes

Abstract

Citation Formats

Cascade amplification enzyme immunoassay patent, July 1984

Theophylline immunogens, antibodies, labeled conjugates, and related derivatives patent, August 1985

Sheet-like diagnostic device patent, August 1989

Reversible immobilization of assay reagents in a multizone test device patent, September 1990

Biosensor containing immobilized Zymomonas mobilis cells for measuring glucose, fructose and sucrose patent, January 1993

One-step competitive immunoassay for the semiquantitative determination of plasma lipoprotein(a) patent, July 1993

Method for determining chondrocalcin patent, December 1994

Cellular Responses to Interferon-γ journal, April 1997

A DNA enzyme that cleaves RNA journal, December 1994

Engineered allosteric ribozymes as biosensor components journal, February 2002

Biochemical Characterization of a Uranyl Ion-Specific DNAzyme journal, February 2009

In vitro selection of self-cleaving DNAs journal, December 1996

Selective recognition of metal ions by metalloregulatory proteins journal, April 2008

Magnetic Modulation Biosensing for Rapid and Homogeneous Detection of Biological Targets at Low Concentrations journal, January 2010

Electrochemical DNA sensors journal, October 2003

In vitro selection of RNA molecules that bind specific ligands journal, August 1990

Supramolecular Cocaine−Aptamer Complexes Activate Biocatalytic Cascades journal, April 2009

Aptamer-Modified Gold Nanoparticles for Colorimetric Determination of Platelet-Derived Growth Factors and Their Receptors journal, September 2005

A DNA Aptamer That Binds Adenosine and ATP journal, January 1995

Aptamer Database journal, January 2004

Colorimetric Detection of Mercuric Ion (Hg2+) in Aqueous Media using DNA-Functionalized Gold Nanoparticles journal, May 2007

Over-the-Counter Biosensors: Past, Present, and Future journal, September 2008

Highly Sensitive and Selective Colorimetric Sensors for Uranyl (UO 2 2+ ): Development and Comparison of Labeled and Label-Free DNAzyme-Gold Nanoparticle Systems journal, October 2008

A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles journal, June 2003

Colorimetric Biosensors Based on DNAzyme-Assembled Gold Nanoparticles journal, July 2004

Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles journal, January 2006

Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles journal, January 2006

A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity journal, February 2007

Development of a Monoclonal Antibody against Ochratoxin A and Its Application in Enzyme-Linked Immunosorbent Assay and Gold Nanoparticle Immunochromatographic Strip journal, September 2008

Functional Nucleic Acid Sensors journal, May 2009

A Simple and Sensitive “Dipstick” Test in Serum Based on Lateral Flow Separation of Aptamer-Linked Nanostructures journal, December 2006

Overview on self-monitoring of blood glucose journal, April 2009

Nucleic acid aptamers and enzymes as sensors journal, June 2006

Array Biosensor for Detection of Ochratoxin A in Cereals and Beverages journal, January 2005

The developments of semisynthetic DNA–protein conjugates journal, September 2002

Functional devices from DNA and proteins journal, April 2007

Functional devices from DNA and proteins journal, April 2007

Tools and Tactics for the Optical Detection of Mercuric Ion journal, September 2008

Structure-Switching Signaling Aptamers journal, April 2003

In Vitro Selection of Structure-Switching Signaling Aptamers journal, February 2005

Aptamers with fluorescence-signaling properties journal, September 2005

Highly Selective Oligonucleotide-Based Sensor for Mercury(II) in Aqueous Solutions journal, August 2004

Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review journal, December 2004

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans journal, January 2007

Ochratoxin A: A review (Technical Report) journal, January 1992

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging journal, May 2008

Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine journal, January 2010

Selecting Nucleic Acids for Biosensor Applications journal, June 2002

Studies on Identifying the Catalytic Role of Glu-204 in the Active Site of Yeast Invertase journal, June 1996

Nucleic acid aptamers for biosensors and bio-analytical applications journal, January 2009

Aptamer-based biosensors journal, February 2008

Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based Sensor journal, April 2009

Magnetic labeling, detection, and system integration journal, September 2008

Molecular beacons journal, October 2004

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase journal, August 1990

Development of an Aptamer Beacon for Detection of Interferon-Gamma journal, March 2010

Magnetic bead-based label-free journal, October 2001

Metal Nanoparticle-Based Electrochemical Stripping Potentiometric Detection of DNA Hybridization journal, November 2001

Carbon Nanotube/Teflon Composite Electrochemical Sensors and Biosensors journal, March 2003

Electronic Aptamer-Based Sensors journal, August 2007

Terminal Protection of Small-Molecule-Linked DNA for Sensitive Electrochemical Detection of Protein Binding via Selective Carbon Nanotube Assembly journal, September 2009

Abasic Site-Containing DNAzyme and Aptamer for Label-Free Fluorescent Detection of Pb 2+ and Adenosine with High Sensitivity, Selectivity, and Tunable Dynamic Range journal, October 2009

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets journal, July 2011

Using Commercially Available Personal Glucose Meters for Portable Quantification of DNA journal, January 2012

Portable and Quantitative Detection of Protein Biomarkers and Small Molecular Toxins Using Antibodies and Ubiquitous Personal Glucose Meters journal, April 2012

Electrochemical Detection of Parts-Per-Billion Lead via an Electrode-Bound DNAzyme Assembly journal, January 2007

Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification journal, September 2009

One-Step, Room Temperature, Colorimetric Detection of Mercury (Hg 2+ ) Using DNA/Nanoparticle Conjugates journal, March 2008

MRI Detection of Thrombin with Aptamer Functionalized Superparamagnetic Iron Oxide Nanoparticles journal, February 2008

Comparison of Enzyme-Linked Immunosorbent Assays with Chemiluminescent and Colorimetric Detection for the Determination of Ochratoxin A in Food journal, February 2011

Design of Gold Nanoparticle-Based Colorimetric Biosensing Assays journal, October 2008

A Target-Responsive Electrochemical Aptamer Switch (TREAS) for Reagentless Detection of Nanomolar ATP journal, February 2007

High Specificity, Electrochemical Sandwich Assays Based on Single Aptamer Sequences and Suitable for the Direct Detection of Small-Molecule Targets in Blood and Other Complex Matrices journal, May 2009

Thermostable α-Amylase Conjugated Antibodies as Probes for Immunodetection in Elisa journal, August 2002

Chemiluminescent enzyme immunoassay A review. journal, January 1989

Cascade amplification enzyme immunoassay
patent, July 1984

Theophylline immunogens, antibodies, labeled conjugates, and related derivatives
patent, August 1985

Sheet-like diagnostic device
patent, August 1989

Reversible immobilization of assay reagents in a multizone test device
patent, September 1990

Biosensor containing immobilized Zymomonas mobilis cells for measuring glucose, fructose and sucrose
patent, January 1993

One-step competitive immunoassay for the semiquantitative determination of plasma lipoprotein(a)
patent, July 1993

Method for determining chondrocalcin
patent, December 1994

Cellular Responses to Interferon-γ
journal, April 1997

A DNA enzyme that cleaves RNA
journal, December 1994

Engineered allosteric ribozymes as biosensor components
journal, February 2002

Biochemical Characterization of a Uranyl Ion-Specific DNAzyme
journal, February 2009

In vitro selection of self-cleaving DNAs
journal, December 1996

Selective recognition of metal ions by metalloregulatory proteins
journal, April 2008

Magnetic Modulation Biosensing for Rapid and Homogeneous Detection of Biological Targets at Low Concentrations
journal, January 2010

Electrochemical DNA sensors
journal, October 2003

In vitro selection of RNA molecules that bind specific ligands
journal, August 1990

Supramolecular Cocaine−Aptamer Complexes Activate Biocatalytic Cascades
journal, April 2009

Aptamer-Modified Gold Nanoparticles for Colorimetric Determination of Platelet-Derived Growth Factors and Their Receptors
journal, September 2005

A DNA Aptamer That Binds Adenosine and ATP
journal, January 1995

Aptamer Database
journal, January 2004

Colorimetric Detection of Mercuric Ion (Hg²⁺) in Aqueous Media using DNA-Functionalized Gold Nanoparticles
journal, May 2007

Over-the-Counter Biosensors: Past, Present, and Future
journal, September 2008

Highly Sensitive and Selective Colorimetric Sensors for Uranyl (UO ₂ ²⁺ ): Development and Comparison of Labeled and Label-Free DNAzyme-Gold Nanoparticle Systems
journal, October 2008

A Colorimetric Lead Biosensor Using DNAzyme-Directed Assembly of Gold Nanoparticles
journal, June 2003

Colorimetric Biosensors Based on DNAzyme-Assembled Gold Nanoparticles
journal, July 2004

Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles
journal, January 2006

Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles
journal, January 2006

A catalytic beacon sensor for uranium with parts-per-trillion sensitivity and millionfold selectivity
journal, February 2007

Development of a Monoclonal Antibody against Ochratoxin A and Its Application in Enzyme-Linked Immunosorbent Assay and Gold Nanoparticle Immunochromatographic Strip
journal, September 2008

Functional Nucleic Acid Sensors
journal, May 2009

A Simple and Sensitive “Dipstick” Test in Serum Based on Lateral Flow Separation of Aptamer-Linked Nanostructures
journal, December 2006

Overview on self-monitoring of blood glucose
journal, April 2009

Nucleic acid aptamers and enzymes as sensors
journal, June 2006

Array Biosensor for Detection of Ochratoxin A in Cereals and Beverages
journal, January 2005

The developments of semisynthetic DNA–protein conjugates
journal, September 2002

Functional devices from DNA and proteins
journal, April 2007

Functional devices from DNA and proteins
journal, April 2007

Tools and Tactics for the Optical Detection of Mercuric Ion
journal, September 2008

Structure-Switching Signaling Aptamers
journal, April 2003

In Vitro Selection of Structure-Switching Signaling Aptamers
journal, February 2005

Aptamers with fluorescence-signaling properties
journal, September 2005

Highly Selective Oligonucleotide-Based Sensor for Mercury(II) in Aqueous Solutions
journal, August 2004

Interferon-γ assays in the immunodiagnosis of tuberculosis: a systematic review
journal, December 2004

Ochratoxin A: An overview on toxicity and carcinogenicity in animals and humans
journal, January 2007

Ochratoxin A: A review (Technical Report)
journal, January 1992

Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
journal, May 2008

Responsive magnetic resonance imaging contrast agents as chemical sensors for metals in biology and medicine
journal, January 2010

Selecting Nucleic Acids for Biosensor Applications
journal, June 2002

Studies on Identifying the Catalytic Role of Glu-204 in the Active Site of Yeast Invertase
journal, June 1996

Nucleic acid aptamers for biosensors and bio-analytical applications
journal, January 2009

Aptamer-based biosensors
journal, February 2008

Continuous, Real-Time Monitoring of Cocaine in Undiluted Blood Serum via a Microfluidic, Electrochemical Aptamer-Based Sensor
journal, April 2009

Magnetic labeling, detection, and system integration
journal, September 2008

Molecular beacons
journal, October 2004

Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase
journal, August 1990

Development of an Aptamer Beacon for Detection of Interferon-Gamma
journal, March 2010

Magnetic bead-based label-free
journal, October 2001

Metal Nanoparticle-Based Electrochemical Stripping Potentiometric Detection of DNA Hybridization
journal, November 2001

Carbon Nanotube/Teflon Composite Electrochemical Sensors and Biosensors
journal, March 2003

Electronic Aptamer-Based Sensors
journal, August 2007

Terminal Protection of Small-Molecule-Linked DNA for Sensitive Electrochemical Detection of Protein Binding via Selective Carbon Nanotube Assembly
journal, September 2009

Abasic Site-Containing DNAzyme and Aptamer for Label-Free Fluorescent Detection of Pb ²⁺ and Adenosine with High Sensitivity, Selectivity, and Tunable Dynamic Range
journal, October 2009

Using personal glucose meters and functional DNA sensors to quantify a variety of analytical targets
journal, July 2011

Using Commercially Available Personal Glucose Meters for Portable Quantification of DNA
journal, January 2012

Portable and Quantitative Detection of Protein Biomarkers and Small Molecular Toxins Using Antibodies and Ubiquitous Personal Glucose Meters
journal, April 2012

Electrochemical Detection of Parts-Per-Billion Lead via an Electrode-Bound DNAzyme Assembly
journal, January 2007

Ultrasensitive and Selective Colorimetric DNA Detection by Nicking Endonuclease Assisted Nanoparticle Amplification
journal, September 2009

One-Step, Room Temperature, Colorimetric Detection of Mercury (Hg ²⁺ ) Using DNA/Nanoparticle Conjugates
journal, March 2008

MRI Detection of Thrombin with Aptamer Functionalized Superparamagnetic Iron Oxide Nanoparticles
journal, February 2008

Comparison of Enzyme-Linked Immunosorbent Assays with Chemiluminescent and Colorimetric Detection for the Determination of Ochratoxin A in Food
journal, February 2011

Design of Gold Nanoparticle-Based Colorimetric Biosensing Assays
journal, October 2008

A Target-Responsive Electrochemical Aptamer Switch (TREAS) for Reagentless Detection of Nanomolar ATP
journal, February 2007

High Specificity, Electrochemical Sandwich Assays Based on Single Aptamer Sequences and Suitable for the Direct Detection of Small-Molecule Targets in Blood and Other Complex Matrices
journal, May 2009

Thermostable α-Amylase Conjugated Antibodies as Probes for Immunodetection in Elisa
journal, August 2002

Chemiluminescent enzyme immunoassay A review.
journal, January 1989