Global to push GA events into
skip to main content

Title: Microfluidic hubs, systems, and methods for interface fluidic modules

Embodiments of microfluidic hubs and systems are described that may be used to connect fluidic modules. A space between surfaces may be set by fixtures described herein. In some examples a fixture may set substrate-to-substrate spacing based on a distance between registration surfaces on which the respective substrates rest. Fluidic interfaces are described, including examples where fluid conduits (e.g. capillaries) extend into the fixture to the space between surfaces. Droplets of fluid may be introduced to and/or removed from microfluidic hubs described herein, and fluid actuators may be used to move droplets within the space between surfaces. Continuous flow modules may be integrated with the hubs in some examples.
; ; ; ; ;
Issue Date:
OSTI Identifier:
Sandia Corporation (Albuquerque, NM) SSO
Patent Number(s):
Application Number:
Contract Number:
Research Org:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

The Digital Revolution: A New Paradigm for Microfluidics
journal, February 2009
  • Abdelgawad, Mohamed; Wheeler, Aaron R.
  • Advanced Materials, Vol. 21, Issue 8, p. 920-925
  • DOI: 10.1002/adma.200802244

Biochip functionalization using electrowetting-on-dielectric digital microfluidics for surface plasmon resonance imaging detection of DNA hybridization
journal, March 2009
  • Malic, Lidija; Veres, Teodor; Tabrizian, Maryam
  • Biosensors and Bioelectronics, Vol. 24, Issue 7, p. 2218-2224
  • DOI: 10.1016/j.bios.2008.11.031

Droplet microfluidics
journal, January 2008
  • Teh, Shia-Yen; Lin, Robert; Hung, Lung-Hsin
  • Lab on a Chip, Vol. 8, Issue 2, p. 198-220
  • DOI: 10.1039/B715524G

Soft printing of droplets pre-metered by electrowetting
journal, September 2004
  • Yi, Ui-Chong; Kim, Chang-Jin “CJ”
  • Sensors and Actuators A: Physical, Vol. 114, Issue 2-3, p. 347-354
  • DOI: 10.1016/j.sna.2003.12.003

Synchronized Synthesis of Peptide-Based Macrocycles by Digital Microfluidics
journal, August 2010
  • Jebrail, Mais J.; Ng, Alphonsus H. C.; Rai, Vishal
  • Angewandte Chemie International Edition, Vol. 49, Issue 46, p. 8625-8629
  • DOI: 10.1002/anie.201001604

Automated Digital Microfluidic Sample Preparation for Next-Generation DNA Sequencing
journal, December 2011
  • Kim, Hanyoup; Bartsch, Michael S.; Renzi, Ronald F.
  • Journal of Laboratory Automation, Vol. 16, Issue 6, p. 405-414
  • DOI: 10.1016/j.jala.2011.07.001