Title: Microfluidic sieve valves

Abstract

Sieve valves for use in microfluidic device are provided. The valves are useful for impeding the flow of particles, such as chromatography beads or cells, in a microfluidic channel while allowing liquid solution to pass through the valve. The valves find particular use in making microfluidic chromatography modules.

Inventors:

Quake, Stephen R; Marcus, Joshua S; Hansen, Carl L

Issue Date:

2015-01-13

Research Org.:

California Institute of Technology (CalTech), Pasadena, CA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1167222

Patent Number(s):

8932461

Application Number:

13/171,329

Assignee:

California Institute of Technology (Pasadena, CA)

Patent Classifications (CPCs):

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

Show more

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY

B01J20/286 - Phases chemically bonded to a substrate, e.g. to silica or to polymers
B01J2220/54 - Sorbents specially adapted for analytical or investigative chromatography

B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

B01L3/502738 - {characterised by integrated valves
B01L3/502761 - {specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules

F - MECHANICAL ENGINEERING F16 - ENGINEERING ELEMENTS AND UNITS F16K - VALVES

F16K2099/0074 - {using photolithography, e.g. etching}
F16K2099/008 - {Multi-layer fabrications}
F16K2099/0084 - {Chemistry or biology, e.g. "lab-on-a-chip" technology}
F16K99/0001 - {Microvalves
F16K99/0026 - {Valves using channel deformation}
F16K99/0034 - {Operating means specially adapted for microvalves}
F16K99/0059 - {actuated by a pilot fluid}

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N30/6004 - {end pieces}
G01N30/603 - {retaining the stationary phase, e.g. Frits}
G01N30/6095 - {Micromachined or nanomachined, e.g. micro- or nanosize}

Show less

DOE Contract Number:  

FC02-02ER63420

Resource Type:

Patent

Resource Relation:

Patent File Date: 2011 Jun 28

Country of Publication:

United States

Language:

English

Subject:

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS