Method for non-contact particle manipulation and control of particle spacing along an axis

Goddard, Gregory R; Kaduchak, Gregory; Jett, James H; Graves, Steven W

Title: Method for non-contact particle manipulation and control of particle spacing along an axis

Abstract

Method and system for uniformly spacing particles in a flowing system comprising suspending particles in an elongated fluid filled cavity; exposing said cavity to an axial acoustic standing wave field, wherein said axial acoustic standing wave field drives said particles to nodal and anti-nodal positions along the center axis of said cavity to result in uniformly spaced particles; and focusing said particles to the center axis of said cavity.

Inventors:: Goddard, Gregory R; Kaduchak, Gregory; Jett, James H; Graves, Steven W

Issue Date:: 2015-01-13

Research Org.:: Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1167220

Patent Number(s):: 8932520

Application Number:: 13/570,605

Assignee:: Los Alamos National Security, LLC (Los Alamos, NM)

Patent Classifications (CPCs):: G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
G01N15/1484 - {microstructural devices}
G01N15/1404 - {Fluid conditioning in flow cytometers, e.g. flow cells
G01N2015/149 - {Sorting the particles}
G01N2015/142 - {Acoustic or ultrasonic focussing}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T137/206 - Flow affected by fluid contact, energy field or coanda effect [e.g., pure fluid device or system]

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DOE Contract Number:: AC52-06NA25396

Resource Type:: Patent

Resource Relation:: Patent File Date: 2012 Aug 09

Country of Publication:: United States

Language:: English

Subject:: 72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS

Citation Formats


                    Goddard, Gregory R, Kaduchak, Gregory, Jett, James H, and Graves, Steven W. Method for non-contact particle manipulation and control of particle spacing along an axis.  United States: N. p., 2015. 
        Web.

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                    Goddard, Gregory R, Kaduchak, Gregory, Jett, James H, & Graves, Steven W. Method for non-contact particle manipulation and control of particle spacing along an axis.  United States.

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                    Goddard, Gregory R, Kaduchak, Gregory, Jett, James H, and Graves, Steven W. Tue .  
        "Method for non-contact particle manipulation and control of particle spacing along an axis".  United States.  https://www.osti.gov/servlets/purl/1167220.

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@article{osti_1167220,

  title        = {Method for non-contact particle manipulation and control of particle spacing along an axis},

  author       = {Goddard, Gregory R and Kaduchak, Gregory and Jett, James H and Graves, Steven W},

  abstractNote = {Method and system for uniformly spacing particles in a flowing system comprising suspending particles in an elongated fluid filled cavity; exposing said cavity to an axial acoustic standing wave field, wherein said axial acoustic standing wave field drives said particles to nodal and anti-nodal positions along the center axis of said cavity to result in uniformly spaced particles; and focusing said particles to the center axis of said cavity.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2015},

  month        = {1}

}

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Applied Optics, Vol. 44, Issue 25, p. 5249-5256
https://doi.org/10.1364/AO.44.005249

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Title: Method for non-contact particle manipulation and control of particle spacing along an axis

Abstract

Citation Formats

Mathematical modeling of the movement of suspended particles subjected to acoustic and flow fields journal, June 2005

Use of acoustic radiation pressure to concentrate small particles in an air flow conference, January 2002

Ultrasonic separation in microfluidic capillaries conference, January 2003

Electroacoustic production of murine hybridomas journal, May 1990

Acoustic radiation potential on a sphere in plane, cylindrical, and spherical standing wave fields journal, March 1985

Formation and growth of ice particles in stationary ultrasonic fields journal, September 1998

Physical enviroment of 2-D animal cell aggregates formed in a short pathlength ultrasound standing wave trap journal, March 2005

Improved quartz crystal microbalance technique journal, August 1984

Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy journal, January 1990

Microchip-Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis journal, March 2006

Acoustic Radiation Pressure of Plane Compressional Waves journal, July 1953

Blue LED Excitable Temperature Sensors Based on a New Europium(III) Chelate journal, February 2008

Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: I. Concept and theoretical evaluation journal, July 1994

Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: II. Instrument design and experimental results journal, July 1994

Plasma preparation from whole blood using ultrasound journal, June 2000

Dynamics of suspended particles in a two-dimensional high-frequency sonic field journal, June 1995

Side drift of aerosols in two-dimensional resonant acoustic levitators journal, November 1997

Hydrodynamic orientation of sperm heads for flow cytometry journal, July 1978

A Novel Ultrasonic Resonance Field Device for the Retention of Animal Cells journal, July 1994

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. I. General formula journal, February 1997

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. II. Force on a rigid sphere journal, February 1997

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. III. Force on a liquid drop journal, February 1997

Acoustic Radiation Pressure on a Rigid Sphere in a Viscous Fluid journal, December 1994

Major signal increase in fluorescence microscopy through dark-state relaxation journal, December 2006

Experimental and model investigations of bleaching and saturation of fluorescence in flow cytometry journal, November 1997

Classification of Spectroscopically Encoded Resins by Raman Mapping and Infrared Hyperspectral Imaging journal, March 2006

Hydrodynamic orientation of cells. journal, July 1977

Selective Retention of Viable Cells in Ultrasonic Resonance Field Devices journal, February 1996

A new immobilisation method to arrange particles in a gel matrix by ultrasound standing waves journal, February 2005

Single particle high resolution spectral analysis flow cytometry journal, January 2006

Ultrasonic particle concentration in a line-driven cylindrical tube journal, June 2005

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer journal, January 2006

Precise Measurements Of Particle Entrainment In A Standing-Wave Acoustic Field Between 20 And 3500 Hz journal, December 2000

Upper sound pressure limits on particle concentration in fields of ultrasonic standing-wave at megahertz frequencies journal, January 1992

Single fiber model of particle retention in an acoustically driven porous mesh journal, March 2003

Single-collector experiments and modeling of acoustically aided mesh filtration journal, January 2005

Transport analysis and model for the performance of an ultrasonically enhanced filtration process journal, June 2005

Acoustically driven collection of suspended particles within porous media journal, March 1997

Fractionation of mixed particulate solids according to compressibility using ultrasonic standing wave fields journal, October 1995

Contactless micromanipulation of small particles by an ultrasound field excited by a vibrating body journal, May 2005

Manipulation of cells using an ultrasonic pressure field journal, June 2005

Positioning of small particles by an ultrasound field excited by surface waves journal, April 2004

Positioning, displacement, and localization of cells using ultrasonic forces journal, January 2005

An analytical system based on a compact flow cytometer for DNA fragment sizing and single-molecule detection journal, January 2004

Acoustic streaming generated by standing waves in two-dimensional channels of arbitrary width journal, January 2003

Linear and nonlinear frequency shifts in acoustical resonators with varying cross sections journal, July 2001

Zeptomole detection sensitivity of prostate-specific antigen in a rapid microtitre plate assay using time-resolved fluorescence journal, January 2000

A silicon microfluidic ultrasonic separator journal, October 2003

Near-Infrared Photo- and Electroluminescence of Alkoxy-Substituted Poly p-phenylene) and Nonconjugated Polymer/Lanthanide Tetraphenylporphyrin Blends journal, July 2004

Continuous cell washing and mixing driven by an ultrasound standing wave within a microfluidic channel journal, January 2004

Force field particle filter, combining ultrasound standing waves and laminar flow journal, May 2001

Microparticle manipulation in millimetre scale ultrasonic standing wave chambers journal, August 1998

Single half-wavelength ultrasonic particle filter: Predictions of the transfer matrix multilayer resonator model and experimental filtration results journal, March 2002

A laminar flow expansion chamber facilitating downstream manipulation of particles concentrated using an ultrasonic standing wave journal, July 1998

Ultrasonic deposition of cells on a surface journal, April 2004

Progress in Lanthanides as Luminescent Probes journal, July 2005

Standing‐wave acoustic trap for nonintrusive positioning of microparticles journal, October 1995

Migration of suspended particles in plane stationary ultrasonic field journal, January 1981

Modelling in the design of a flow-through ultrasonic separator journal, March 2000

Modelling of layered resonators for ultrasonic separation journal, May 2002

Operating Characteristics of Acoustically Driven Filtration Processes for Particulate Suspensions journal, January 2000

The selection of layer thicknesses to control acoustic radiation force profiles in layered resonators journal, January 2003

Fluorescence background discrimination by prebleaching. journal, January 1979

High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection journal, February 2006

The use of ultrasonic standing waves to enhance optical particle sizing equipment journal, March 2000

Mean force on a small sphere in a sound field in a viscous fluid journal, January 2000

The mean force acting on a small body in an axisymmetric sound field in a real medium journal, January 1987

Effect of Process Parameters on Ultrasonic Separation of Dispersed Particles in Liquid journal, May 1999

Development of a novel compact sonicator for cell disruption journal, February 2005

Ultrasound, a new separation technique to harvest microalgae journal, March 2003

Comparative analysis of whole blood lysis methods for flow cytometry journal, June 1997

Acoustic separation in a laminar flow conference, January 1994

Acoustic agglomeration of a glycol fog aerosol: Influence of particle concentration and intensity of the sound field at two frequencies journal, June 1995

Resolution of dimly fluorescent particles: A practical measure of fluorescence sensitivity journal, October 1998

Synthesis, Characterization, and Application of Eu(III), Tb(III), Sm(III), and Dy(III) Lanthanide Chelate Nanoparticle Labels journal, April 2005

Cellular platforms for HTS: three case studies journal, March 2002

Particle separation using ultrasound can be used with human shed mediastinal blood journal, January 2005

Mathematical modeling of the movement of suspended particles subjected to acoustic and flow fields
journal, June 2005

Use of acoustic radiation pressure to concentrate small particles in an air flow
conference, January 2002

Ultrasonic separation in microfluidic capillaries
conference, January 2003

Electroacoustic production of murine hybridomas
journal, May 1990

Acoustic radiation potential on a sphere in plane, cylindrical, and spherical standing wave fields
journal, March 1985

Formation and growth of ice particles in stationary ultrasonic fields
journal, September 1998

Physical enviroment of 2-D animal cell aggregates formed in a short pathlength ultrasound standing wave trap
journal, March 2005

Improved quartz crystal microbalance technique
journal, August 1984

Inorganic phosphors as new luminescent labels for immunocytochemistry and time-resolved microscopy
journal, January 1990

Microchip-Based Cell Lysis and DNA Extraction from Sperm Cells for Application to Forensic Analysis
journal, March 2006

Acoustic Radiation Pressure of Plane Compressional Waves
journal, July 1953

Blue LED Excitable Temperature Sensors Based on a New Europium(III) Chelate
journal, February 2008

Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: I. Concept and theoretical evaluation
journal, July 1994

Time-resolved flow cytometry for the measurement of lanthanide chelate fluorescence: II. Instrument design and experimental results
journal, July 1994

Plasma preparation from whole blood using ultrasound
journal, June 2000

Dynamics of suspended particles in a two-dimensional high-frequency sonic field
journal, June 1995

Side drift of aerosols in two-dimensional resonant acoustic levitators
journal, November 1997

Hydrodynamic orientation of sperm heads for flow cytometry
journal, July 1978

A Novel Ultrasonic Resonance Field Device for the Retention of Animal Cells
journal, July 1994

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. I. General formula
journal, February 1997

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. II. Force on a rigid sphere
journal, February 1997

Acoustic radiation force on a spherical particle in a viscous heat-conducting fluid. III. Force on a liquid drop
journal, February 1997

Acoustic Radiation Pressure on a Rigid Sphere in a Viscous Fluid
journal, December 1994

Major signal increase in fluorescence microscopy through dark-state relaxation
journal, December 2006

Experimental and model investigations of bleaching and saturation of fluorescence in flow cytometry
journal, November 1997

Classification of Spectroscopically Encoded Resins by Raman Mapping and Infrared Hyperspectral Imaging
journal, March 2006

Hydrodynamic orientation of cells.
journal, July 1977

Selective Retention of Viable Cells in Ultrasonic Resonance Field Devices
journal, February 1996

A new immobilisation method to arrange particles in a gel matrix by ultrasound standing waves
journal, February 2005

Single particle high resolution spectral analysis flow cytometry
journal, January 2006

Ultrasonic particle concentration in a line-driven cylindrical tube
journal, June 2005

Ultrasonic particle-concentration for sheathless focusing of particles for analysis in a flow cytometer
journal, January 2006

Precise Measurements Of Particle Entrainment In A Standing-Wave Acoustic Field Between 20 And 3500 Hz
journal, December 2000

Upper sound pressure limits on particle concentration in fields of ultrasonic standing-wave at megahertz frequencies
journal, January 1992

Single fiber model of particle retention in an acoustically driven porous mesh
journal, March 2003

Single-collector experiments and modeling of acoustically aided mesh filtration
journal, January 2005

Transport analysis and model for the performance of an ultrasonically enhanced filtration process
journal, June 2005

Acoustically driven collection of suspended particles within porous media
journal, March 1997

Fractionation of mixed particulate solids according to compressibility using ultrasonic standing wave fields
journal, October 1995

Contactless micromanipulation of small particles by an ultrasound field excited by a vibrating body
journal, May 2005

Manipulation of cells using an ultrasonic pressure field
journal, June 2005

Positioning of small particles by an ultrasound field excited by surface waves
journal, April 2004

Positioning, displacement, and localization of cells using ultrasonic forces
journal, January 2005

An analytical system based on a compact flow cytometer for DNA fragment sizing and single-molecule detection
journal, January 2004

Acoustic streaming generated by standing waves in two-dimensional channels of arbitrary width
journal, January 2003

Linear and nonlinear frequency shifts in acoustical resonators with varying cross sections
journal, July 2001

Zeptomole detection sensitivity of prostate-specific antigen in a rapid microtitre plate assay using time-resolved fluorescence
journal, January 2000

A silicon microfluidic ultrasonic separator
journal, October 2003

Near-Infrared Photo- and Electroluminescence of Alkoxy-Substituted Poly p-phenylene) and Nonconjugated Polymer/Lanthanide Tetraphenylporphyrin Blends
journal, July 2004

Continuous cell washing and mixing driven by an ultrasound standing wave within a microfluidic channel
journal, January 2004

Force field particle filter, combining ultrasound standing waves and laminar flow
journal, May 2001

Microparticle manipulation in millimetre scale ultrasonic standing wave chambers
journal, August 1998

Single half-wavelength ultrasonic particle filter: Predictions of the transfer matrix multilayer resonator model and experimental filtration results
journal, March 2002

A laminar flow expansion chamber facilitating downstream manipulation of particles concentrated using an ultrasonic standing wave
journal, July 1998

Ultrasonic deposition of cells on a surface
journal, April 2004

Progress in Lanthanides as Luminescent Probes
journal, July 2005

Standing‐wave acoustic trap for nonintrusive positioning of microparticles
journal, October 1995

Migration of suspended particles in plane stationary ultrasonic field
journal, January 1981

Modelling in the design of a flow-through ultrasonic separator
journal, March 2000

Modelling of layered resonators for ultrasonic separation
journal, May 2002

Operating Characteristics of Acoustically Driven Filtration Processes for Particulate Suspensions
journal, January 2000

The selection of layer thicknesses to control acoustic radiation force profiles in layered resonators
journal, January 2003

Fluorescence background discrimination by prebleaching.
journal, January 1979

High throughput particle analysis: Combining dielectrophoretic particle focussing with confocal optical detection
journal, February 2006

The use of ultrasonic standing waves to enhance optical particle sizing equipment
journal, March 2000

Mean force on a small sphere in a sound field in a viscous fluid
journal, January 2000

The mean force acting on a small body in an axisymmetric sound field in a real medium
journal, January 1987

Effect of Process Parameters on Ultrasonic Separation of Dispersed Particles in Liquid
journal, May 1999

Development of a novel compact sonicator for cell disruption
journal, February 2005

Ultrasound, a new separation technique to harvest microalgae
journal, March 2003

Comparative analysis of whole blood lysis methods for flow cytometry
journal, June 1997

Acoustic separation in a laminar flow
conference, January 1994

Acoustic agglomeration of a glycol fog aerosol: Influence of particle concentration and intensity of the sound field at two frequencies
journal, June 1995

Resolution of dimly fluorescent particles: A practical measure of fluorescence sensitivity
journal, October 1998

Synthesis, Characterization, and Application of Eu(III), Tb(III), Sm(III), and Dy(III) Lanthanide Chelate Nanoparticle Labels
journal, April 2005

Cellular platforms for HTS: three case studies
journal, March 2002

Particle separation using ultrasound can be used with human shed mediastinal blood
journal, January 2005

E₆ diffraction catastrophe of the primary rainbow of oblate water drops: observations with white-light and laser illumination
journal, January 1994

Hyperbolic umbilic and E₆ diffraction catastrophes associated with the secondary rainbow of oblate water drops: observations with laser illumination
journal, January 1994

Continuous particle size separation and size sorting using ultrasound in a microchannel
journal, January 2006