C-11 cyanide production system
Abstract
A method for providing .sup.11C-labeled cyanides from .sup.11C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O.sub.2 is provided, wherein .sup.11C labeled oxides are reduced with H.sub.2 in the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% .sup.11CH.sup.4 , the .sup.11CH.sub.4 is then combined with an excess of NH.sub.3 in a carrier/reaction stream flowing at an accelerated velocity and the combined .sup.11CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900 .degree. C., whereby a product stream comprising at least about 60%H.sup.11CN is provided in less than 10 minutes from retrieval of the .sup.11C labeled oxide.
- Inventors:
- Issue Date:
- Research Org.:
- Brookhaven National Laboratory (BNL), Upton, NY (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1167219
- Patent Number(s):
- 8932551
- Application Number:
- 13/584,033
- Assignee:
- Brookhaven Science Associates, LLC (Upton, NY)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01J - CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY
C - CHEMISTRY C01 - INORGANIC CHEMISTRY C01C - AMMONIA
- DOE Contract Number:
- AC02-98CH10886
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Aug 13
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
Citation Formats
Kim, Dohyun, Alexoff, David, Kim, Sung Won, Hooker, Jacob, and Ferrieri, Richard A. C-11 cyanide production system. United States: N. p., 2015.
Web.
Kim, Dohyun, Alexoff, David, Kim, Sung Won, Hooker, Jacob, & Ferrieri, Richard A. C-11 cyanide production system. United States.
Kim, Dohyun, Alexoff, David, Kim, Sung Won, Hooker, Jacob, and Ferrieri, Richard A. Tue .
"C-11 cyanide production system". United States. https://www.osti.gov/servlets/purl/1167219.
@article{osti_1167219,
title = {C-11 cyanide production system},
author = {Kim, Dohyun and Alexoff, David and Kim, Sung Won and Hooker, Jacob and Ferrieri, Richard A},
abstractNote = {A method for providing .sup.11C-labeled cyanides from .sup.11C labeled oxides in a target gas stream retrieved from an irradiated high pressure gaseous target containing O.sub.2 is provided, wherein .sup.11C labeled oxides are reduced with H.sub.2 in the presence of a nickel catalyst under a pressure and a temperature sufficient to form a product stream comprising at least about 95% .sup.11CH.sup.4 , the .sup.11CH.sub.4 is then combined with an excess of NH.sub.3 in a carrier/reaction stream flowing at an accelerated velocity and the combined .sup.11CH4 carrier/reaction stream is then contacted with a platinum (Pt) catalyst particulate supported on a substantially-chemically-nonreactive heat-stable support at a temperature of at least about 900 .degree. C., whereby a product stream comprising at least about 60%H.sup.11CN is provided in less than 10 minutes from retrieval of the .sup.11C labeled oxide.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {1}
}
Works referenced in this record:
Production of carrier-free H.sup.11 CN
patent, August 1978
- Christman, David R.; Finn, Ronald D.; Wolf, Alfred P.
- US Patent Document 4,106,982
Labelled compound
patent, December 1998
- Watanabe, Yasuyoshi; Omura, Hironori; Furuya, Yuji
- US Patent Document 5,847,193
Catalytic process
patent, January 1999
- Jackson, Samuel David; Hancock, Frederick Ernest; Crewdson, Bernard John
- US Patent Document 5,859,070
Fully-automated microfluidic system for the synthesis of radiolabeled biomarkers for positron emission tomography
patent, November 2010
- Van Dam, Robert Michael; Ball, Carroll Edward; Elizarov, Arkadij M.
- US Patent Document 7,829,032
Microfluidic Radiosynthesis System For Positron Emission Tomography Biomarkers
patent-application, February 2009
- Elizarov, Arkadij; Ball, Carroll; Zhang, Jianzhong
- US Patent Application 12/102822; 20090036668
The production of ultra high activity 11C-labeled hydrogen cyanide, carbon dioxide, carbon monoxide and methane via the 14N(p,α)11C reaction (XV)
journal, August 1975
- Christman, David R.; Finn, R. D.; Karlstrom, K. I.
- The International Journal of Applied Radiation and Isotopes, Vol. 26, Issue 8, p. 435-442