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Title: Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby

Abstract

Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.

Inventors:
;
Issue Date:
Research Org.:
The Regents of the University of California, Oakland, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1167214
Patent Number(s):
8,932,859
Application Number:
12/124,888
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
FG03-01ER63276
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 May 21
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Tsien, Roger Y, and Wang, Lei. Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby. United States: N. p., 2015. Web.
Tsien, Roger Y, & Wang, Lei. Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby. United States.
Tsien, Roger Y, and Wang, Lei. Tue . "Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby". United States. https://www.osti.gov/servlets/purl/1167214.
@article{osti_1167214,
title = {Methods for engineering polypeptide variants via somatic hypermutation and polypeptide made thereby},
author = {Tsien, Roger Y and Wang, Lei},
abstractNote = {Methods using somatic hypermutation (SHM) for producing polypeptide and nucleic acid variants, and nucleic acids encoding such polypeptide variants are disclosed. Such variants may have desired properties. Also disclosed are novel polypeptides, such as improved fluorescent proteins, produced by the novel methods, and nucleic acids, vectors, and host cells comprising such vectors.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2015},
month = {1}
}

Patent:

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