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Title: Pnp gene modification for improved xylose utilization in Zymomonas

The endogenous pnp gene encoding polynucleotide phosphorylase in the Zymomonas genome was identified as a target for modification to provide improved xylose utilizing cells for ethanol production. The cells are in addition genetically modified to have increased expression of ribose-5-phosphate isomerase (RPI) activity, as compared to cells without this genetic modification, and are not limited in xylose isomerase activity in the absence of the pnp modification.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1165440
Assignee:
E I Du Pont de Nemours and Company (Wilmington, DE) GFO
Patent Number(s):
8,911,983
Application Number:
13/711,646
Contract Number:
FC36-07GO17056
Resource Relation:
Patent File Date: 2012 Dec 12
Research Org:
E I Du Pont de Nemours and Company, Wilmington, DE (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES; 09 BIOMASS FUELS

Other works cited in this record:

Metabolic engineering of a xylose-isomerase-expressing strain for rapid anaerobic xylose fermentation
journal, February 2005

Global analysis of Escherichia coli RNA degradosome function using DNA microarrays
journal, February 2004
  • Bernstein, J. A.; Lin, P.-H.; Cohen, S. N.
  • Proceedings of the National Academy of Sciences, Vol. 101, Issue 9, p. 2758-2763
  • DOI: 10.1073/pnas.0308747101

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