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Title: Engineering of thermotolerant Bacillus coagulans for production of D(-)-lactic acid

Genetically modified microorganisms having the ability to produce D(-)-lactic acid at temperatures between C. and C. are provided. In various embodiments, the microorganisms may have the chromosomal lactate dehydrogenase (ldh) gene and/or the chromosomal acetolactate synthase (alsS) gene inactivated. Exemplary microorganisms for use in the disclosed methods are Bacillus spp., such as Bacillus coagulans.
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University of Florida Research Foundation, Inc. (Gainesville, FL) GFO
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Resource Relation:
Patent File Date: 2011 Nov 22
Research Org:
University of Florida Research Foundation, Inc., Gainesville, FL (United States)
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Country of Publication:
United States

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