Title: 3D and 4D magnetic susceptibility tomography based on complex MR images

Abstract

Magnetic susceptibility is the physical property for T2*-weighted magnetic resonance imaging (T2*MRI). The invention relates to methods for reconstructing an internal distribution (3D map) of magnetic susceptibility values, .chi. (x,y,z), of an object, from 3D T2*MRI phase images, by using Computed Inverse Magnetic Resonance Imaging (CIMRI) tomography. The CIMRI technique solves the inverse problem of the 3D convolution by executing a 3D Total Variation (TV) regularized iterative convolution scheme, using a split Bregman iteration algorithm. The reconstruction of .chi. (x,y,z) can be designed for low-pass, band-pass, and high-pass features by using a convolution kernel that is modified from the standard dipole kernel. Multiple reconstructions can be implemented in parallel, and averaging the reconstructions can suppress noise. 4D dynamic magnetic susceptibility tomography can be implemented by reconstructing a 3D susceptibility volume from a 3D phase volume by performing 3D CIMRI magnetic susceptibility tomography at each snapshot time.

Inventors:

Chen, Zikuan; Calhoun, Vince D.

Issue Date:

2014-11-11

Research Org.:

STC.UNM, Albuquerque, NM (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1163670

Patent Number(s):

8886283

Application Number:

13/526,210

Assignee:

STC.UNM (Albuquerque, NM)

Patent Classifications (CPCs):

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B5/4064 - {Evaluating the brain
A61B5/7257 - {using Fourier transforms}

G - PHYSICS G16 - INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS G16H - HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA

G16H30/40 - for processing medical images, e.g. editing

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61B - DIAGNOSIS

A61B2576/026 - for the brain
A61B5/7246 - {using correlation, e.g. template matching or determination of similarity}
A61B5/055 - involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging

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DOE Contract Number:  

FG02-08ER64581

Resource Type:

Patent

Resource Relation:

Patent File Date: 2012 Jun 18

Country of Publication:

United States

Language:

English

Subject:

47 OTHER INSTRUMENTATION