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Title: Amphiphiles for protein solubilization and stabilization

The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1163212
Assignee:
Wisconsin Aumni Research Foundation (Madison, WI) ANL
Patent Number(s):
8,877,906
Application Number:
13/608,385
Contract Number:
W-31-109-ENG38
Resource Relation:
Patent File Date: 2012 Sep 10
Research Org:
Wisconsin Aumni Research Foundation, Madison, WI (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Other works cited in this record:

Synthesis of some aglycon analogs of globotriosylceramide
journal, December 1999

Synthesis and mesogenic properties of a Y-shaped glyco-glycero-lipid
journal, August 2004

Glycotripod Amphiphiles for Solubilization and Stabilization of a Membrane‐Protein Superassembly: Importance of Branching in the Hydrophilic Portion
journal, July 2008
  • Chae, Pil S.; Wander, Marc J.; Bowling, Aaron P.
  • ChemBioChem, Vol. 9, Issue 11, p. 1706-1709
  • DOI: 10.1002/cbic.200800169

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