Amphiphiles for protein solubilization and stabilization
Abstract
The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.
- Inventors:
- Issue Date:
- Research Org.:
- Wisconsin Aumni Research Foundation, Madison, WI (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1163212
- Patent Number(s):
- 8877906
- Application Number:
- 13/608,385
- Assignee:
- Wisconsin Aumni Research Foundation (Madison, WI)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07H - SUGARS
- DOE Contract Number:
- W-31-109-ENG38
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Sep 10
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, and Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States: N. p., 2014.
Web.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, & Wander, Marc J. Amphiphiles for protein solubilization and stabilization. United States.
Gellman, Samuel Helmer, Chae, Pil Seok, Laible, Phillip D, and Wander, Marc J. Tue .
"Amphiphiles for protein solubilization and stabilization". United States. https://www.osti.gov/servlets/purl/1163212.
@article{osti_1163212,
title = {Amphiphiles for protein solubilization and stabilization},
author = {Gellman, Samuel Helmer and Chae, Pil Seok and Laible, Phillip D and Wander, Marc J},
abstractNote = {The invention provides amphiphiles for manipulating membrane proteins. The amphiphiles can feature carbohydrate-derived hydrophilic groups and branchpoints in the hydrophilic moiety and/or in a lipophilic moiety. Such amphiphiles are useful as detergents for solubilization and stabilization of membrane proteins, including photosynthetic protein superassemblies obtained from bacterial membranes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {11}
}
Works referenced in this record:
Amphiphilic agents for membrane protein solubilization
patent, January 2001
- McQuade, D. Tyler; Gellman, Samuel H.
- US Patent Document 6,172,262
Synthetic Amphiphiles for Membrane Protein Manipulation
patent-application, December 2010
- Gellman, Samuel Helmer; Chae, Pil Seok; Kobilka, Brian
- US Patent Application 12/731000; 20100311956
A Straightforward Synthesis of 1-Adamantylmethyl Glycosides, and Their Binding to Cyclodextrins
journal, September 2004
- Charbonnier, Florence; Penadés, Soledad
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Synthesis of some aglycon analogs of globotriosylceramide
journal, December 1999
- Hansen, Henrik C.; Magnusson, Göran
- Carbohydrate Research, Vol. 322, Issue 3-4, p. 181-189
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journal, August 2004
- Milkereit, G.; Garamus, V. M.; Veermans, K.
- Chemistry and Physics of Lipids, Vol. 131, Issue 1, p. 51-61
Glycotripod Amphiphiles for Solubilization and Stabilization of a Membrane‐Protein Superassembly: Importance of Branching in the Hydrophilic Portion
journal, July 2008
- Chae, Pil S.; Wander, Marc J.; Bowling, Aaron P.
- ChemBioChem, Vol. 9, Issue 11, p. 1706-1709
Works referencing / citing this record:
Amphiphiles for protein solubilization and stabilization
patent, November 2014
- Gellman, Samuel H.; Chae, Pil Seok; Laible, Phillip D.
- US Patent Document 8,877,906