Methods for separating medical isotopes using ionic liquids
Abstract
A method for extracting a radioisotope from an aqueous solution, the method comprising: a) intimately mixing a non-chelating ionic liquid with the aqueous solution to transfer at least a portion of said radioisotope to said non-chelating ionic liquid; and b) separating the non-chelating ionic liquid from the aqueous solution. In preferred embodiments, the method achieves an extraction efficiency of at least 80%, or a separation factor of at least 1.times.10.sup.4 when more than one radioisotope is included in the aqueous solution. In particular embodiments, the method is applied to the separation of medical isotopes pairs, such as Th from Ac (Th-229/Ac-225, Ac-227/Th-227), or Ra from Ac (Ac-225 and Ra-225, Ac-227 and Ra-223), or Ra from Th (Th-227 and Ra-223, Th-229 and Ra-225).
- Inventors:
- Issue Date:
- Research Org.:
- Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1160264
- Patent Number(s):
- 8865094
- Application Number:
- 13/614,757
- Assignee:
- UT-Battelle, LLC (Oak Ridge, TN)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C22 - METALLURGY C22B - PRODUCTION AND REFINING OF METALS
G - PHYSICS G21 - NUCLEAR PHYSICS G21F - PROTECTION AGAINST X-RADIATION, GAMMA RADIATION, CORPUSCULAR RADIATION OR PARTICLE BOMBARDMENT
- DOE Contract Number:
- AC05-00OR22725
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Sep 13
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY
Citation Formats
Luo, Huimin, Boll, Rose Ann, Bell, Jason Richard, and Dai, Sheng. Methods for separating medical isotopes using ionic liquids. United States: N. p., 2014.
Web.
Luo, Huimin, Boll, Rose Ann, Bell, Jason Richard, & Dai, Sheng. Methods for separating medical isotopes using ionic liquids. United States.
Luo, Huimin, Boll, Rose Ann, Bell, Jason Richard, and Dai, Sheng. Tue .
"Methods for separating medical isotopes using ionic liquids". United States. https://www.osti.gov/servlets/purl/1160264.
@article{osti_1160264,
title = {Methods for separating medical isotopes using ionic liquids},
author = {Luo, Huimin and Boll, Rose Ann and Bell, Jason Richard and Dai, Sheng},
abstractNote = {A method for extracting a radioisotope from an aqueous solution, the method comprising: a) intimately mixing a non-chelating ionic liquid with the aqueous solution to transfer at least a portion of said radioisotope to said non-chelating ionic liquid; and b) separating the non-chelating ionic liquid from the aqueous solution. In preferred embodiments, the method achieves an extraction efficiency of at least 80%, or a separation factor of at least 1.times.10.sup.4 when more than one radioisotope is included in the aqueous solution. In particular embodiments, the method is applied to the separation of medical isotopes pairs, such as Th from Ac (Th-229/Ac-225, Ac-227/Th-227), or Ra from Ac (Ac-225 and Ra-225, Ac-227 and Ra-223), or Ra from Th (Th-227 and Ra-223, Th-229 and Ra-225).},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {10}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Ionic liquid type crown ether derivatives, method for preparing the same and method for isolating metal ions using the same
patent, December 2010
- Park, Sang Hyun; Jang, Seung-Ho; Gwon, Hui Jeong
- US Patent Document 7,851,496
Cyclic guanidine ionic liquid
patent, March 2012
- Kawada, Atsushi; Tashiro, Aya; Kumagai, Toshihiro
- US Patent Document 8,129,543
Microparticles prepared using an ionic liquid
patent-application, July 2006
- Ausborn, Michael; Kissel, Thomas; Kusters, Ernst
- US Patent Application 10/537038; 20060147532
Method of Separating Aromatic Compound from Mixture Containing Aromatic Compound and Aliphatic Compound
patent-application, October 2010
- Lim, Myong Hoon; Lim, Young Mi; Kim, Yong Soo
- US Patent Application 12/755951; 20100261945
Methods of Preparing Ionic Liquids
patent-application, March 2011
- Maase, Matthias; Massonne, Klemens; Szarvas, Laszlo
- US Patent Application 12/951726; 20110065926
Lanthanides and Actinides in Ionic Liquids
journal, June 2007
- Binnemans, Koen
- Chemical Reviews, Vol. 107, Issue 6
Optimizations of Radiolabeling of Immunoproteins with 213Bi
journal, January 1997
- Boll, Rose A.; Mirzadeh, Saed; Kennel, Stephen J.
- Radiochimica Acta, Vol. 79, Issue 2
Solvent extraction of strontium nitrate by a crown ether using room-temperature ionic liquids †
journal, January 1999
- Dai, Sheng; Ju, Y. H.; Barnes, C. E.
- Journal of the Chemical Society, Dalton Transactions, Issue 8
Ion-exchange as a mode of cation transfer into room-temperature ionic liquids containing crown ethers: implications for the ‘greenness’ of ionic liquids as diluents in liquid–liquid extraction
journal, October 2001
- Dietz, Mark L.; Dzielawa, Julie A.
- Chemical Communications, Issue 20, p. 2124-2125
Protic Ionic Liquids: Properties and Applications
journal, January 2008
- Greaves, Tamar L.; Drummond, Calum J.
- Chemical Reviews, Vol. 108, Issue 1, p. 206-237
Bicyclic imidazolium-based ionic liquids: synthesis and characterization
journal, February 2007
- Kan, Huang-Chuan; Tseng, Ming-Chung; Chu, Yen-Ho
- Tetrahedron, Vol. 63, Issue 7, p. 1644-1653
Solvent Extraction of Sr 2+ and Cs + Based on Room-Temperature Ionic Liquids Containing Monoaza-Substituted Crown Ethers
journal, May 2004
- Luo, Huimin; Dai, Sheng; Bonnesen, Peter V.
- Analytical Chemistry, Vol. 76, Issue 10
A Striking Effect of Ionic‐Liquid Anions in the Extraction of Sr 2+ and Cs + by Dicyclohexano‐18‐Crown‐6
journal, March 2006
- Luo, H.; Dai, S.; Bonnesen, P. V.
- Solvent Extraction and Ion Exchange, Vol. 24, Issue 1
An 225Ac/213Bi generator system for therapeutic clinical applications: construction and operation
journal, May 1999
- McDevitt, Michael R.; Finn, Ronald D.; Sgouros, George
- Applied Radiation and Isotopes, Vol. 50, Issue 5, p. 895-904
Feasibility of Ionic Liquids as Alternative Separation Media for Industrial Solvent Extraction Processes
journal, June 2005
- Nakashima, Kazunori; Kubota, Fukiko; Maruyama, Tatsuo
- Industrial & Engineering Chemistry Research, Vol. 44, Issue 12
Task-specific ionic liquids for the extraction of metal ions from aqueous solutions
journal, January 2001
- Visser, Ann E.; Swatloski, Richard P.; Reichert, W. Matthew
- Chemical Communications, Issue 1
An Improved Generator for the Production of 213Bi from 225Ac
journal, January 1997
- Wu, Chuanchu; Brechbiel, Martin W.; Gansow, Otto A.
- Radiochimica Acta, Vol. 79, Issue 2
Efficient removal of caesium ions from aqueous solution using a calix crown ether in ionic liquids: mechanism and radiation effect
journal, January 2010
- Xu, Chao; Yuan, Liyong; Shen, Xinghai
- Dalton Transactions, Vol. 39, Issue 16