Global to push GA events into
skip to main content

Title: Microorganisms having enhanced resistance to acetate and methods of use

The present invention provides isolated or genetically modified strains of microorganisms that display enhanced resistance to acetate as a result of increased expression of a sodium proton antiporter. The present invention also provides methods for producing such microbial strains, as well as related promoter sequences and expression vectors. Further, the present invention provides methods of producing alcohol from biomass materials by using microorganisms with enhanced resistance to acetate.
Issue Date:
OSTI Identifier:
UT-Batelle, LLC (Oakridge, TN) ORNL
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2012 Nov 29
Research Org:
Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Increased tolerance and conversion of inhibitors in lignocellulosic hydrolysates by Saccharomyces cerevisiae
journal, January 2007
  • Almeida, Joao; Modig, Tobias; Petersson, Anneli
  • Journal of Chemical Technology & Biotechnology, Vol. 82, Issue 4, p. 340-349
  • DOI: 10.1002/jctb.1676

Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production, while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus SKU1108
journal, January 2003
  • Chinnawirotpisan, Piyawan; Theeragool, Gunjana; Limtong, Savitree
  • Journal of Bioscience and Bioengineering, Vol. 96, Issue 6, p. 564-571
  • DOI: 10.1016/S1389-1723(04)70150-4

Bacteria engineered for fuel ethanol production: current status
journal, December 2003
  • Dien, B. S.; Cotta, M. A.; Jeffries, T. W.
  • Applied Microbiology and Biotechnology, Vol. 63, Issue 3, p. 258-266
  • DOI: 10.1007/s00253-003-1444-y

The aarC gene responsible for acetic acid assimilation confers acetic acid resistance on acetobacter aceti
journal, January 1993
  • Fukaya, Masahiro; Takemura, Hiroshi; Tayama, Kenji
  • Journal of Fermentation and Bioengineering, Vol. 76, Issue 4, p. 270-275
  • DOI: 10.1016/0922-338X(93)90192-B

Characterization of the NHA1 gene encoding a Na+/H+-antiporter of the yeast Saccharomyces cerevisiae
journal, May 1996

Mapping Pathways and Phenotypes by Systematic Gene Overexpression
journal, February 2006

Over-expression of the bacterial nhaA gene in rice enhances salt and drought tolerance
journal, February 2005