Biocompatible implants and methods of making and attaching the same

Rowley, Adrian P; Laude, Lucien D; Humayun, Mark S; Weiland, James D; Lotfi, Atoosa; Markland, Francis S

Title: Biocompatible implants and methods of making and attaching the same

Abstract

The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.

Inventors:: Rowley, Adrian P; Laude, Lucien D; Humayun, Mark S; Weiland, James D; Lotfi, Atoosa; Markland, Jr., Francis S

Issue Date:: 2014-10-07

Research Org.:: Doheny Eye Institute, Los Angeles, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1160226

Patent Number(s):: 8852290

Application Number:: 12/041,651

Assignee:: Doheny Eye Institute (Los Angeles, CA)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61F - FILTERS IMPLANTABLE INTO BLOOD VESSELS
A61F2/148 - {Implantation instruments specially adapted therefor}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
A61L2400/18 - Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
A61L27/34 - Macromolecular materials
A61L27/50 - Materials characterised by their function or physical properties {, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials}

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61N - ELECTROTHERAPY
A61N1/0543 - {Retinal electrodes}
A61N1/36046 - {of the eye}

C - CHEMISTRY C08 - ORGANIC MACROMOLECULAR COMPOUNDS C08L - COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
C08L89/00 - Compositions of proteins

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Resource Type:: Patent

Resource Relation:: Patent File Date: 2008 Mar 03

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Rowley, Adrian P, Laude, Lucien D, Humayun, Mark S, Weiland, James D, Lotfi, Atoosa, and Markland, Jr., Francis S. Biocompatible implants and methods of making and attaching the same.  United States: N. p., 2014. 
        Web.

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                    Rowley, Adrian P, Laude, Lucien D, Humayun, Mark S, Weiland, James D, Lotfi, Atoosa, & Markland, Jr., Francis S. Biocompatible implants and methods of making and attaching the same.  United States.

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                    Rowley, Adrian P, Laude, Lucien D, Humayun, Mark S, Weiland, James D, Lotfi, Atoosa, and Markland, Jr., Francis S. Tue .  
        "Biocompatible implants and methods of making and attaching the same".  United States.  https://www.osti.gov/servlets/purl/1160226.

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@article{osti_1160226,

  title        = {Biocompatible implants and methods of making and attaching the same},

  author       = {Rowley, Adrian P and Laude, Lucien D and Humayun, Mark S and Weiland, James D and Lotfi, Atoosa and Markland, Jr., Francis S},

  abstractNote = {The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {10}

}

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Title: Biocompatible implants and methods of making and attaching the same

Abstract

Citation Formats

Laser generated high electron density source patent, August 1982

Human collagen processing and autoimplant use patent, November 1990

Surface-active macromonomers patent, January 1993

Removal of surface contaminants by irradiation from a high energy source patent, July 1996

Corneal onlays patent, February 1998

Peptide-coated implants and methods for producing same patent, August 2001

Chronically implantable retinal prosthesis patent, November 2001

Contortrostain (CN) and methods for its use in preventing metastasis and other conditions patent, March 2004

Optical information storage medium and method for manufacturing the same patent, January 2007

Single-piece accomodating intraocular lens system patent-application, April 2003

Transistor manufacturing method, electrooptical apparatus and electronic apparatus patent-application, December 2004

Method for manufacturing semiconductor device patent-application, September 2005

Method of pulsed laser assisted surface modification patent-application, March 2006

Nanorods and other materials from condensed phase conversion and growth instead of from vapor patent-application, May 2006

Medical device applications of nanostructured surfaces patent-application, September 2006

Controlled vapor deposition of biocompatible coatings for medical devices patent-application, November 2006

Polypeptides and antibodies patent-application, August 2007

Laser ablation processes investigated using inductively coupled plasma–atomic emission spectroscopy (ICP–AES) journal, May 1998

Laser generated high electron density source
patent, August 1982

Human collagen processing and autoimplant use
patent, November 1990

Surface-active macromonomers
patent, January 1993

Removal of surface contaminants by irradiation from a high energy source
patent, July 1996

Corneal onlays
patent, February 1998

Peptide-coated implants and methods for producing same
patent, August 2001

Chronically implantable retinal prosthesis
patent, November 2001

Contortrostain (CN) and methods for its use in preventing metastasis and other conditions
patent, March 2004

Optical information storage medium and method for manufacturing the same
patent, January 2007

Single-piece accomodating intraocular lens system
patent-application, April 2003

Transistor manufacturing method, electrooptical apparatus and electronic apparatus
patent-application, December 2004

Method for manufacturing semiconductor device
patent-application, September 2005

Method of pulsed laser assisted surface modification
patent-application, March 2006

Nanorods and other materials from condensed phase conversion and growth instead of from vapor
patent-application, May 2006

Medical device applications of nanostructured surfaces
patent-application, September 2006

Controlled vapor deposition of biocompatible coatings for medical devices
patent-application, November 2006

Polypeptides and antibodies
patent-application, August 2007

Laser ablation processes investigated using inductively coupled plasma–atomic emission spectroscopy (ICP–AES)
journal, May 1998