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Title: Biocompatible implants and methods of making and attaching the same

Abstract

The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Doheny Eye Institute, Los Angeles, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1160226
Patent Number(s):
8,852,290
Application Number:
12/041,651
Assignee:
Doheny Eye Institute (Los Angeles, CA) OSTI
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Mar 03
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Citation Formats

Rowley, Adrian P, Laude, Lucien D, Humayun, Mark S, Weiland, James D, Lotfi, Atoosa, and Markland, Jr., Francis S. Biocompatible implants and methods of making and attaching the same. United States: N. p., 2014. Web.
Rowley, Adrian P, Laude, Lucien D, Humayun, Mark S, Weiland, James D, Lotfi, Atoosa, & Markland, Jr., Francis S. Biocompatible implants and methods of making and attaching the same. United States.
Rowley, Adrian P, Laude, Lucien D, Humayun, Mark S, Weiland, James D, Lotfi, Atoosa, and Markland, Jr., Francis S. Tue . "Biocompatible implants and methods of making and attaching the same". United States. https://www.osti.gov/servlets/purl/1160226.
@article{osti_1160226,
title = {Biocompatible implants and methods of making and attaching the same},
author = {Rowley, Adrian P and Laude, Lucien D and Humayun, Mark S and Weiland, James D and Lotfi, Atoosa and Markland, Jr., Francis S},
abstractNote = {The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attaching such implants are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {10}
}

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Works referenced in this record:

Laser ablation processes investigated using inductively coupled plasma–atomic emission spectroscopy (ICP–AES)
journal, May 1998