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Title: Producing a trimethylpentanoic acid using hybrid polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host cell of the present invention, and culturing said host cell in a suitable culture medium such that the trimethylpentanoic acid is produced, optionally isolating the trimethylpentanoic acid, and optionally, reducing the isolated trimethylpentanoic acid into a trimethylpentanol or an iso-octane.

Inventors:
; ;
Issue Date:
Research Org.:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1160210
Patent Number(s):
8852902
Application Number:
13/302,966
Assignee:
The Regents of the University of California (Oakland, CA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
DOE Contract Number:  
AC02-05CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Nov 22
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats

Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Producing a trimethylpentanoic acid using hybrid polyketide synthases. United States: N. p., 2014. Web.
Katz, Leonard, Fortman, Jeffrey L, & Keasling, Jay D. Producing a trimethylpentanoic acid using hybrid polyketide synthases. United States.
Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Tue . "Producing a trimethylpentanoic acid using hybrid polyketide synthases". United States. https://www.osti.gov/servlets/purl/1160210.
@article{osti_1160210,
title = {Producing a trimethylpentanoic acid using hybrid polyketide synthases},
author = {Katz, Leonard and Fortman, Jeffrey L and Keasling, Jay D},
abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host cell of the present invention, and culturing said host cell in a suitable culture medium such that the trimethylpentanoic acid is produced, optionally isolating the trimethylpentanoic acid, and optionally, reducing the isolated trimethylpentanoic acid into a trimethylpentanol or an iso-octane.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {10}
}

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Works referenced in this record:

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A new synthesis of (±)-phoracantholide, (±)-dihydrorecifeiolide, and (±)-muscone via α-nitro ketones
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