Producing a trimethylpentanoic acid using hybrid polyketide synthases

Katz, Leonard; Fortman, Jeffrey L; Keasling, Jay D

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Title: Producing a trimethylpentanoic acid using hybrid polyketide synthases

Abstract

The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host cell of the present invention, and culturing said host cell in a suitable culture medium such that the trimethylpentanoic acid is produced, optionally isolating the trimethylpentanoic acid, and optionally, reducing the isolated trimethylpentanoic acid into a trimethylpentanol or an iso-octane.

Inventors:: Katz, Leonard; Fortman, Jeffrey L; Keasling, Jay D

Issue Date:: Tue Oct 07 00:00:00 EDT 2014

Research Org.:: Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1160210

Patent Number(s):: 8852902

Application Number:: 13/302,966

Assignee:: The Regents of the University of California (Oakland, CA)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

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C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C12N15/52 - Genes encoding for enzymes or proenzymes

C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P7/40 - containing a carboxyl group {including Peroxycarboxylic acids

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DOE Contract Number:: AC02-05CH11231

Resource Type:: Patent

Resource Relation:: Patent File Date: 2011 Nov 22

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Citation Formats


                    Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Producing a trimethylpentanoic acid using hybrid polyketide synthases.  United States: N. p., 2014. 
        Web.

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                    Katz, Leonard, Fortman, Jeffrey L, & Keasling, Jay D. Producing a trimethylpentanoic acid using hybrid polyketide synthases.  United States.

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                    Katz, Leonard, Fortman, Jeffrey L, and Keasling, Jay D. Tue .  
        "Producing a trimethylpentanoic acid using hybrid polyketide synthases".  United States.  https://www.osti.gov/servlets/purl/1160210.

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@article{osti_1160210,

  title        = {Producing a trimethylpentanoic acid using hybrid polyketide synthases},

  author       = {Katz, Leonard and Fortman, Jeffrey L and Keasling, Jay D},

  abstractNote = {The present invention provides for a polyketide synthase (PKS) capable of synthesizing trimethylpentanoic acid. The present invention also provides for a host cell comprising the PKS and when cultured produces the trimethylpentanoic acid. The present invention also provides for a method of producing the trimethylpentanoic acid, comprising: providing a host cell of the present invention, and culturing said host cell in a suitable culture medium such that the trimethylpentanoic acid is produced, optionally isolating the trimethylpentanoic acid, and optionally, reducing the isolated trimethylpentanoic acid into a trimethylpentanol or an iso-octane.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Oct 07 00:00:00 EDT 2014},

  month        = {Tue Oct 07 00:00:00 EDT 2014}

}

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Similar Records

Title: Producing a trimethylpentanoic acid using hybrid polyketide synthases

Abstract

Citation Formats

Food additive sanitizing compositions patent, August 1993

Recombinant production of novel polyketides patent, September 1997

Recombinant combinatorial genetic library for the production of novel polyketides patent, January 1998

Recombinant production of novel polyketides patent, November 1998

Recombinant production of novel polyketides patent, December 1998

Production of polyketides in plants patent, July 2001

Recombinant methods and materials for producing epothilones C and D patent, October 2001

Anticancer agents, perfumes or foods and drinks patent, October 2003

Fragrance precursors patent, September 2005

Polyketides and their synthesis patent, April 2007

Producing biofuels using polyketide synthases patent, April 2013

Biosynthesis of polyketide synthase substrates patent-application, April 2002

Biosynthesis of polyketide synthase substrates patent-application, December 2002

Genetic Contributions to Understanding Polyketide Synthases journal, November 1997

A new synthesis of (±)-phoracantholide, (±)-dihydrorecifeiolide, and (±)-muscone via α-nitro ketones journal, July 1995

A chain initiation factor common to both modular and aromatic polyketide synthases journal, September 1999

The synthesis of 14-membered macrocyclic ethers journal, November 1999

Synthesis of C5-dicarboxylic acids from C2-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway journal, June 2007

New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones journal, July 2003

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units journal, February 2001

Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase journal, July 1997

Switching from S - to R- Selectivity in the Candida antarctica Lipase B-Catalyzed Ring-Opening of ω-Methylated Lactones: Tuning Polymerizations by Ring Size journal, June 2007

Food additive sanitizing compositions
patent, August 1993

Recombinant production of novel polyketides
patent, September 1997

Recombinant combinatorial genetic library for the production of novel polyketides
patent, January 1998

Recombinant production of novel polyketides
patent, November 1998

Recombinant production of novel polyketides
patent, December 1998

Production of polyketides in plants
patent, July 2001

Recombinant methods and materials for producing epothilones C and D
patent, October 2001

Anticancer agents, perfumes or foods and drinks
patent, October 2003

Fragrance precursors
patent, September 2005

Polyketides and their synthesis
patent, April 2007

Producing biofuels using polyketide synthases
patent, April 2013

Biosynthesis of polyketide synthase substrates
patent-application, April 2002

Biosynthesis of polyketide synthase substrates
patent-application, December 2002

Genetic Contributions to Understanding Polyketide Synthases
journal, November 1997

A new synthesis of (±)-phoracantholide, (±)-dihydrorecifeiolide, and (±)-muscone via α-nitro ketones
journal, July 1995

A chain initiation factor common to both modular and aromatic polyketide synthases
journal, September 1999

The synthesis of 14-membered macrocyclic ethers
journal, November 1999

Synthesis of C₅-dicarboxylic acids from C₂-units involving crotonyl-CoA carboxylase/reductase: The ethylmalonyl-CoA pathway
journal, June 2007

New silicon-mediated ring expansion of n-sized conjugated cycloalkenones into homoallylic n+3 lactones
journal, July 2003

Role of type II thioesterases: evidence for removal of short acyl chains produced by aberrant decarboxylation of chain extender units
journal, February 2001

Precursor-Directed Biosynthesis of Erythromycin Analogs by an Engineered Polyketide Synthase
journal, July 1997

Switching from S - to R- Selectivity in the Candida antarctica Lipase B-Catalyzed Ring-Opening of ω-Methylated Lactones: Tuning Polymerizations by Ring Size
journal, June 2007