Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease
Abstract
Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
- Inventors:
- Issue Date:
- Research Org.:
- Univ. of California, Oakland, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1160128
- Patent Number(s):
- 8845999
- Application Number:
- 11/920,904
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- DOE Contract Number:
- FC03-02ER63420
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2006 May 23
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Wright, Ernest M, Barrio, Jorge R, Hirayama, Bruce A, and Kepe, Vladimir. Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease. United States: N. p., 2014.
Web.
Wright, Ernest M, Barrio, Jorge R, Hirayama, Bruce A, & Kepe, Vladimir. Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease. United States.
Wright, Ernest M, Barrio, Jorge R, Hirayama, Bruce A, and Kepe, Vladimir. Tue .
"Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease". United States. https://www.osti.gov/servlets/purl/1160128.
@article{osti_1160128,
title = {Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease},
author = {Wright, Ernest M and Barrio, Jorge R and Hirayama, Bruce A and Kepe, Vladimir},
abstractNote = {Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {9}
}
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