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Title: Tracers for monitoring the activity of sodium/glucose cotransporters in health and disease

Radiolabeled tracers for sodium/glucose cotransporters (SGLTs), their synthesis, and their use are provided. The tracers are methyl or ethyl pyranosides having an equatorial hydroxyl group at carbon-2 and a C 1 preferred conformation, radiolabeled with .sup.18F, .sup.123I, or .sup.124I, or free hexoses radiolabeled with .sup.18F, .sup.123I, or .sup.124. Also provided are in vivo and in vitro techniques for using these and other tracers as analytical and diagnostic tools to study glucose transport, in health and disease, and to evaluate therapeutic interventions.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1160128
Assignee:
The Regents of the University of California (Oakland, CA) OAK
Patent Number(s):
8,845,999
Application Number:
11/920,904
Contract Number:
FC03-02ER63420
Resource Relation:
Patent File Date: 2006 May 23
Research Org:
University of California, Oakland, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
60 APPLIED LIFE SCIENCES

Works referenced in this record:

Fluorinated carbohydrates : Part XII. 4-deoxy-4-fluoro-D-glucose: an improved synthesis and the glycosyl fluoride derivatives
journal, August 1971

An alternative synthesis of 4-deoxy-4-fluoro-d-glucose and its transport in the human erythrocyte
journal, August 1979