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Title: Method for enhancing the resolving power of ion mobility separations over a limited mobility range

A method for raising the resolving power, specificity, and peak capacity of conventional ion mobility spectrometry is disclosed. Ions are separated in a dynamic electric field comprising an oscillatory field wave and opposing static field, or at least two counter propagating waves with different parameters (amplitude, profile, frequency, or speed). As the functional dependencies of mean drift velocity on the ion mobility in a wave and static field or in unequal waves differ, only single species is equilibrated while others drift in either direction and are mobility-separated. An ion mobility spectrum over a limited range is then acquired by measuring ion drift times through a fixed distance inside the gas-filled enclosure. The resolving power in the vicinity of equilibrium mobility substantially exceeds that for known traveling-wave or drift-tube IMS separations, with spectra over wider ranges obtainable by stitching multiple segments. The approach also enables low-cutoff, high-cutoff, and bandpass ion mobility filters.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1159843
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
Patent Number(s):
8,841,608
Application Number:
13/861,511
Contract Number:
AC05-76RLO1830
Research Org:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Other works cited in this record:

Fundamentals of Traveling Wave Ion Mobility Spectrometry
journal, December 2008
  • Shvartsburg, Alexandre A.; Smith, Richard D.
  • Analytical Chemistry, Vol. 80, Issue 24, p. 9689-9699
  • DOI: 10.1021/ac8016295

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