Magnetic resonance imaging of self-assembled biomaterial scaffolds

Bull, Steve R.; Meade, Thomas J.; Stupp, Samuel I.

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Title: Magnetic resonance imaging of self-assembled biomaterial scaffolds

Abstract

Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.

Inventors:: Bull, Steve R.; Meade, Thomas J.; Stupp, Samuel I.

Issue Date:: 2014-09-16

Research Org.:: Northwestern Univ., Evanston, IL (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1159832

Patent Number(s):: 8834840

Application Number:: 11/906,825

Assignee:: Northwestern University (Evanston, IL)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES

Show more

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K38/03 - Peptides having up to 20 amino acids in an undefined or only partially defined sequence
A61K38/07 - Tetrapeptides
A61K49/103 - {the complex-forming compound being acyclic, e.g. DTPA}
A61K49/105 - {the metal complex being Gd-DTPA}
A61K49/108 - {the metal complex being Gd-DOTA}

C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
C07K7/06 - having 5 to 11 amino acids

G - PHYSICS G01 - MEASURING G01R - MEASURING ELECTRIC VARIABLES
G01R33/5601 - {involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent}

Show less

DOE Contract Number:: FG02-00ER45810

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007 Oct 04

Country of Publication:: United States

Language:: English

Subject:: 36 MATERIALS SCIENCE

Citation Formats


                    Bull, Steve R., Meade, Thomas J., and Stupp, Samuel I. Magnetic resonance imaging of self-assembled biomaterial scaffolds.  United States: N. p., 2014. 
        Web.

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                    Bull, Steve R., Meade, Thomas J., & Stupp, Samuel I. Magnetic resonance imaging of self-assembled biomaterial scaffolds.  United States.

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                    Bull, Steve R., Meade, Thomas J., and Stupp, Samuel I. Tue .  
        "Magnetic resonance imaging of self-assembled biomaterial scaffolds".  United States.  https://www.osti.gov/servlets/purl/1159832.

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@article{osti_1159832,

  title        = {Magnetic resonance imaging of self-assembled biomaterial scaffolds},

  author       = {Bull, Steve R. and Meade, Thomas J. and Stupp, Samuel I.},

  abstractNote = {Compositions and/or mixtures comprising peptide amphiphile compounds comprising one or more contrast agents, as can be used in a range of magnetic resonance imaging applications.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {9}

}

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Similar Records

Title: Magnetic resonance imaging of self-assembled biomaterial scaffolds

Abstract

Citation Formats

From monomers to micelles: investigation of the parameters influencing proton relaxivity journal, September 2002

Relaxivity of MRI Contrast Agents book, January 2002

Self-Assembled Peptide Amphiphile Nanofibers Conjugated to MRI Contrast Agents journal, January 2005

Noninvasive in Vivo Monitoring of Drug Release and Polymer Erosion from Biodegradable Polymers by EPR Spectroscopy and NMR Imaging journal, January 1997

In Vitro/In Vivo Comparison of Drug Release and Polymer Erosion from Biodegradable P(FAD-SA) Polyanhydrides—A Noninvasive Approach by the Combined Use of Electron Paramagnetic Resonance Spectroscopy and Nuclear Magnetic Resonance Imaging journal, January 1997

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor patent, September 1999

Hydrogels for Tissue Engineering journal, July 2001

Coassembly of Amphiphiles with Opposite Peptide Polarities into Nanofibers journal, February 2005

Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction journal, June 2003

Self-assembling amphiphiles for construction of peptide secondary structures patent, August 2000

Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents journal, January 1994

Macrocyclic magnetic resonance imaging contrast agents patent, December 2003

Polypeptides with fibronectin activity patent, June 1989

Preparation of the very acid-sensitive Fmoc-Lys(Mtt)-OH Application in the synthesis of side-chain to side-chain cyclic peptides and oligolysine cores suitable for the solid-phase assembly of MAPs and TASPs journal, May 1995

The Transferrin Receptor: A Potential Molecular Imaging Marker for Human Cancer journal, November 2003

Novel peptide-based biomaterial scaffolds for tissue engineering journal, January 2002

Mechanistic Studies of a Calcium-Dependent MRI Contrast Agent journal, July 2002

Method for treating ischemia using polypeptides with fibronectin activity patent, November 1998

Solid-Phase Synthesis of DOTA–Peptides journal, March 2004

In vivo visualization of gene expression using magnetic resonance imaging journal, March 2000

Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials journal, April 2002

New magnetic resonance contrast agents as biochemical reporters journal, October 2003

Delivery of contrast agents for magnetic resonance imaging, computed tomography, nuclear medicine and ultrasound journal, April 1999

Physicians’ Views Of The Relative Importance Of Thirty Medical Innovations journal, September 2001

Can Magnetic Resonance Imaging Be the Key Technique to Visualize and Investigate Endovascular Biomaterials? journal, January 2004

Fluorescently Detectable Magnetic Resonance Imaging Agents journal, March 1998

Computed circular dichroism spectra for the evaluation of protein conformation journal, October 1969

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof patent, November 2008

Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers journal, February 2004

Magnetic resonance imaging of controlled release pharmaceutical dosage forms journal, April 1998

Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications journal, September 1999

Designing materials for biology and medicine journal, April 2004

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof patent-application, September 2005

Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3 in Complex with an Arg-Gly-Asp Ligand journal, March 2002

New approaches to biomaterials design journal, November 2004

Contrast enhancing agents for magnetic resonance images patent, June 1990

In vivo monitoring of the degradation process of bioresorbable polymeric implants using magnetic resonance imaging journal, January 1997

Nuclear magnetic resonance contrast agents patent, December 1997

Presentation and Recognition of Biotin on Nanofibers Formed by Branched Peptide Amphiphiles journal, February 2005

Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers journal, November 2001

Polypeptides with fibronectin activity patent, May 1991

Self-assembly of peptide-amphiphile nanofibers under physiological conditions patent-application, January 2004

Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces journal, October 2003

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule journal, May 1984

Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent journal, March 1984

In Vivo Magnetic Resonance Imaging and Relaxometry Study of a Porous Hydrogel Implanted in the Trapezius Muscle of Rabbits journal, June 2000

Fabrication of novel biomaterials through molecular self-assembly journal, September 2003

RGD mimetic γ-AApeptides and methods of use patent, January 2016

Methods of synthesizing γ-aapeptides, γ-aapeptide building blocks, γ-aapeptide libraries, and γ-aapeptide inhibitors of Aβ40 aggregates patent, May 2017

From monomers to micelles: investigation of the parameters influencing proton relaxivity
journal, September 2002

Relaxivity of MRI Contrast Agents
book, January 2002

Self-Assembled Peptide Amphiphile Nanofibers Conjugated to MRI Contrast Agents
journal, January 2005

Noninvasive in Vivo Monitoring of Drug Release and Polymer Erosion from Biodegradable Polymers by EPR Spectroscopy and NMR Imaging
journal, January 1997

In Vitro/In Vivo Comparison of Drug Release and Polymer Erosion from Biodegradable P(FAD-SA) Polyanhydrides—A Noninvasive Approach by the Combined Use of Electron Paramagnetic Resonance Spectroscopy and Nuclear Magnetic Resonance Imaging
journal, January 1997

Stable macroscopic membranes formed by self-assembly of amphiphilic peptides and uses therefor
patent, September 1999

Hydrogels for Tissue Engineering
journal, July 2001

Coassembly of Amphiphiles with Opposite Peptide Polarities into Nanofibers
journal, February 2005

Self-Assembly Combining Two Bioactive Peptide-Amphiphile Molecules into Nanofibers by Electrostatic Attraction
journal, June 2003

Self-assembling amphiphiles for construction of peptide secondary structures
patent, August 2000

Dendrimer-based metal chelates: A new class of magnetic resonance imaging contrast agents
journal, January 1994

Macrocyclic magnetic resonance imaging contrast agents
patent, December 2003

Polypeptides with fibronectin activity
patent, June 1989

Preparation of the very acid-sensitive Fmoc-Lys(Mtt)-OH Application in the synthesis of side-chain to side-chain cyclic peptides and oligolysine cores suitable for the solid-phase assembly of MAPs and TASPs
journal, May 1995

The Transferrin Receptor: A Potential Molecular Imaging Marker for Human Cancer
journal, November 2003

Novel peptide-based biomaterial scaffolds for tissue engineering
journal, January 2002

Mechanistic Studies of a Calcium-Dependent MRI Contrast Agent
journal, July 2002

Method for treating ischemia using polypeptides with fibronectin activity
patent, November 1998

Solid-Phase Synthesis of DOTA–Peptides
journal, March 2004

In vivo visualization of gene expression using magnetic resonance imaging
journal, March 2000

Peptide-amphiphile nanofibers: A versatile scaffold for the preparation of self-assembling materials
journal, April 2002

New magnetic resonance contrast agents as biochemical reporters
journal, October 2003

Delivery of contrast agents for magnetic resonance imaging, computed tomography, nuclear medicine and ultrasound
journal, April 1999

Physicians’ Views Of The Relative Importance Of Thirty Medical Innovations
journal, September 2001

Can Magnetic Resonance Imaging Be the Key Technique to Visualize and Investigate Endovascular Biomaterials?
journal, January 2004

Fluorescently Detectable Magnetic Resonance Imaging Agents
journal, March 1998

Computed circular dichroism spectra for the evaluation of protein conformation
journal, October 1969

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
patent, November 2008

Selective Differentiation of Neural Progenitor Cells by High-Epitope Density Nanofibers
journal, February 2004

Magnetic resonance imaging of controlled release pharmaceutical dosage forms
journal, April 1998

Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications
journal, September 1999

Designing materials for biology and medicine
journal, April 2004

Branched peptide amphiphiles, related epitope compounds and self assembled structures thereof
patent-application, September 2005

Crystal Structure of the Extracellular Segment of Integrin alpha Vbeta 3 in Complex with an Arg-Gly-Asp Ligand
journal, March 2002

New approaches to biomaterials design
journal, November 2004

Contrast enhancing agents for magnetic resonance images
patent, June 1990

In vivo monitoring of the degradation process of bioresorbable polymeric implants using magnetic resonance imaging
journal, January 1997

Nuclear magnetic resonance contrast agents
patent, December 1997

Presentation and Recognition of Biotin on Nanofibers Formed by Branched Peptide Amphiphiles
journal, February 2005

Self-Assembly and Mineralization of Peptide-Amphiphile Nanofibers
journal, November 2001

Polypeptides with fibronectin activity
patent, May 1991

Self-assembly of peptide-amphiphile nanofibers under physiological conditions
patent-application, January 2004

Aqueous Self-Assembly of Unsymmetric Peptide Bolaamphiphiles into Nanofibers with Hydrophilic Cores and Surfaces
journal, October 2003

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule
journal, May 1984

Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent
journal, March 1984

In Vivo Magnetic Resonance Imaging and Relaxometry Study of a Porous Hydrogel Implanted in the Trapezius Muscle of Rabbits
journal, June 2000

Fabrication of novel biomaterials through molecular self-assembly
journal, September 2003

RGD mimetic γ-AApeptides and methods of use
patent, January 2016

Methods of synthesizing γ-aapeptides, γ-aapeptide building blocks, γ-aapeptide libraries, and γ-aapeptide inhibitors of Aβ40 aggregates
patent, May 2017