Medical implants and methods of making medical implants

Title: Medical implants and methods of making medical implants

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Inventors:: Shaw, Wendy J; Yonker, Clement R; Fulton, John L; Tarasevich, Barbara J; McClain, James B; Taylor, Doug

Issue Date:: 2014-09-16

OSTI Identifier:: 1159830

Assignee:: Battelle Memorial Institute (Richland, WA) PNNL

Patent Number(s):: 8,834,913

Application Number:: 12/648,106

Contract Number:: AC06-76RLO1830

Research Org:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING

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Other works cited in this record:

Supercritical fluid molecular spray thin films and fine powders
patent, March 1988

Smith, Richard
US Patent Document 4,734,451
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F4734451

Stents with hybrid coating for medical devices
patent, May 2001

Zhong, Sheng-ping
US Patent Document 6,231,600
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6231600

Implant coating for control of tissue/implant interactions
patent, December 2002

Moussy, Francis; Kreutzer, Donald; Burgess, Diane
US Patent Document 6,497,729
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6497729

Prodrug research: futile or fertile?
journal, December 2004

Testa, Bernard
Biochemical Pharmacology, Vol. 68, Issue 11, p. 2097-2106
DOI: 10.1016/j.bcp.2004.07.005

Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer
journal, December 2005

Chen, Hong; Chen, Yang; Sheardown, Heather
Biomaterials, Vol. 26, Issue 35, p. 7418-7424
DOI: 10.1016/j.biomaterials.2005.05.053

Antibiotics for preventing recurrent urinary tract infection in non-pregnant women
journal, July 2004

Albert, Xavier; Huertas, Isabel; Pereiro, Inmaculado
Cochrane Database of Systematic Reviews
DOI: 10.1002/14651858.CD001209.pub2

Chemical imaging of drug eluting coatings: Combining surface analysis and confocal Raman microscopy
journal, March 2008

Belu, Anna; Mahoney, Christine; Wormuth, Klaus
Journal of Controlled Release, Vol. 126, Issue 2, p. 111-121
DOI: 10.1016/j.jconrel.2007.11.015

A recombinant human enzyme for enhanced interstitial transport of therapeutics
journal, August 2006

Bookbinder, L. H.; Hofer, A.; Haller, M. F.
Journal of Controlled Release, Vol. 114, Issue 2, p. 230-241
DOI: 10.1016/j.jconrel.2006.05.027

Precipitation of ultrafine organic crystals from the rapid expansion of supercritical solutions over a capillary and a frit nozzle
journal, April 1997

Domingo, Concepción; Berends, Edwin; van Rosmalen, Gerda Maria
The Journal of Supercritical Fluids, Vol. 10, Issue 1, p. 39-55
DOI: 10.1016/S0896-8446(97)00011-9

Conscious sedation for gastroscopy: Patient tolerance and cardiorespiratory parameters
journal, March 1995

Froehlich, Florian; Schwizer, Werner; Thorens, Joël
Gastroenterology, Vol. 108, Issue 3, p. 697-704
DOI: 10.1016/0016-5085(95)90441-7

Thin fluoropolymer films and nanoparticle coatings from the rapid expansion of supercritical carbon dioxide solutions with electrostatic collection
journal, June 2003

Fulton, John L.; Deverman, George S.; Yonker, Clement R.
Polymer, Vol. 44, Issue 13, p. 3627-3632
DOI: 10.1016/S0032-3861(03)00280-5

Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion
journal, June 2008

Hamilos, Michalis I.; Ostojic, Miodrag; Beleslin, Branko
Journal of the American College of Cardiology, Vol. 51, Issue 22, p. 2123-2129
DOI: 10.1016/j.jacc.2007.12.059

Tubo-ovarian Abscess in Virginal Adolescents: Exposure of the Underlying Etiology
journal, June 2009

Hartmann, K. A.; Lerand, S. J.; Jay, M. S.
Journal of Pediatric and Adolescent Gynecology, Vol. 22, Issue 3, p. e13-e16
DOI: 10.1016/j.jpag.2008.03.006

Nylon 6/Na–montmorillonite nanocomposites prepared by compounding Nylon 6 with Na–montmorillonite slurry
journal, May 2003

Hasegawa, Naoki; Okamoto, Hirotaka; Kato, Makoto
Polymer, Vol. 44, Issue 10, p. 2933-2937
DOI: 10.1016/S0032-3861(03)00215-5

Characterization of perivascular poly(lactic-co-glycolic acid) films containing paclitaxel
journal, September 2004

Jackson, John K.; Smith, Janet; Letchford, Kevin
International Journal of Pharmaceutics, Vol. 283, Issue 1-2, p. 97-109
DOI: 10.1016/j.ijpharm.2004.06.025

Cyclic acetals of 4,1′,6′-trichloro-4,1′,6′-trideoxy-galacto-sucrose and their conversion into methyl ether derivatives
journal, May 1990

Khan, Riaz; Patel, Gita
Carbohydrate Research, Vol. 198, Issue 2, p. 275-283
DOI: 10.1016/0008-6215(90)84298-9

Enzymic regioselective hydrolysis of peracetylated reducing disaccharides, specifically at the anomeric centre: Intermediates for the synthesis of oligosaccharides.
journal, November 1993

Khan, Riaz; Gropen, Line; Konowicz, Paul A.
Tetrahedron Letters, Vol. 34, Issue 48, p. 7767-7770
DOI: 10.1016/S0040-4039(00)61561-7

Adhesion and permeability of polyimide-clay nanocomposite films for protective coatings
journal, June 2003

Khayankarn, Orasa; Magaraphan, Rathanawan; Schwank, Johannes W.
Journal of Applied Polymer Science, Vol. 89, Issue 11, p. 2875-2881
DOI: 10.1002/app.12326

Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemodynamic instability
journal, June 2009

Kurt, Mevlut; Oztas, Erkin; Kuran, Sedef
The American Journal of Emergency Medicine, Vol. 27, Issue 5, p. 631.e1-631.e2
DOI: 10.1016/j.ajem.2008.09.003

Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study
journal, September 2003

Mehik, Aare; Alas, Peeter; Nickel, J. Curtis
Urology, Vol. 62, Issue 3, p. 425-429
DOI: 10.1016/S0090-4295(03)00466-7

Synthetic biodegradable polymers as orthopedic devices
journal, December 2000

Middleton, John C.; Tipton, Arthur J.
Biomaterials, Vol. 21, Issue 23, p. 2335-2346
DOI: 10.1016/S0142-9612(00)00101-0

Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent
journal, April 2000

Mishima, Kenji; Matsuyama, Kiyoshi; Tanabe, Daisaku
AIChE Journal, Vol. 46, Issue 4, p. 857-865
DOI: 10.1002/aic.690460418

Pharos neurovascular intracranial stent: Elective use for a symptomatic stenosis refractory to medical therapy
journal, October 2009

Mocco, J.; Darkhabani, Ziad; Levy, Elad I.
Catheterization and Cardiovascular Interventions, Vol. 74, Issue 4, p. 642-646
DOI: 10.1002/ccd.22054

Extracellular matrix binding mixed micelles for drug delivery applications
journal, July 2009

O'Neil, Conlin P.; van der Vlies, André J.; Velluto, Diana
Journal of Controlled Release, Vol. 137, Issue 2, p. 146-151
DOI: 10.1016/j.jconrel.2009.03.013

Tubers and tumors: rapamycin therapy for benign and malignant tumors
journal, April 2009

Plas, David R.; Thomas, George
Current Opinion in Cell Biology, Vol. 21, Issue 2, p. 230-236
DOI: 10.1016/j.ceb.2008.12.013

Inflammation and anti-inflammatory therapy in chronic prostatitis
journal, December 2002

Pontari, Michel
Urology, Vol. 60, Issue 6, p. 29-33
DOI: 10.1016/S0090-4295(02)02381-6

A comparison of the mechanical performance characteristics of seven drug-eluting stent systems
journal, February 2009

Schmidt, W.; Lanzer, P.; Behrens, P.
Catheterization and Cardiovascular Interventions, Vol. 73, Issue 3, p. 350-360
DOI: 10.1002/ccd.21832

Topical Heparin: A Promising Agent for the Prevention of Tracheal Stenosis in Airway Surgery
journal, November 2009

Sen, Serdar; Meteoglu, Ibrahim; Ogurlu, Mustafa
Journal of Surgical Research, Vol. 157, Issue 1, p. e23-e29
DOI: 10.1016/j.jss.2009.01.028

Long-term Experience With Bacillus Calmette-Guerin Therapy of Upper Urinary Tract Transitional Cell Carcinoma in Patients Not Eligible for Surgery
journal, October 2002

Thalmann, George N.; Markwalder, Regula; Walter, Bernhard
The Journal of Urology, Vol. 168, Issue 4, p. 1381-1385
DOI: 10.1016/S0022-5347(05)64454-0

Poly(ethylene carbonate): A thermoelastic and biodegradable biomaterial for drug eluting stent coatings?
journal, February 2007

Unger, F.; Westedt, U.; Hanefeld, P.
Journal of Controlled Release, Vol. 117, Issue 3, p. 312-321
DOI: 10.1016/j.jconrel.2006.11.003

A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study
journal, September 2009

Wagenlehner, Florian M. E.; Schneider, Henning; Ludwig, Martin
European Urology, Vol. 56, Issue 3, p. 544-551
DOI: 10.1016/j.eururo.2009.05.046

Controlled release of sirolimus from a multilayered PLGA stent matrix
journal, November 2006

Wang, Xintong; Venkatraman, Subbu S.; Boey, Freddy Y. C.
Biomaterials, Vol. 27, Issue 32, p. 5588-5595
DOI: 10.1016/j.biomaterials.2006.07.016

Treatment with melagatran alone or in combination with thrombolytic therapy reduced ischemic brain injury
journal, September 2008

Wang, Chen Xu; Ding, Xiuqing; Shuaib, Ashfaq
Experimental Neurology, Vol. 213, Issue 1, p. 171-175
DOI: 10.1016/j.expneurol.2008.05.020

Intravesical Pharmacotherapy for Non–Muscle-Invasive Bladder Cancer: A Critical Analysis of Currently Available Drugs, Treatment Schedules, and Long-Term Results
journal, January 2008

Witjes, J. Alfred; Hendricksen, Kees
European Urology, Vol. 53, Issue 1, p. 45-52
DOI: 10.1016/j.eururo.2007.08.015

Biodegradation of poly(l-lactide-co-glycolide) tube stents in bile
journal, April 2008

Xu, Xiaoyi; Liu, Tongjun; Zhang, Kai
Polymer Degradation and Stability, Vol. 93, Issue 4, p. 811-817
DOI: 10.1016/j.polymdegradstab.2008.01.022

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic
journal, January 2009

Yepes, Manuel; Roussel, Benoit D.; Ali, Carine
Trends in Neurosciences, Vol. 32, Issue 1, p. 48-55
DOI: 10.1016/j.tins.2008.09.006

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
journal, January 2009

Yousuf, Seema; Atif, Fahim; Ahmad, Muzamil
Brain Research, Vol. 1250, p. 242-253
DOI: 10.1016/j.brainres.2008.10.068

Synthesis and characterization of biodegradable low molecular weight aliphatic polyesters and their use in protein-delivery systems
journal, January 2003

Zhou, Shaobing; Deng, Xianmo; Li, Xiaohong
Journal of Applied Polymer Science, Vol. 91, Issue 3, p. 1848-1856
DOI: 10.1002/app.13385

Selection of coronary stents
journal, September 2002

Colombo, Antonio; Stankovic, Goran; Moses, Jeffrey W.
Journal of the American College of Cardiology, Vol. 40, Issue 6, p. 1021-1033
DOI: 10.1016/S0735-1097(02)02123-X

A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies
journal, November 2009

Koh, Li Buay; Rodriguez, Isabel; Venkatraman, Subbu S.
Acta Biomaterialia, Vol. 5, Issue 9, p. 3411-3422
DOI: 10.1016/j.actbio.2009.06.003

Crystallization processes in pharmaceutical technology and drug delivery design
journal, April 2000

Shekunov, B. Yu.; York, P.
Journal of Crystal Growth, Vol. 211, Issue 1-4, p. 122-136
DOI: 10.1016/S0022-0248(99)00819-2

Study on the preparation and characterization of biodegradable polylactide/multi-walled carbon nanotubes nanocomposites
journal, July 2007

Wu, Chin-San; Liao, Hsin-Tzu
Polymer, Vol. 48, Issue 15, p. 4449-4458
DOI: 10.1016/j.polymer.2007.06.004

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