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Title: Medical implants and methods of making medical implants

Abstract

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1159830
Patent Number(s):
8,834,913
Application Number:
12/648,106
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC06-76RL01830
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
42 ENGINEERING

Citation Formats

Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, and Taylor, Doug. Medical implants and methods of making medical implants. United States: N. p., 2014. Web.
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, & Taylor, Doug. Medical implants and methods of making medical implants. United States.
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, and Taylor, Doug. Tue . "Medical implants and methods of making medical implants". United States. https://www.osti.gov/servlets/purl/1159830.
@article{osti_1159830,
title = {Medical implants and methods of making medical implants},
author = {Shaw, Wendy J and Yonker, Clement R and Fulton, John L and Tarasevich, Barbara J and McClain, James B and Taylor, Doug},
abstractNote = {A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {9}
}

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