Medical implants and methods of making medical implants
Abstract
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1159830
- Patent Number(s):
- 8834913
- Application Number:
- 12/648,106
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 42 ENGINEERING
Citation Formats
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, and Taylor, Doug. Medical implants and methods of making medical implants. United States: N. p., 2014.
Web.
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, & Taylor, Doug. Medical implants and methods of making medical implants. United States.
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, and Taylor, Doug. Tue .
"Medical implants and methods of making medical implants". United States. https://www.osti.gov/servlets/purl/1159830.
@article{osti_1159830,
title = {Medical implants and methods of making medical implants},
author = {Shaw, Wendy J and Yonker, Clement R and Fulton, John L and Tarasevich, Barbara J and McClain, James B and Taylor, Doug},
abstractNote = {A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {9}
}
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Works referenced in this record:
Stents with hybrid coating for medical devices
patent, May 2001
- Zhong, Sheng-ping
- US Patent Document 6,231,600
Implant coating for control of tissue/implant interactions
patent, December 2002
- Moussy, Francis; Kreutzer, Donald; Burgess, Diane
- US Patent Document 6,497,729
Compressed microparticles for dry injection
patent-application, October 2001
- Boutignon, Francois
- US Patent Application 09/764111; 20010026804
Thromboresistant coating composition
patent-application, October 2001
- Shah, Chirag B.; Wolfgang, Laurel L.
- US Patent Application 09/862710; 20010034336
Polymer Coated Stent
patent-application, December 2001
- Tseng, David; Donahue, William; Parsons, Bruce A.
- US Patent Application 09/272538; 20010049551
Method and apparatus for interference cancellation in a rake receiver
patent-application, May 2002
- Bottomley, Gregory E.
- US Patent Application 09/992094; 20020051485
Drug release coated stent
patent-application, July 2002
- Ding, Ni; Helmus, Michael
- US Patent Application 10/022607; 20020091433
Biodegradable polymeric endoluminal sealing process, apparatus and polymeric products for use therein
patent-application, July 2002
- Slepian, Marvin J.; Schindler, Anton
- US Patent Application 10/020083; 20020099332
Mains-independent power supply unit
patent-application, September 2002
- Schworm, Ernst; Steiner, Guenther
- US Patent Application 10/076715; 20020125860
Graft polymerization of substrate surfaces
patent-application, September 2002
- Wang, Guo-Bin; Zhang, Xianping
- US Patent Application 10/035561; 20020133072
Stainless steel alloy with improved radiopaque characteristics
patent-application, October 2002
- Craig, Charles Horace; Radisch, Herbert R.; Trozera, Thomas
- U.S. Patent Application 10/103411; 20020144757
Dynamic device for billboard advertising
patent-application, January 2003
- Wampler, Scott D.; Wampler, James W.; Vaitekunas, Jeffrey J.
- US Patent Application 10/175057; 20030001830
Polymer compositions containing bioactive agents and methods for their use
patent-application, February 2003
- Van Antwerp, William P.
- US Patent Application 10/260786; 20030031699
Enhanced radiopaque alloy stent
patent-application, April 2003
- Craig, Charles H,; Trozera, Thomas A.; Radisch, JR., Herbert R.
- US Patent Application 10/112390; 20030077200
Potent coatings for stents
patent-application, May 2003
- Shulze, John E.; Betts, Ronald E.; Savage, Douglas R.
- US Patent Application 10/150909; 20030088307
Drug-delivery endovascular stent and method for treating restenosis
patent-application, July 2003
- Shulze, John E.; Betts, Ronald E.; Savage, Douglas R.
- US Patent Application 10/133814; 20030125800
Coating medical devices
patent-application, July 2003
- Pui, David Y. H.; Chen, Da-Ren
- US Patent Application 10/301473; 20030143315
Slow release pharmaceutical preparation and method of administering same
patent-application, September 2003
- O'Neil, Alexander George B.; Liu, Yandi
- US Patent Application 10/363107; 20030170305
Porous beta-tricalcium phosphate granules and methods for producing same
patent-application, September 2003
- Dalal, Paresh S.; Dimaano, Godofredo R.; Toth, Carol Ann
- US Patent Application 09/960789; 20030180376
Method for spray-coating a medical device having a tubular wall such as a stent
patent-application, October 2003
- Weber, Jan; Kocur, Gordon John
- US Patent Application 10/109073; 20030185964
Coated stent with crimpable coating
patent-application, October 2003
- Tedeschi, Eugene
- US Patent Application 10/133156; 20030204238
Electrostatic deposition of particles generated from rapid expansion of supercritical fluid solutions
patent-application, December 2003
- Fulton, John L.; Deverman, George
- US Patent Application 10/156970; 20030222017
Methods for producing films using supercritical fluid
patent-application, December 2003
- Yonker, Clement R.; Fulton, John L.
- US Patent Application 10/157591; 20030222018
Phosphorylated proteins and uses related thereto
patent-application, December 2003
- Burke, Daniel J.; Ross, Mark M.; Stukenberg, P. Todd
- US Patent Application 10/378173; 20030232014
Stent coating holders
patent-application, January 2004
- Epstein, Samuel; Hansen, Henrik; Coyle, Simon
- US Patent Application 10/198094; 20040013792
Compositions and methods for reducing scar tissue formation
patent-application, January 2004
- Fischell, Robert E.; Fischell, Tim A.; Fischell, Sarah T.
- US Patent Application 10/431701; 20040018228
Polymer-based, sustained release drug delivery system
patent-application, February 2004
- Ashton, Paul; Chen, Jianbing; Guo, Hong
- US Patent Application 10/449855; 20040022853
Medical devices and methods of making the same
patent-application, March 2004
- Stinson, Jonathan S.
- US Patent Application 10/229548; 20040044397
Multi-balloon catheter with hydrogel coating
patent-application, March 2004
- Palasis, Maria
- US Patent Application 10/253597; 20040059290
Multilayer stent
patent-application, June 2004
- Jalisi, Marc M.
- US Patent Application 10/618149; 20040106982
Alkyd-lactone copolymers for medical applications
patent-application, June 2004
- Nathan, Aruna
- US Patent Application 10/322132; 20040122205
Pressure-sensitive adhesive tape or sheet
patent-application, July 2004
- Fujiwara, Shuzo; Shirai, Masato; Kawaguchi, Yoshihide
- US Patent Application 10/624500; 20040126542
Medical devices
patent-application, July 2004
- Stinson, JOnathan S.; Vanderlaan, Robert A.
- US Patent Application 10/346487; 20040143317
Method for freeze-drying nucleic acid/block copolymer/cationic surfactant complexes
patent-application, August 2004
- , Andrew Geall
- US Patent Application 10/725009; 20040157789
Modified delivery device for coated medical devices
patent-application, September 2004
- Houghton, Michael J.; Majereak, David C.
- US Patent Application 10/403195; 20040193177
Implants for treating ocular hypertension, methods of use and methods of fabrication
patent-application, September 2004
- Shadduck, John H.
- US Patent Application 10/770436; 20040193262
Bioresorbable stent with beneficial agent reservoirs
patent-application, November 2004
- Shanley, John F.; Litvack, Frank; Parker, Theodore L.
- US Patent Application 10/822063; 20040220660
Stent coatings comprising hydrophilic additives
patent-application, November 2004
- Pacetti, Stephen D.; Tang, Yiwen
- US Patent Application 10/431711; 20040224001
Increased biocompatibility of implantable medical devices
patent-application, November 2004
- Robert, Falotico
- US Patent Application 10/848090; 20040236416
Polyolefin nanocomposites
patent-application, December 2004
- Chaiko, David J.
- US Patent Application 10/874774; 20040260000
Method and apparatus for the coating of substrates for pharmaceutical use
patent-application, January 2005
- Brown, Steven R.; Reeves, Linda A.; Staniforth, John N.
- US Patent Application 10/892238; 20050003074
Stents with drug-containing amphiphilic polymer coating
patent-application, January 2005
- Lewis, Andrew L.; Leppard, Simon W.
- US Patent Application 10/466144; 20050004661
Implantable medical devices
patent-application, January 2005
- Sahatjian, Ronald A.; Tan, Francisca; Mather, Patrick
- US Patent Application 10/683314; 20050010275
Medical devices and processes for preparing same
patent-application, January 2005
- Weber, Jan; Schewe, Scott; Burgmeier, Robert E.
- US Patent Application 10/622621; 20050015046
Nanoliter-scale synthesis of arrayed biomaterials and screening thereof
patent-application, January 2005
- Anderson, Daniel G.; Levenberg, Shulamit; Langer, Robert S.
- US Patent Application 10/843707; 20050019747
Medical device applications of nanostructured surfaces
patent-application, February 2005
- Dubrow, Robert S.; Sloan, L. Douglas; Kronenthal, Richard L.
- US Patent Application 10/902700; 20050038498
High molecular wegiht polymers, devices and method for making and using same
patent-application, March 2005
- East, Anthony; Letton, Alan J.; Kanamathareddy, Suseela
- US Patent Application 10/861881; 20050048121
Extrusion process for coating stents
patent-application, March 2005
- Neary, Anthony J.
- US Patent Application 10/636865; 20050049694
Thrombosis inhibiting graft
patent-application, February 2007
- Furst, Joseph G.; Brodbeck, William G.
- US Patent Application 11/283434; 20070032864
Method and device for extracting objects from the body
patent-application, February 2007
- Massicotte, J. Mathieu; Massicott, Peter J.
- US Patent Application 11/503617; 20070038227
Agents for controlling biological fluids and methods of use thereof
patent-application, March 2007
- Kennedy, John P.; Jones, II, Curtis E.
- US Patent Application 11/452090; 20070059350
Coated and imprinted medical devices and methods of making the same
patent-application, May 2007
- Radhakrishnan, Rajesh; Chandrasekaran, Chandru
- US Patent Application 11/274792; 20070110888
Biodegradable device
patent-application, May 2007
- Roth, Noah M.; Kondabatni, Kishore; Karnati, Chandana
- US Patent Application 11/646890; 20070123973
Progenitor endothelial cell capturing with a drug eluting implantable medical device
patent-application, May 2007
- Cottone, Robert John JR.; Yoklavich, Margaret; Parker, Sherry
- US Patent Application 11/560353; 20070123977
Direct coating solid dosage forms using powdered materials
patent-application, June 2007
- Zhu, Jingxu; Luo, Yanfeng; Ma, Ying Liang
- US Patent Application 11/498259; 20070128274
Nanoparticle releasing medical devices
patent-application, June 2007
- Hossainy, Syed Faiyaz Ahmed; Ludwig, Florian Niklas; Sridharan, Srinivasan
- US Patent Application 11/317837; 20070148251
Polymeric compositions comprising therapeutic agents in crystalline phases, and methods of forming the same
patent-application, July 2007
- Burgermeister, Robert; Dave, Vipul
- US Patent Application 11/321255; 20070154554
Implantable medical device coatings with biodegradable elastomer and releasable therapeutic agent
patent-application, August 2007
- Ruane, Patrick H.; Waleska, Perez-Segarra; Reyes, Priscilla
- US Patent Application 11/599850; 20070196423
Poly(butylmethacrylate) and rapamycin coated stent
patent-application, August 2007
- Castro, Daniel; Pacetti, Stephen D.
- US Patent Application 11/634686; 20070198081
Implantable device formed from polymer blends having modified molecular structures
patent-application, August 2007
- Burgermeister, Robert; Dave, Vipul; Narayanan, Pallasana V.
- US Patent Application 11/362492; 20070203569
Medical Device Having Coating With Zeolite Drug Reservoirs
patent-application, November 2007
- , Richard Francis
- US Patent Application 11/381823; 20070259017
Sustained delivery formulations of rapamycin compounds
patent-application, December 2007
- Margaron, Philippe Maria Clotaire; Dadey, Eric; Lindemann, Christopher M.
- US Patent Application 11/706569; 20070280992
Drug delivery devices and methods
patent-application, February 2008
- Chen, Chao-Chin; Dave, Vipul
- US Patent Application 11/435195; 20080051866
Drug Delivery Medical Device
patent-application, January 2010
- McClain, James B.; Taylor, Douglas; Neet, John
- US Patent Application 12/504597; 20100015200
Surgical Sutures Having Increased Strength
patent-application, February 2010
- , Jim McClain
- US Patent Application 12/443959; 20100030261
Bioabsorable Coatings for Medical Devices
patent-application, February 2010
- Yadav, Jay S.; Roth, Noah M.; Kondabatni, Kishore
- US Patent Application 12/544719; 20100042206
Stent Coatings for Reducing Late Stent Thrombosis
patent-application, March 2010
- Betts, Ronald E.; Savage, Douglas R.; Shulze, John E.
- US Patent Application 12/201969; 20100055145
Methods and Apparatus for Coating Balloon Catheters
patent-application, March 2010
- Wang, Jeffrey; Malinoff, Harrison; Wang, Lixiao
- US Patent Application 12/549180; 20100055294
Coating on a Balloon Comprising a Polymer and a Drug
patent-application, March 2010
- Pacetti, Stephen D.; , John Stankus
- US Patent Application 12/205577; 20100063570
Stents Having Biodegradable Layers
patent-application, March 2010
- McClain, James B.; Taylor, Doug; Rabiner, Robert
- US Patent Application 12/522379; 20100063580
Medical Implants with a Combination of Compounds
patent-application, March 2010
- Hunter, William L.
- US Patent Application 12/518962; 20100074934
Electrostatic Spraying Device and a Method of Electrostatic Spraying
patent-application, June 2010
- Stark, John P. W.; Alexander, Matthew S.; Paine, Mark D.
- US Patent Application 12/600625; 20100155496
Methods and Compositions for Treating Pulmonary Hypertension
patent-application, July 2010
- Desai, Neil P.; Soon-Shiong, Patrick
- US Patent Application 12/598406; 20100166869
Polymer-Encapsulated Reverse Micelles
patent-application, August 2010
- Radovic-Moreno, Aleksandar F.; Zhang, Liangfang; Langer, Robert S.
- US Patent Application 12/573411; 20100196482
Bioabsorbable Stent And Treatment That Elicits Time-Varying Host-Material Response
patent-application, August 2010
- Hossainy, Syed F. A.; Rapoza, Richard; Oberhauser, James P.
- US Patent Application 12/506121; 20100198330
Bioabsorbable Stent That Modulates Plaque Geometric Morphology And Chemical Composition
patent-application, August 2010
- Rapoza, Richard; Wang, Yunbing; Oberhauser, James P.
- US Patent Application 12/510076; 20100198331
Stents Having Biodegradable Layers
patent-application, August 2010
- McClain, James B.; Taylor, Douglas
- US Patent Application 12/595848; 20100211164
Polymer Films for Medical Device Coating
patent-application, September 2010
- McClain, James; Taylor, Douglas
- US Patent Application 12/601101; 20100228348
Process and Apparatus for Producing a Coated Product
patent-application, September 2010
- Xing, Baozhong; Eastham, J. David; Wynnyk, Nick P.
- US Patent Application 12/728985; 20100233332
Drug Delivery Medical Device
patent-application, September 2010
- McClain, James B.; Taylor, Douglas; Neet, John
- US Patent Application 12/729580; 20100239635
Peripheral Stents Having Layers
patent-application, September 2010
- McClain, James B.; Taylor, Douglas
- US Patent Application 12/729156; 20100241220
Biodegradable Polymers
patent-application, October 2010
- Taylor, Douglas; McClain, James B.; Schmidt, Edward E.
- US Patent Application 12/729603; 20100256746
Coated Stents
patent-application, October 2010
- Taylor, Douglas; McClain, James B.
- US Patent Application 12/751902; 20100256748
Stents Having Controlled Elution
patent-application, October 2010
- McClain, James B.; Taylor, Douglas
- US Patent Application 12/762007; 20100272778
Drug Coated Stents
patent-application, November 2010
- McClain, James B.; Taylor, Douglas
- US Patent Application 12/738411; 20100298928
Rapamycin Reservoir Eluting Stent
patent-application, January 2011
- Luk, Andrew; Nguyen, Thai Minh; Parker, Theodore L.
- US Patent Application 12/500043; 20110009953
Dendrimers for Sustained Release of Compounds
patent-application, February 2011
- Kannan, Rangaramanujam; Iezzi, Raymond; Rajaguru, Bharath
- US Patent Application 12/681516; 20110034422
Medical Implants and Methods of Making Medical Implants
patent-application, June 2011
- Shaw, Wendy J.; Yonker, Clement R.; Fulton, John L.
- US Patent Application 12/648106; 20110159069
Extraluminal Stent Type Prosthesis for Anastomosis
patent-application, June 2011
- Filho, Granja; Gonzaga, Luiz
- US Patent Application 12/303650; 20110160751
Stent and Stent Delivery System with Improved Deliverability
patent-application, August 2011
- McClain, James B.; Taylor, Douglas; Enscore, David
- US Patent Application 13/014632; 20110190864
System and Method for Enhanced Electrostatic Deposition and Surface Coatings
patent-application, September 2011
- Fulton, John L.; Deverman, George S.; Matson, Dean W.
- US Patent Application 12/748134; 20110238161
Stents Having Controlled Elution
patent-application, October 2011
- McClain, James B.; Taylor, Douglas
- US Patent Application 13/086335; 20110257732
Stents and other devices having extracellular matrix coating
patent-application, October 2011
- McClain, James B.; Benvenuto, Arthur J.
- US Patent Application 13/090525; 20110264190
Manufacture, Method and Use of Drug-Eluting Medical Devices for Permanently Keeping Blood Vessels Open
patent-application, December 2011
- Hoffman, Erika; Hoffman, Michael; Horres, Roland
- US Patent Application 13/161161; 20110301697
Macrolide Dosage Forms
patent-application, March 2012
- McClain, James B.; Taylor, Charles Douglas; Carlyle, Wenda C.
- US Patent Application 13/229473; 20120064124
Inhibition of Mammalian Target of Rapamycin
patent-application, March 2012
- Sharp, Zelton Dave; Strong, John R.; Galvan, Veronica
- US Patent Application 13/128800; 20120064143
Stent Having Improved Stent Design
patent-application, April 2012
- Mews, Steffen; Bakczewitz, Frank
- US Patent Application 13/344142; 20120101566
Drug Delivery Medical Device
patent-application, July 2012
- McClain, James B.; Taylor, Charles Douglas
- US Patent Application 13/384216; 20120172787
Nanoparticle and Surface-Modified Particulate Coatings, Coated Balloons, and Methods Therefore
patent-application, July 2012
- McClain, James B.; Taylor, Charles DOuglas; Zani, Brett G.
- US Patent Application 13/340472; 20120177742
Prodrug research: futile or fertile?
journal, December 2004
- Testa, Bernard
- Biochemical Pharmacology, Vol. 68, Issue 11, p. 2097-2106
Lessons Learned from Marketed and Investigational Prodrugs
journal, May 2004
- Ettmayer, Peter; Amidon, Gordon L.; Clement, Bernd
- Journal of Medicinal Chemistry, Vol. 47, Issue 10
Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer
journal, December 2005
- Chen, Hong; Chen, Yang; Sheardown, Heather
- Biomaterials, Vol. 26, Issue 35, p. 7418-7424
Studies of a novel human thrombomodulin immobilized substrate: surface characterization and anticoagulation activity evaluation
journal, January 2001
- Han, Huai-Song; Yang, Shiao-Ling; Yeh, Hsi-Yi
- Journal of Biomaterials Science, Polymer Edition, Vol. 12, Issue 10
One-Stage Synthesis of Raffinose Fatty Acid Polyesters
journal, November 1987
- Akoh, Casimir C.; Swanson, Barry G.
- Journal of Food Science, Vol. 52, Issue 6
Antibiotics for preventing recurrent urinary tract infection in non-pregnant women
journal, July 2004
- Albert, Xavier; Huertas, Isabel; Pereiro, Inmaculado
- Cochrane Database of Systematic Reviews
Methods to Improve Efficacy of Intravesical Mitomycin C: Results of a Randomized Phase III Trial
journal, April 2001
- Au, J. L. -S.; Badalament, R. A.; Wientjes, M. G.
- JNCI Journal of the National Cancer Institute, Vol. 93, Issue 8
Quantitative spatial distribution of sirolimus and polymers in drug-eluting stents using confocal Raman microscopy
journal, January 2008
- Balss, K. M.; Llanos, G.; Papandreou, G.
- Journal of Biomedical Materials Research Part A, Vol. 85A, Issue 1
Chemical imaging of drug eluting coatings: Combining surface analysis and confocal Raman microscopy
journal, March 2008
- Belu, Anna; Mahoney, Christine; Wormuth, Klaus
- Journal of Controlled Release, Vol. 126, Issue 2, p. 111-121
Topical treatment of chronic prostatitis and premature ejaculation
journal, June 1972
- Boneff, A. N.
- International Urology and Nephrology, Vol. 4, Issue 2
A recombinant human enzyme for enhanced interstitial transport of therapeutics
journal, August 2006
- Bookbinder, L. H.; Hofer, A.; Haller, M. F.
- Journal of Controlled Release, Vol. 114, Issue 2, p. 230-241
Prevention and treatment of urinary tract infection with probiotics: Review and research perspective
journal, January 2008
- Borchert, D.; Sheridan, L.; Papatsoris, A.
- Indian Journal of Urology, Vol. 24, Issue 2
Histamine, a vasoactive agent with vascular disrupting potential, improves tumour response by enhancing local drug delivery
journal, November 2006
- Brunstein, F.; Rens, J.; van Tiel, S. T.
- British Journal of Cancer, Vol. 95, Issue 12
Use of Triclosan-Eluting Ureteral Stents in Patients with Long-Term Stents
journal, July 2009
- Cadieux, Peter A.; Chew, Ben H.; Nott, Linda
- Journal of Endourology, Vol. 23, Issue 7
Intramural Delivery of Rapamycin With α v β 3 -Targeted Paramagnetic Nanoparticles Inhibits Stenosis After Balloon Injury
journal, May 2008
- Cyrus, Tillmann; Zhang, Huiying; Allen, John S.
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 28, Issue 5
Polyanhydrides. I. Preparation of high molecular weight polyanhydrides
journal, December 1987
- Domb, A. J.; Langer, R.
- Journal of Polymer Science Part A: Polymer Chemistry, Vol. 25, Issue 12
Precipitation of ultrafine organic crystals from the rapid expansion of supercritical solutions over a capillary and a frit nozzle
journal, April 1997
- Domingo, Concepción; Berends, Edwin; van Rosmalen, Gerda Maria
- The Journal of Supercritical Fluids, Vol. 10, Issue 1, p. 39-55
Molecular imaging in vivo : an introduction
journal, December 2003
- Dzik-Jurasz, A. S. K.
- The British Journal of Radiology, Vol. 76, Issue suppl_2
Imidazoquinolinone, Imidazopyridine, and Isoquinolindione Derivatives as Novel and Potent Inhibitors of the Poly(ADP-ribose) Polymerase (PARP): A Comparison with Standard PARP Inhibitors
journal, September 2008
- Eltze, Tobias; Boer, Rainer; Wagner, Thomas
- Molecular Pharmacology, Vol. 74, Issue 6
Chronic inflammation in the pathogenesis of benign prostatic hyperplasia: BPH and inflammation
journal, June 2009
- Fibbi, B.; Penna, G.; Morelli, A.
- International Journal of Andrology, Vol. 33, Issue 3
High expression of gastrin-releasing peptide receptors in the vascular bed of urinary tract cancers: promising candidates for vascular targeting applications
journal, June 2009
- Fleischmann, Achim; Waser, Beatrice; Reubi, Jean Claude
- Endocrine-Related Cancer, Vol. 16, Issue 2
Conscious sedation for gastroscopy: Patient tolerance and cardiorespiratory parameters
journal, March 1995
- Froehlich, Florian; Schwizer, Werner; Thorens, Joël
- Gastroenterology, Vol. 108, Issue 3, p. 697-704
Insulin-like growth factor 1 treatment via hydrogels rescues cochlear hair cells from ischemic injury
journal, January 2008
- Fujiwara, Takashi; Hato, Naohito; Nakagawa, Takayuki
- NeuroReport, Vol. 19, Issue 16
Thin fluoropolymer films and nanoparticle coatings from the rapid expansion of supercritical carbon dioxide solutions with electrostatic collection
journal, June 2003
- Fulton, John L.; Deverman, George S.; Yonker, Clement R.
- Polymer, Vol. 44, Issue 13, p. 3627-3632
Simple conjugated polymer nanoparticles as biological labels
journal, June 2009
- Green, Mark; Howes, Philip; Berry, Catherine
- Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, Vol. 465, Issue 2109
On Protein Denaturation in Aqueous−Organic Mixtures but Not in Pure Organic Solvents
journal, January 1996
- Griebenow, Kai; Klibanov, Alexander M.
- Journal of the American Chemical Society, Vol. 118, Issue 47
Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion
journal, June 2008
- Hamilos, Michalis I.; Ostojic, Miodrag; Beleslin, Branko
- Journal of the American College of Cardiology, Vol. 51, Issue 22, p. 2123-2129
Tubo-ovarian Abscess in Virginal Adolescents: Exposure of the Underlying Etiology
journal, June 2009
- Hartmann, K. A.; Lerand, S. J.; Jay, M. S.
- Journal of Pediatric and Adolescent Gynecology, Vol. 22, Issue 3, p. e13-e16
Nylon 6/Na–montmorillonite nanocomposites prepared by compounding Nylon 6 with Na–montmorillonite slurry
journal, May 2003
- Hasegawa, Naoki; Okamoto, Hirotaka; Kato, Makoto
- Polymer, Vol. 44, Issue 10, p. 2933-2937
Can a Topical Microbicide Prevent Rectal HIV Transmission?
journal, August 2008
- Hladik, Florian; Dezzutti, Charlene S.
- PLoS Medicine, Vol. 5, Issue 8
Secondary Structure of Chorion Proteins of the Teleostean Fish Dentex dentex by ATR FT-IR and FT-Raman Spectroscopy
journal, November 2000
- Iconomidou, V. A.; Chryssikos, D. G.; Gionis, V.
- Journal of Structural Biology, Vol. 132, Issue 2
Characterization of perivascular poly(lactic-co-glycolic acid) films containing paclitaxel
journal, September 2004
- Jackson, John K.; Smith, Janet; Letchford, Kevin
- International Journal of Pharmaceutics, Vol. 283, Issue 1-2, p. 97-109
Neointimal hyperplasia after sirolimus-eluting and paclitaxel-eluting stent implantation in diabetic patients: The Randomized Diabetes and Drug-Eluting Stent (DiabeDES) Intravascular Ultrasound Trial
journal, May 2008
- Jensen, L. O.; Maeng, M.; Thayssen, P.
- European Heart Journal, Vol. 29, Issue 22
Release of Plasmid DNA from Intravascular Stents Coated with Ultrathin Multilayered Polyelectrolyte Films
journal, September 2006
- Jewell, Christopher M.; Zhang, Jingtao; Fredin, Nathaniel J.
- Biomacromolecules, Vol. 7, Issue 9
Site-Specific Targeting of Nanoparticle Prednisolone Reduces In-Stent Restenosis in a Rabbit Model of Established Atheroma
journal, November 2008
- Joner, Michael; Morimoto, Katsumi; Kasukawa, Hiroaki
- Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 28, Issue 11
Local delivery of modified paclitaxel-loaded poly(ε-caprolactone)/pluronic F68 nanoparticles for long-term inhibition of hyperplasia
journal, June 2009
- Mei, Lin; Sun, Hongfan; Song, Cunxian
- Journal of Pharmaceutical Sciences, Vol. 98, Issue 6
Stabilization of Proteins in Dry Powder Formulations Using Supercritical Fluid Technology
journal, November 2004
- Jovanović, Nataša; Bouchard, Andréanne; Hofland, Gerard W.
- Pharmaceutical Research, Vol. 21, Issue 11
Bacteriology of Urinary Tract Infection Associated with Indwelling J Ureteral Stents
journal, November 2004
- Kehinde, Elijah O.; Rotimi, Vincent O.; Al-Hunayan, Adel
- Journal of Endourology, Vol. 18, Issue 9
Cyclic acetals of 4,1′,6′-trichloro-4,1′,6′-trideoxy-galacto-sucrose and their conversion into methyl ether derivatives
journal, May 1990
- Khan, Riaz; Patel, Gita
- Carbohydrate Research, Vol. 198, Issue 2, p. 275-283
Chemistry and new uses of sucrose: how important?
journal, January 1984
- Khan, Riaz
- Pure and Applied Chemistry, Vol. 56, Issue 7
Enzymic regioselective hydrolysis of peracetylated reducing disaccharides, specifically at the anomeric centre: Intermediates for the synthesis of oligosaccharides.
journal, November 1993
- Khan, Riaz; Gropen, Line; Konowicz, Paul A.
- Tetrahedron Letters, Vol. 34, Issue 48, p. 7767-7770
Adhesion and permeability of polyimide-clay nanocomposite films for protective coatings
journal, June 2003
- Khayankarn, Orasa; Magaraphan, Rathanawan; Schwank, Johannes W.
- Journal of Applied Polymer Science, Vol. 89, Issue 11, p. 2875-2881
Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemodynamic instability
journal, June 2009
- Kurt, Mevlut; Oztas, Erkin; Kuran, Sedef
- The American Journal of Emergency Medicine, Vol. 27, Issue 5, p. 631.e1-631.e2
Arterial Uptake of Biodegradable Nanoparticles: Effect of Surface Modifications
journal, October 1998
- Labhasetwar, Vinod; Song, Cuxian; Humphrey, William
- Journal of Pharmaceutical Sciences, Vol. 87, Issue 10
Nanoindentation hardness, Young’s modulus, and creep behavior of organic–inorganic silica-based sol-gel thin films on copper
journal, September 2008
- Latella, Bruno A.; Gan, Bee K.; Barbé, Christophe J.
- Journal of Materials Research, Vol. 23, Issue 9
Rectal tacrolimus in the treatment of resistant ulcerative proctitis
journal, November 2008
- Lawrance, I. C.; Copeland, T. -S.
- Alimentary Pharmacology & Therapeutics, Vol. 28, Issue 10
Novel Therapy for Hearing Loss: Delivery of Insulin-Like Growth Factor 1 to the Cochlea Using Gelatin Hydrogel
journal, January 2007
- Lee, Kyu Yup; Nakagawa, Takayuki; Okano, Takayuki
- Otology & Neurotology, Vol. 28, Issue 7
Drug Treatment of Nonviral Sexually Transmitted Diseases: Specific Issues in Adolescents
journal, January 2001
- Lehmann, Corinne E.; Biro, Frank M.
- Paediatric Drugs, Vol. 3, Issue 7
Three-Dimensional Compositional Analysis of Drug Eluting Stent Coatings Using Cluster Secondary Ion Mass Spectrometry
journal, February 2008
- Mahoney, Christine M.; Fahey, Albert J.; Belu, Anna M.
- Analytical Chemistry, Vol. 80, Issue 3
Drug-Eluting Bioabsorbable Magnesium Stent
journal, December 2004
- Di Mario, Carlo; Griffiths, Huw; Goktekin, Omer
- Journal of Interventional Cardiology, Vol. 17, Issue 6
Revised NMR assignments for rapamycin.
journal, January 1991
- Mcalpine, James B.; Swanson, Susan J.; Jackson, Marianna
- The Journal of Antibiotics, Vol. 44, Issue 6
Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study
journal, September 2003
- Mehik, Aare; Alas, Peeter; Nickel, J. Curtis
- Urology, Vol. 62, Issue 3, p. 425-429
Treatment of Low-Grade Bulbar Transitional Cell Carcinoma with Urethral Instillation of Mitomycin C
journal, January 2008
- Melonakos, Emmanuel J.; Santucci, Richard A.
- Advances in Urology, Vol. 2008
Interactions of corneal cells with transforming growth factor β2-modified poly dimethyl siloxane surfaces
journal, January 2003
- Merrett, K.; Griffith, C. M.; Deslandes, Y.
- Journal of Biomedical Materials Research, Vol. 67A, Issue 3
Synthetic biodegradable polymers as orthopedic devices
journal, December 2000
- Middleton, John C.; Tipton, Arthur J.
- Biomaterials, Vol. 21, Issue 23, p. 2335-2346
Sizing up targets with nanoparticles
journal, January 2008
- Minchin, Rod
- Nature Nanotechnology, Vol. 3, Issue 1
Laryngotracheal Topicalization with Lidocaine Before Intubation Decreases the Incidence of Coughing on Emergence from General Anesthesia
journal, January 2004
- Minogue, Sean C.; Ralph, James; Lampa, Martin J.
- Anesthesia & Analgesia, Vol. 99, Issue 4
Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent
journal, April 2000
- Mishima, Kenji; Matsuyama, Kiyoshi; Tanabe, Daisaku
- AIChE Journal, Vol. 46, Issue 4, p. 857-865
Pharos neurovascular intracranial stent: Elective use for a symptomatic stenosis refractory to medical therapy
journal, October 2009
- Mocco, J.; Darkhabani, Ziad; Levy, Elad I.
- Catheterization and Cardiovascular Interventions, Vol. 74, Issue 4, p. 642-646
Prevalence of Tubo-Ovarian Abscess in Adolescents Diagnosed With Pelvic Inflammatory Disease in a Pediatric Emergency Department
journal, January 2006
- Mollen, Cynthia J.; Pletcher, Jonathan R.; Bellah, Richard D.
- Pediatric Emergency Care, Vol. 22, Issue 9
Post-ischemic brain damage: targeting PARP-1 within the ischemic neurovascular units as a realistic avenue to stroke treatment: PARP-1 and the ischemic neurovascular unit
journal, December 2008
- Moroni, Flavio; Chiarugi, Alberto
- FEBS Journal, Vol. 276, Issue 1
Magnetic Resonance Imaging Contrast Agent Targeted Toward Activated Platelets Allows In Vivo Detection of Thrombosis and Monitoring of Thrombolysis
journal, July 2008
- von zur Muhlen, C.; von Elverfeldt, D.; Moeller, J. A.
- Circulation, Vol. 118, Issue 3
Extracellular matrix binding mixed micelles for drug delivery applications
journal, July 2009
- O'Neil, Conlin P.; van der Vlies, André J.; Velluto, Diana
- Journal of Controlled Release, Vol. 137, Issue 2, p. 146-151
Salvage Intravesical Therapy with Interferon-α2b plus low dose Bacillus Calmette-Guerin is Effective in Patients with Superficial Bladder Cancer in whom Bacillus Calmette-Guerin Alone Previously Failed
journal, October 2001
- O’Donnell, Michael A.; Krohn, Janice; DeWOLF, William C.
- Journal of Urology, Vol. 166, Issue 4
Micellar Nanocarriers: Pharmaceutical Perspectives
journal, November 2006
- Torchilin, V. P.
- Pharmaceutical Research, Vol. 24, Issue 1
Tubers and tumors: rapamycin therapy for benign and malignant tumors
journal, April 2009
- Plas, David R.; Thomas, George
- Current Opinion in Cell Biology, Vol. 21, Issue 2, p. 230-236
Chronic Prostatitis/Chronic Pelvic Pain Syndrome in Elderly Men: Toward Better Understanding and Treatment
journal, January 2003
- Pontari, Michel A.
- Drugs & Aging, Vol. 20, Issue 15
Inflammation and anti-inflammatory therapy in chronic prostatitis
journal, December 2002
- Pontari, Michel
- Urology, Vol. 60, Issue 6, p. 29-33
Hydrogel Matrix Entrapping PLGA-Paclitaxel Microspheres: Drug Delivery with Near Zero-Order Release and Implantability Advantages for Malignant Brain Tumour Chemotherapy
journal, June 2009
- Ranganath, Sudhir Hulikal; Kee, Irene; Krantz, William B.
- Pharmaceutical Research, Vol. 26, Issue 9
Physical characterization of controlled release of paclitaxel from the TAXUS? Express2? drug-eluting stent
journal, January 2004
- Ranade, Shrirang V.; Miller, Kathleen M.; Richard, Robert E.
- Journal of Biomedical Materials Research, Vol. 71A, Issue 4
Inhibition of Apoptosis Through Localized Delivery of Rapamycin-Loaded Nanoparticles Prevented Neointimal Hyperplasia and Reendothelialized Injured Artery
journal, December 2008
- Reddy, Maram K.; Vasir, Jaspreet K.; Sahoo, Sanjeeb K.
- Circulation: Cardiovascular Interventions, Vol. 1, Issue 3
Sedation, Topical Pharyngeal Anesthesia and Cardiorespiratory Safety During Gastroscopy
journal, January 2006
- Ristikankare, Matti; Julkunen, Risto; Heikkinen, Markku
- Journal of Clinical Gastroenterology, Vol. 40, Issue 10
Crystal structure of human bone morphogenetic protein-2 at 2.7 Å resolution 1 1Edited by R. Huber
journal, March 1999
- Scheufler, Clemens; Sebald, Walter; Hülsmeyer, Martin
- Journal of Molecular Biology, Vol. 287, Issue 1
A comparison of the mechanical performance characteristics of seven drug-eluting stent systems
journal, February 2009
- Schmidt, W.; Lanzer, P.; Behrens, P.
- Catheterization and Cardiovascular Interventions, Vol. 73, Issue 3, p. 350-360
Trackability, Crossability, and Pushability of Coronary Stent Systems - an Experimental Approach
journal, January 2002
- Schmidt, W.; Grabow, N.; Behrens, P.
- Biomedizinische Technik/Biomedical Engineering, Vol. 47, Issue s1a
Topical Heparin: A Promising Agent for the Prevention of Tracheal Stenosis in Airway Surgery
journal, November 2009
- Sen, Serdar; Meteoglu, Ibrahim; Ogurlu, Mustafa
- Journal of Surgical Research, Vol. 157, Issue 1, p. e23-e29
Comparison of Coronary-Artery Bypass Surgery and Stenting for the Treatment of Multivessel Disease
journal, April 2001
- Serruys, Patrick W.; Unger, Felix; Sousa, J. Eduardo
- New England Journal of Medicine, Vol. 344, Issue 15
Hyaluronan and hyaluronidase in genitourinary tumors
journal, January 2008
- Simpson, Melanie, A.
- Frontiers in Bioscience, Vol. Volume, Issue 13
Mitomycin C and the endoscopic treatment of laryngotracheal stenosis: Are two applications better than one?
journal, February 2009
- Smith, Marshall E.; Elstad, Mark
- The Laryngoscope, Vol. 119, Issue 2
Controlled comparison between betamethasone gel and lidocaine jelly applied over tracheal tube to reduce postoperative sore throat, cough, and hoarseness of voice
journal, February 2008
- Sumathi, P. A.; Shenoy, T.; Ambareesha, M.
- British Journal of Anaesthesia, Vol. 100, Issue 2
Long-term Experience With Bacillus Calmette-Guerin Therapy of Upper Urinary Tract Transitional Cell Carcinoma in Patients Not Eligible for Surgery
journal, October 2002
- Thalmann, George N.; Markwalder, Regula; Walter, Bernhard
- The Journal of Urology, Vol. 168, Issue 4, p. 1381-1385
Poly(ethylene carbonate): A thermoelastic and biodegradable biomaterial for drug eluting stent coatings?
journal, February 2007
- Unger, F.; Westedt, U.; Hanefeld, P.
- Journal of Controlled Release, Vol. 117, Issue 3, p. 312-321
Effect of Surface Properties on Nanoparticle–Cell Interactions
journal, January 2010
- Verma, Ayush; Stellacci, Francesco
- Small, Vol. 6, Issue 1
A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study
journal, September 2009
- Wagenlehner, Florian M. E.; Schneider, Henning; Ludwig, Martin
- European Urology, Vol. 56, Issue 3, p. 544-551
Controlled release of sirolimus from a multilayered PLGA stent matrix
journal, November 2006
- Wang, Xintong; Venkatraman, Subbu S.; Boey, Freddy Y. C.
- Biomaterials, Vol. 27, Issue 32, p. 5588-5595
Treatment with melagatran alone or in combination with thrombolytic therapy reduced ischemic brain injury
journal, September 2008
- Wang, Chen Xu; Ding, Xiuqing; Shuaib, Ashfaq
- Experimental Neurology, Vol. 213, Issue 1, p. 171-175
Intravesical Pharmacotherapy for Non–Muscle-Invasive Bladder Cancer: A Critical Analysis of Currently Available Drugs, Treatment Schedules, and Long-Term Results
journal, January 2008
- Witjes, J. Alfred; Hendricksen, Kees
- European Urology, Vol. 53, Issue 1, p. 45-52
Biodegradation of poly(l-lactide-co-glycolide) tube stents in bile
journal, April 2008
- Xu, Xiaoyi; Liu, Tongjun; Zhang, Kai
- Polymer Degradation and Stability, Vol. 93, Issue 4, p. 811-817
Spray-As-You-Go Airway Topical Anesthesia in Patients with a Difficult Airway: A Randomized, Double-Blind Comparison of 2% and 4% Lidocaine
journal, January 2009
- Xue, Fu S.; Liu, He P.; He, Nong
- Anesthesia & Analgesia, Vol. 108, Issue 2
Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic
journal, January 2009
- Yepes, Manuel; Roussel, Benoit D.; Ali, Carine
- Trends in Neurosciences, Vol. 32, Issue 1, p. 48-55
Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
journal, January 2009
- Yousuf, Seema; Atif, Fahim; Ahmad, Muzamil
- Brain Research, Vol. 1250, p. 242-253
Synthesis and characterization of biodegradable low molecular weight aliphatic polyesters and their use in protein-delivery systems
journal, January 2003
- Zhou, Shaobing; Deng, Xianmo; Li, Xiaohong
- Journal of Applied Polymer Science, Vol. 91, Issue 3, p. 1848-1856
Influence of metal alloy and the profile of coronary stents in patients with multivessel coronary disease
journal, January 2011
- Abreu Filho, Luciano Maurício de; Forte, Antonio Artur da Cruz; Sumita, Marcos Kiyoshi
- Clinics, Vol. 66, Issue 6
Three-Dimensional Compositional Analysis of Drug Eluting Stent Coatings Using Cluster Secondary Ion Mass Spectrometry
journal, February 2008
- Mahoney, Christine M.; Fahey, Albert J.; Belu, Anna M.
- Analytical Chemistry, Vol. 80, Issue 3
The influence of carbon fibres on the resorption time and mechanical properties of the lactide–glycolide co-polymer
journal, January 2007
- Chłopek, Jan; Morawska-Chochół, Anna; Bajor, Grzegorz
- Journal of Biomaterials Science, Polymer Edition, Vol. 18, Issue 11
Sintering Technique for the Preparation of Polymer Matrices for the Controlled Release of Macromolecules
journal, August 1984
- Cohen, Jonathan; Siegel, Ronald A.; Langerx, Robert
- Journal of Pharmaceutical Sciences, Vol. 73, Issue 8
Selection of coronary stents
journal, September 2002
- Colombo, Antonio; Stankovic, Goran; Moses, Jeffrey W.
- Journal of the American College of Cardiology, Vol. 40, Issue 6, p. 1021-1033
A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies
journal, November 2009
- Koh, Li Buay; Rodriguez, Isabel; Venkatraman, Subbu S.
- Acta Biomaterialia, Vol. 5, Issue 9, p. 3411-3422
Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography
journal, April 2007
- Matsumoto, D.; Shite, J.; Shinke, T.
- European Heart Journal, Vol. 28, Issue 8
Crystallization processes in pharmaceutical technology and drug delivery design
journal, April 2000
- Shekunov, B. Yu.; York, P.
- Journal of Crystal Growth, Vol. 211, Issue 1-4, p. 122-136
Study on the preparation and characterization of biodegradable polylactide/multi-walled carbon nanotubes nanocomposites
journal, July 2007
- Wu, Chin-San; Liao, Hsin-Tzu
- Polymer, Vol. 48, Issue 15, p. 4449-4458
Drug-Eluting Bioresorbable Stents for Various Applications
journal, August 2006
- Zilberman, Meital; Eberhart, Robert C.
- Annual Review of Biomedical Engineering, Vol. 8, Issue 1