Medical implants and methods of making medical implants

Title: Medical implants and methods of making medical implants

A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.

Inventors:: Shaw, Wendy J; Yonker, Clement R; Fulton, John L; Tarasevich, Barbara J; McClain, James B; Taylor, Doug

Issue Date:: 2014-09-16

OSTI Identifier:: 1159830

Assignee:: Battelle Memorial Institute (Richland, WA) PNNL

Patent Number(s):: 8,834,913

Application Number:: 12/648,106

Contract Number:: AC06-76RLO1830

Research Org:: Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 42 ENGINEERING

Full Text
View Full Text

Have feedback or suggestions for a way to improve these results? !

Save / Share this Record no
Export Metadata
- Endnote
- RIS
- Excel
- CSV
- XML
Send to Email

Send to Email

Email address:

Content:

Works referenced in this record:

Supercritical fluid molecular spray thin films and fine powders
patent, March 1988

Smith, Richard
US Patent Document 4,734,451
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F4734451

Stents with hybrid coating for medical devices
patent, May 2001

Zhong, Sheng-ping
US Patent Document 6,231,600
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6231600

Implant coating for control of tissue/implant interactions
patent, December 2002

Moussy, Francis; Kreutzer, Donald; Burgess, Diane
US Patent Document 6,497,729
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F6497729

Prodrug research: futile or fertile?
journal, December 2004

Testa, Bernard
Biochemical Pharmacology, Vol. 68, Issue 11, p. 2097-2106
DOI: 10.1016/j.bcp.2004.07.005

Immobilization of heparin on a silicone surface through a heterobifunctional PEG spacer
journal, December 2005

Chen, Hong; Chen, Yang; Sheardown, Heather
Biomaterials, Vol. 26, Issue 35, p. 7418-7424
DOI: 10.1016/j.biomaterials.2005.05.053

Antibiotics for preventing recurrent urinary tract infection in non-pregnant women
journal, July 2004

Albert, Xavier; Huertas, Isabel; Pereiro, Inmaculado
Cochrane Database of Systematic Reviews
DOI: 10.1002/14651858.CD001209.pub2

Chemical imaging of drug eluting coatings: Combining surface analysis and confocal Raman microscopy
journal, March 2008

Belu, Anna; Mahoney, Christine; Wormuth, Klaus
Journal of Controlled Release, Vol. 126, Issue 2, p. 111-121
DOI: 10.1016/j.jconrel.2007.11.015

A recombinant human enzyme for enhanced interstitial transport of therapeutics
journal, August 2006

Bookbinder, L. H.; Hofer, A.; Haller, M. F.
Journal of Controlled Release, Vol. 114, Issue 2, p. 230-241
DOI: 10.1016/j.jconrel.2006.05.027

Precipitation of ultrafine organic crystals from the rapid expansion of supercritical solutions over a capillary and a frit nozzle
journal, April 1997

Domingo, Concepción; Berends, Edwin; van Rosmalen, Gerda Maria
The Journal of Supercritical Fluids, Vol. 10, Issue 1, p. 39-55
DOI: 10.1016/S0896-8446(97)00011-9

Conscious sedation for gastroscopy: Patient tolerance and cardiorespiratory parameters
journal, March 1995

Froehlich, Florian; Schwizer, Werner; Thorens, Joël
Gastroenterology, Vol. 108, Issue 3, p. 697-704
DOI: 10.1016/0016-5085(95)90441-7

Thin fluoropolymer films and nanoparticle coatings from the rapid expansion of supercritical carbon dioxide solutions with electrostatic collection
journal, June 2003

Fulton, John L.; Deverman, George S.; Yonker, Clement R.
Polymer, Vol. 44, Issue 13, p. 3627-3632
DOI: 10.1016/S0032-3861(03)00280-5

Differential Effects of Drug-Eluting Stents on Local Endothelium-Dependent Coronary Vasomotion
journal, June 2008

Hamilos, Michalis I.; Ostojic, Miodrag; Beleslin, Branko
Journal of the American College of Cardiology, Vol. 51, Issue 22, p. 2123-2129
DOI: 10.1016/j.jacc.2007.12.059

Tubo-ovarian Abscess in Virginal Adolescents: Exposure of the Underlying Etiology
journal, June 2009

Hartmann, K. A.; Lerand, S. J.; Jay, M. S.
Journal of Pediatric and Adolescent Gynecology, Vol. 22, Issue 3, p. e13-e16
DOI: 10.1016/j.jpag.2008.03.006

Nylon 6/Na–montmorillonite nanocomposites prepared by compounding Nylon 6 with Na–montmorillonite slurry
journal, May 2003

Hasegawa, Naoki; Okamoto, Hirotaka; Kato, Makoto
Polymer, Vol. 44, Issue 10, p. 2933-2937
DOI: 10.1016/S0032-3861(03)00215-5

Characterization of perivascular poly(lactic-co-glycolic acid) films containing paclitaxel
journal, September 2004

Jackson, John K.; Smith, Janet; Letchford, Kevin
International Journal of Pharmaceutics, Vol. 283, Issue 1-2, p. 97-109
DOI: 10.1016/j.ijpharm.2004.06.025

Cyclic acetals of 4,1′,6′-trichloro-4,1′,6′-trideoxy-galacto-sucrose and their conversion into methyl ether derivatives
journal, May 1990

Khan, Riaz; Patel, Gita
Carbohydrate Research, Vol. 198, Issue 2, p. 275-283
DOI: 10.1016/0008-6215(90)84298-9

Enzymic regioselective hydrolysis of peracetylated reducing disaccharides, specifically at the anomeric centre: Intermediates for the synthesis of oligosaccharides.
journal, November 1993

Khan, Riaz; Gropen, Line; Konowicz, Paul A.
Tetrahedron Letters, Vol. 34, Issue 48, p. 7767-7770
DOI: 10.1016/S0040-4039(00)61561-7

Adhesion and permeability of polyimide-clay nanocomposite films for protective coatings
journal, June 2003

Khayankarn, Orasa; Magaraphan, Rathanawan; Schwank, Johannes W.
Journal of Applied Polymer Science, Vol. 89, Issue 11, p. 2875-2881
DOI: 10.1002/app.12326

Tandem oral, rectal, and nasal administrations of Ankaferd Blood Stopper to control profuse bleeding leading to hemodynamic instability
journal, June 2009

Kurt, Mevlut; Oztas, Erkin; Kuran, Sedef
The American Journal of Emergency Medicine, Vol. 27, Issue 5, p. 631.e1-631.e2
DOI: 10.1016/j.ajem.2008.09.003

Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study
journal, September 2003

Mehik, Aare; Alas, Peeter; Nickel, J. Curtis
Urology, Vol. 62, Issue 3, p. 425-429
DOI: 10.1016/S0090-4295(03)00466-7

Synthetic biodegradable polymers as orthopedic devices
journal, December 2000

Middleton, John C.; Tipton, Arthur J.
Biomaterials, Vol. 21, Issue 23, p. 2335-2346
DOI: 10.1016/S0142-9612(00)00101-0

Microencapsulation of proteins by rapid expansion of supercritical solution with a nonsolvent
journal, April 2000

Mishima, Kenji; Matsuyama, Kiyoshi; Tanabe, Daisaku
AIChE Journal, Vol. 46, Issue 4, p. 857-865
DOI: 10.1002/aic.690460418

Pharos neurovascular intracranial stent: Elective use for a symptomatic stenosis refractory to medical therapy
journal, October 2009

Mocco, J.; Darkhabani, Ziad; Levy, Elad I.
Catheterization and Cardiovascular Interventions, Vol. 74, Issue 4, p. 642-646
DOI: 10.1002/ccd.22054

Extracellular matrix binding mixed micelles for drug delivery applications
journal, July 2009

O'Neil, Conlin P.; van der Vlies, André J.; Velluto, Diana
Journal of Controlled Release, Vol. 137, Issue 2, p. 146-151
DOI: 10.1016/j.jconrel.2009.03.013

Tubers and tumors: rapamycin therapy for benign and malignant tumors
journal, April 2009

Plas, David R.; Thomas, George
Current Opinion in Cell Biology, Vol. 21, Issue 2, p. 230-236
DOI: 10.1016/j.ceb.2008.12.013

Inflammation and anti-inflammatory therapy in chronic prostatitis
journal, December 2002

Pontari, Michel
Urology, Vol. 60, Issue 6, p. 29-33
DOI: 10.1016/S0090-4295(02)02381-6

A comparison of the mechanical performance characteristics of seven drug-eluting stent systems
journal, February 2009

Schmidt, W.; Lanzer, P.; Behrens, P.
Catheterization and Cardiovascular Interventions, Vol. 73, Issue 3, p. 350-360
DOI: 10.1002/ccd.21832

Topical Heparin: A Promising Agent for the Prevention of Tracheal Stenosis in Airway Surgery
journal, November 2009

Sen, Serdar; Meteoglu, Ibrahim; Ogurlu, Mustafa
Journal of Surgical Research, Vol. 157, Issue 1, p. e23-e29
DOI: 10.1016/j.jss.2009.01.028

Long-term Experience With Bacillus Calmette-Guerin Therapy of Upper Urinary Tract Transitional Cell Carcinoma in Patients Not Eligible for Surgery
journal, October 2002

Thalmann, George N.; Markwalder, Regula; Walter, Bernhard
The Journal of Urology, Vol. 168, Issue 4, p. 1381-1385
DOI: 10.1016/S0022-5347(05)64454-0

Poly(ethylene carbonate): A thermoelastic and biodegradable biomaterial for drug eluting stent coatings?
journal, February 2007

Unger, F.; Westedt, U.; Hanefeld, P.
Journal of Controlled Release, Vol. 117, Issue 3, p. 312-321
DOI: 10.1016/j.jconrel.2006.11.003

A Pollen Extract (Cernilton) in Patients with Inflammatory Chronic Prostatitis–Chronic Pelvic Pain Syndrome: A Multicentre, Randomised, Prospective, Double-Blind, Placebo-Controlled Phase 3 Study
journal, September 2009

Wagenlehner, Florian M. E.; Schneider, Henning; Ludwig, Martin
European Urology, Vol. 56, Issue 3, p. 544-551
DOI: 10.1016/j.eururo.2009.05.046

Controlled release of sirolimus from a multilayered PLGA stent matrix
journal, November 2006

Wang, Xintong; Venkatraman, Subbu S.; Boey, Freddy Y. C.
Biomaterials, Vol. 27, Issue 32, p. 5588-5595
DOI: 10.1016/j.biomaterials.2006.07.016

Treatment with melagatran alone or in combination with thrombolytic therapy reduced ischemic brain injury
journal, September 2008

Wang, Chen Xu; Ding, Xiuqing; Shuaib, Ashfaq
Experimental Neurology, Vol. 213, Issue 1, p. 171-175
DOI: 10.1016/j.expneurol.2008.05.020

Intravesical Pharmacotherapy for Non–Muscle-Invasive Bladder Cancer: A Critical Analysis of Currently Available Drugs, Treatment Schedules, and Long-Term Results
journal, January 2008

Witjes, J. Alfred; Hendricksen, Kees
European Urology, Vol. 53, Issue 1, p. 45-52
DOI: 10.1016/j.eururo.2007.08.015

Biodegradation of poly(l-lactide-co-glycolide) tube stents in bile
journal, April 2008

Xu, Xiaoyi; Liu, Tongjun; Zhang, Kai
Polymer Degradation and Stability, Vol. 93, Issue 4, p. 811-817
DOI: 10.1016/j.polymdegradstab.2008.01.022

Tissue-type plasminogen activator in the ischemic brain: more than a thrombolytic
journal, January 2009

Yepes, Manuel; Roussel, Benoit D.; Ali, Carine
Trends in Neurosciences, Vol. 32, Issue 1, p. 48-55
DOI: 10.1016/j.tins.2008.09.006

Resveratrol exerts its neuroprotective effect by modulating mitochondrial dysfunctions and associated cell death during cerebral ischemia
journal, January 2009

Yousuf, Seema; Atif, Fahim; Ahmad, Muzamil
Brain Research, Vol. 1250, p. 242-253
DOI: 10.1016/j.brainres.2008.10.068

Synthesis and characterization of biodegradable low molecular weight aliphatic polyesters and their use in protein-delivery systems
journal, January 2003

Zhou, Shaobing; Deng, Xianmo; Li, Xiaohong
Journal of Applied Polymer Science, Vol. 91, Issue 3, p. 1848-1856
DOI: 10.1002/app.13385

Selection of coronary stents
journal, September 2002

Colombo, Antonio; Stankovic, Goran; Moses, Jeffrey W.
Journal of the American College of Cardiology, Vol. 40, Issue 6, p. 1021-1033
DOI: 10.1016/S0735-1097(02)02123-X

A novel nanostructured poly(lactic-co-glycolic-acid)–multi-walled carbon nanotube composite for blood-contacting applications: Thrombogenicity studies
journal, November 2009

Koh, Li Buay; Rodriguez, Isabel; Venkatraman, Subbu S.
Acta Biomaterialia, Vol. 5, Issue 9, p. 3411-3422
DOI: 10.1016/j.actbio.2009.06.003

Crystallization processes in pharmaceutical technology and drug delivery design
journal, April 2000

Shekunov, B. Yu.; York, P.
Journal of Crystal Growth, Vol. 211, Issue 1-4, p. 122-136
DOI: 10.1016/S0022-0248(99)00819-2

Study on the preparation and characterization of biodegradable polylactide/multi-walled carbon nanotubes nanocomposites
journal, July 2007

Wu, Chin-San; Liao, Hsin-Tzu
Polymer, Vol. 48, Issue 15, p. 4449-4458
DOI: 10.1016/j.polymer.2007.06.004

Similar Records

Similar records in DOepatents and OSTI.GOV collections:

Biocompatible implants and methods of making and attaching the same

Patent Rowley, Adrian P ; Laude, Lucien D ; Humayun, Mark S ; Weiland, James D ; Lotfi, Atoosa ; Markland, Jr., Francis S

The invention provides a biocompatible silicone implant that can be securely affixed to living tissue through interaction with integral membrane proteins (integrins). A silicone article containing a laser-activated surface is utilized to make the implant. One example is an implantable prosthesis to treat blindness caused by outer retinal degenerative diseases. The device bypasses damaged photoreceptors and electrically stimulates the undamaged neurons of the retina. Electrical stimulation is achieved using a silicone microelectrode array (MEA). A safe, protein adhesive is used in attaching the MEA to the retinal surface and assist in alleviating focal pressure effects. Methods of making and attachingmore » such implants are also provided.« less
Full Text Available October 2014
Ultrafine-grained titanium for medical implants

Patent Zhu, Yuntian T. ; Lowe, Terry C. ; Valiev, Ruslan Z. ; Stolyarov, Vladimir V. ; Latysh, Vladimir V. ; Raab, Georgy J.

We disclose ultrafine-grained titanium. A coarse-grained titanium billet is subjected to multiple extrusions through a preheated equal channel angular extrusion (ECAE) die, with billet rotation between subsequent extrusions. The resulting billet is cold processed by cold rolling and/or cold extrusion, with optional annealing. The resulting ultrafine-grained titanium has greatly improved mechanical properties and is used to make medical implants.
Full Text Available January 2002
Ion binding compounds, radionuclide complexes, methods of making radionuclide complexes, methods of extracting radionuclides, and methods of delivering radionuclides to target locations

Patent Chen, Xiaoyuan ; Wai, Chien M. ; Fisher, Darrell R.

The invention pertains to compounds for binding lanthanide ions and actinide ions. The invention further pertains to compounds for binding radionuclides, and to methods of making radionuclide complexes. Also, the invention pertains to methods of extracting radionuclides. Additionally, the invention pertains to methods of delivering radionuclides to target locations. In one aspect, the invention includes a compound comprising: a) a calix[n]arene group, wherein n is an integer greater than 3, the calix[n]arene group comprising an upper rim and a lower rim; b) at least one ionizable group attached to the lower rim; and c) an ion selected from the groupmore »« less
Full Text Available January 2000
Textured catalysts, methods of making textured catalysts, and methods of catalyzing reactions conducted in hydrothermal conditions

Patent Werpy, Todd ; Wang, Yong

A textured catalyst having a hydrothermally-stable support, a metal oxide and a catalyst component is described. Methods of conducting aqueous phase reactions that are catalyzed by a textured catalyst are also described. The invention also provides methods of making textured catalysts and methods of making chemical products using a textured catalyst.
Full Text Available December 2003
Structures for capturing CO.sub.2, methods of making the structures, and methods of capturing CO.sub.2

Patent Jones, Christopher W ; Hicks, Jason C ; Fauth, Daniel J ; McMahan, Gray

Briefly described, embodiments of this disclosure, among others, include carbon dioxide (CO.sub.2) sorption structures, methods of making CO.sub.2 sorption structures, and methods of using CO.sub.2 sorption structures.
Full Text Available October 2012