Medical implants and methods of making medical implants
Abstract
A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.
- Inventors:
- Issue Date:
- Research Org.:
- Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1159830
- Patent Number(s):
- 8834913
- Application Number:
- 12/648,106
- Assignee:
- Battelle Memorial Institute (Richland, WA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61L - METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL
- DOE Contract Number:
- AC06-76RL01830
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 42 ENGINEERING
Citation Formats
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, and Taylor, Doug. Medical implants and methods of making medical implants. United States: N. p., 2014.
Web.
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, & Taylor, Doug. Medical implants and methods of making medical implants. United States.
Shaw, Wendy J, Yonker, Clement R, Fulton, John L, Tarasevich, Barbara J, McClain, James B, and Taylor, Doug. Tue .
"Medical implants and methods of making medical implants". United States. https://www.osti.gov/servlets/purl/1159830.
@article{osti_1159830,
title = {Medical implants and methods of making medical implants},
author = {Shaw, Wendy J and Yonker, Clement R and Fulton, John L and Tarasevich, Barbara J and McClain, James B and Taylor, Doug},
abstractNote = {A medical implant device having a substrate with an oxidized surface and a silane derivative coating covalently bonded to the oxidized surface. A bioactive agent is covalently bonded to the silane derivative coating. An implantable stent device including a stent core having an oxidized surface with a layer of silane derivative covalently bonded thereto. A spacer layer comprising polyethylene glycol (PEG) is covalently bonded to the layer of silane derivative and a protein is covalently bonded to the PEG. A method of making a medical implant device including providing a substrate having a surface, oxidizing the surface and reacting with derivitized silane to form a silane coating covalently bonded to the surface. A bioactive agent is then covalently bonded to the silane coating. In particular instances, an additional coating of bio-absorbable polymer and/or pharmaceutical agent is deposited over the bioactive agent.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue Sep 16 00:00:00 EDT 2014},
month = {Tue Sep 16 00:00:00 EDT 2014}
}
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