DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Plume collimation for laser ablation electrospray ionization mass spectrometry

Abstract

In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.

Inventors:
;
Issue Date:
Research Org.:
George Washington Univ., Washington, DC (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1157080
Patent Number(s):
8829426
Application Number:
13/549,988
Assignee:
The George Washington University (Washington, DC)
Patent Classifications (CPCs):
H - ELECTRICITY H01 - BASIC ELECTRIC ELEMENTS H01J - ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
DOE Contract Number:  
FG02-01ER15129
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Vertes, Akos, and Stolee, Jessica A. Plume collimation for laser ablation electrospray ionization mass spectrometry. United States: N. p., 2014. Web.
Vertes, Akos, & Stolee, Jessica A. Plume collimation for laser ablation electrospray ionization mass spectrometry. United States.
Vertes, Akos, and Stolee, Jessica A. Tue . "Plume collimation for laser ablation electrospray ionization mass spectrometry". United States. https://www.osti.gov/servlets/purl/1157080.
@article{osti_1157080,
title = {Plume collimation for laser ablation electrospray ionization mass spectrometry},
author = {Vertes, Akos and Stolee, Jessica A.},
abstractNote = {In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {9}
}

Works referenced in this record:

Frequency standard using an atomic fountain of optically trapped atoms
patent, August 1994


Atmospheric pressure matrix assisted laser desorption
patent, October 1999


Methods and apparatus for cell analysis
patent, March 2003


Mass spectrometric methods for biomolecular screening
patent, December 2003


Method and apparatus for feedback controlled electrospray
patent, June 2004


Atmospheric pressure ion source
patent, September 2005


Solid phase sequencing of double-stranded nucleic acids
patent, January 2006


Method for predicting cardiovascular events
patent, July 2006


Apparatus and method for sensor control and feedback
patent, August 2006


Method for atmospheric pressure analyte ionization
patent, September 2006


MALDI-IM-ortho-TOF mass spectrometry with simultaneous positive and negative mode detection
patent, January 2007


Diagnosis of Smith-Lemli-Optiz syndrome
patent, March 2007


Combined chemical/biological agent detection system and method utilizing mass spectrometry
patent, September 2007


Method and system for desorption electrospray ionization
patent, February 2008


Pattern recognition of whole cell mass spectra
patent, March 2010


Mass spectroscopic reaction-monitoring method
patent, May 2010


Protein microscope
patent, June 2010


Peptide sequencing from peptide fragmentation mass spectra
patent, August 2010


Method and apparatus for feedback controlled electrospray
patent-application, December 2002


Size separation of analytes using monomeric surfactants
patent-application, January 2003


Method for searching for gene encoding nuclear transport protein
patent-application, September 2003


Method and device for manipulating microscopic quantities of material
patent-application, March 2004


Method and compositions for identifying anti-HIV therapeutic compounds
patent-application, June 2004


Methods and apparatuses for analyzing biological samples by mass spectrometry
patent-application, February 2005


Gold implantation/deposition of biological samples for laser desorption three dimensional depth profiling of tissues
patent-application, February 2005


Method and apparatus for mass spectrometry analysis of aerosol particles at atmospheric pressure
patent-application, February 2005


Laser desorption ion source
patent-application, March 2005


Pattern recognition of whole cell mass spectra
patent-application, March 2005


Method and system for desorption electrospray ionization
patent-application, October 2005


Combined chemical/biological agent detection system and method utilizing mass spectrometry
patent-application, November 2005


Methods for isolating molecular mimetics of unique Neisseria meningitidis serogroup B epitopes
patent-application, February 2006


Differential diagnosis of vitamin B12, vitamin B6, and folic acid disorders
patent-application, May 2006


Peptide sequencing from peptide fragmentation mass spectra
patent-application, August 2006


Computational method and system for mass spectral analysis
patent-application, September 2006


Systems and methods for characterization of molecules
patent-application, November 2006


Mass spectrometric based method for sample identification
patent-application, December 2006


Methods for direct biomolecule identification by matrix-assisted laser desorption ionization (MALDI) mass spectrometry
patent-application, May 2007


Method of Analyzing Biosample by Laser Ablation and Apparatus Therefor
patent-application, January 2008


Hypolipidemic and/or hypocholesteremic compounds obtainable from the goldenseal plant
patent-application, May 2008


Mass Spectrometry With Laser Ablation
patent-application, June 2008


Protein Microscope
patent-application, June 2008


Rare Cell Analysis Using Sample Splitting and DNA Tags
patent-application, September 2008


Laser desorption - electrospray ion (ESI) source for mass spectrometers
patent-application, November 2008


Lamp
patent-application, January 2009


Method for Analyzing Foods
patent-application, February 2009


Imaging Mass Spectrometry Principle and Its Application in a Device
patent-application, October 2009


Laser ablation flowing atmospheric-pressure afterglow for ambient mass spectrometry
patent-application, November 2009


Microfluidic Devices and Production Methods Therefor
patent-application, April 2010


Gold Implantation/Deposition of Biological Samples for Laser Desorption Two and Three Dimensional Depth Profiling of Biological Tissues
patent-application, April 2010


Ionization Device
patent-application, April 2010


Methods for Detecting Metabolic States by Laser Ablation Electrospray Ionization Mass Spectrometry
patent-application, November 2010


Method and apparatus for identification of biological material
patent-application, August 2011


Subcellular Analysis by Laser Ablation Electrospray Ionization Mass Spectrometry
patent-application, September 2011


Vaporization Device and Method for Imaging Mass Spectrometry
patent-application, June 2012


Laser spray: electric field-assisted matrix-assisted laser desorption/ionization
journal, April 2004


In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry
journal, October 2009


Intact and top-down characterization of biomolecules and direct analysis using infrared matrix-assisted laser desorption electrospray ionization coupled to FT-ICR mass spectrometry
journal, April 2009


Nanoscale Atmospheric Pressure Laser Ablation-Mass Spectrometry
journal, April 2001


New dimension in nano-imaging: breaking through the diffraction limit with scanning near-field optical microscopy
journal, November 2004


Direct Protein Detection from Biological Media through Electrospray-Assisted Laser Desorption Ionization/Mass Spectrometry
journal, May 2006


Versatile New Ion Source for the Analysis of Materials in Open Air under Ambient Conditions
journal, April 2005


Laser Ablation Electrospray Ionization for Atmospheric Pressure, in Vivo, and Imaging Mass Spectrometry
journal, November 2007


Recent Advances in Optical Tweezers
journal, June 2008


In Situ Metabolic Profiling of Single Cells by Laser Ablation Electrospray Ionization Mass Spectrometry
journal, October 2009


Infrared laser-assisted desorption electrospray ionization mass spectrometry
journal, January 2008


Ablation and analysis of small cell populations and single cells by consecutive laser pulses
journal, June 2010


Infrared Laser Ablation Atmospheric Pressure Photoionization Mass Spectrometry
journal, January 2012


Elevated subcortical choline metabolites in cognitively and clinically asymptomatic HIV patients
journal, March 1999


    Works referencing / citing this record:

    Fluidic channel based on a filtered, free-space electromagnetic wave source
    patent, April 2016