Global to push GA events into
skip to main content

Title: Methods and systems for Raman and optical cross-interrogation in flow-through silicon membranes

Cross-interrogating photonic detection systems and methods are shown. A flow through photonic crystal membrane with a surface enhanced Raman scattering (SERS) substrate is provided with pores which are distributed along multiple regions. The pores of one region have walls to which a first type of target specific anchor can be attached, while pores of another region have walls to which a second type of target specific anchor can be attached. An optical arrangement out-of-plane to the SERS substrate is also provided for enhanced sensitivity and identification of target organisms.
Inventors:
;
Issue Date:
OSTI Identifier:
1156954
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) LLNL
Patent Number(s):
8,830,450
Application Number:
12/958,302
Contract Number:
AC52-07NA27344
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Works referenced in this record:

Self-referenced assay method for photonic crystal biosensors: Application to small molecule analytes
journal, January 2007
  • Chan, Leo L.; Cunningham, Brian T.; Li, Peter Y.
  • Sensors and Actuators B: Chemical, Vol. 120, Issue 2, p. 392-398
  • DOI: 10.1016/j.snb.2006.02.047

Enzyme Immobilization on Porous Silicon Surfaces
journal, February 2004
  • Létant, S. E.; Hart, B. R.; Kane, S. R.
  • Advanced Materials, Vol. 16, Issue 8, p. 689-693
  • DOI: 10.1002/adma.200306173

Functionalized silicon membranes for selective bio-organism capture
journal, April 2003
  • Létant, Sonia E.; Hart, Bradley R.; van Buuren, Anthony W.
  • Nature Materials, Vol. 2, Issue 6, p. 391-395
  • DOI: 10.1038/nmat888

Photonic crystal laser sources for chemical detection
journal, June 2003
  • Lončar, Marko; Scherer, Axel; Qiu, Yueming
  • Applied Physics Letters, Vol. 82, Issue 26, p. 4648-4650
  • DOI: 10.1063/1.1586781

Immobilization of antibodies in micropatterns for cell detection by optical diffraction
journal, November 2000

Localized Functionalization of Single Nanopores
journal, February 2006
  • Nilsson, J.; Lee, J. R. I.; Ratto, T. V.
  • Advanced Materials, Vol. 18, Issue 4, p. 427-431
  • DOI: 10.1002/adma.200501991

Integration of porous silicon chips in an electronic artificial nose
journal, September 2000
  • Létant, S. E.; Content, S.; Tan, Tze Tsung
  • Sensors and Actuators B: Chemical, Vol. 69, Issue 1-2, p. 193-198
  • DOI: 10.1016/S0925-4005(00)00539-6

New biochip technology for label-free detection of pathogens and their toxins
journal, May 2003
  • Grow, Ann E.; Wood, Laurie L.; Claycomb, Johanna L.
  • Journal of Microbiological Methods, Vol. 53, Issue 2, p. 221-233
  • DOI: 10.1016/S0167-7012(03)00026-5

Single virus detection from the reactive shift of a whispering-gallery mode
journal, December 2008
  • Vollmer, F.; Arnold, S.; Keng, D.
  • Proceedings of the National Academy of Sciences, Vol. 105, Issue 52, p. 20701-20704
  • DOI: 10.1073/pnas.0808988106

National validation study of a swab protocol for the recovery of Bacillus anthracis spores from surfaces
journal, May 2010
  • Hodges, Lisa R.; Rose, Laura J.; O'Connell, Heather
  • Journal of Microbiological Methods, Vol. 81, Issue 2, p. 141-146
  • DOI: 10.1016/j.mimet.2010.02.010

Cryo-electron tomography of vaccinia virus
journal, February 2005
  • Cyrklaff, M.; Risco, C.; Fernandez, J. J.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 8, p. 2772-2777
  • DOI: 10.1073/pnas.0409825102

Towards on-site pathogen detection using antibody-based sensors
journal, November 2008
  • Skottrup, Peter Durand; Nicolaisen, Mogens; Justesen, Annemarie Fejer
  • Biosensors and Bioelectronics, Vol. 24, Issue 3, p. 339-348
  • DOI: 10.1016/j.bios.2008.06.045

Most-Probable-Number Rapid Viability PCR method to detect viable spores of Bacillus anthracis in swab samples
journal, May 2010
  • Létant, S. E.; Kane, S. R.; Murphy, G. A.
  • Journal of Microbiological Methods, Vol. 81, Issue 2, p. 200-202
  • DOI: 10.1016/j.mimet.2010.02.011

Rapid, high-throughput, culture-based PCR methods to analyze samples for viable spores of Bacillus anthracis and its surrogates
journal, March 2009
  • Kane, S. R.; Létant, S. E.; Murphy, G. A.
  • Journal of Microbiological Methods, Vol. 76, Issue 3, p. 278-284
  • DOI: 10.1016/j.mimet.2008.12.005

Multilayer silver nanoparticles-modified optical fiber tip for high performance SERS remote sensing
journal, June 2010
  • Andrade, Gustavo F. S.; Fan, MeiKun; Brolo, Alexandre G.
  • Biosensors and Bioelectronics, Vol. 25, Issue 10, p. 2270-2275
  • DOI: 10.1016/j.bios.2010.03.007

Selective Colorimetric Detection of Polynucleotides Based on the Distance-Dependent Optical Properties of Gold Nanoparticles
journal, August 1997

Surface Plasmon Resonance Scattering and Absorption of anti-EGFR Antibody Conjugated Gold Nanoparticles in Cancer Diagnostics: Applications in Oral Cancer
journal, May 2005
  • El-Sayed, Ivan H.; Huang, Xiaohua; El-Sayed, Mostafa A.
  • Nano Letters, Vol. 5, Issue 5, p. 829-834
  • DOI: 10.1021/nl050074e

Raman spectra of pyridine adsorbed at a silver electrode
journal, May 1974

A Nanoscale Optical Biosensor:  Sensitivity and Selectivity of an Approach Based on the Localized Surface Plasmon Resonance Spectroscopy of Triangular Silver Nanoparticles
journal, September 2002
  • Haes, Amanda J.; Van Duyne, Richard P.
  • Journal of the American Chemical Society, Vol. 124, Issue 35, p. 10596-10604
  • DOI: 10.1021/ja020393x

A Localized Surface Plasmon Resonance Biosensor: First Steps toward an Assay for Alzheimer's Disease
journal, June 2004
  • Haes, Amanda J.; Hall, W. Paige; Chang, Lei
  • Nano Letters, Vol. 4, Issue 6, p. 1029-1034
  • DOI: 10.1021/nl049670j

Nanostructured model biomaterial surfaces prepared by colloidal lithography
journal, January 1999

Exploitation of Localized Surface Plasmon Resonance
journal, October 2004

Single Molecule Detection Using Surface-Enhanced Raman Scattering (SERS)
journal, March 1997

Nanoimprinted optical fibres: Biotemplated nanostructures for SERS sensing
journal, January 2009
  • Kostovski, G.; White, D. J.; Mitchell, A.
  • Biosensors and Bioelectronics, Vol. 24, Issue 5, p. 1531-1535
  • DOI: 10.1016/j.bios.2008.10.016

Chain Length Dependence and Sensing Capabilities of the Localized Surface Plasmon Resonance of Silver Nanoparticles Chemically Modified with Alkanethiol Self-Assembled Monolayers
journal, February 2001
  • Malinsky, Michelle Duval; Kelly, K. Lance; Schatz, George C.
  • Journal of the American Chemical Society, Vol. 123, Issue 7, p. 1471-1482
  • DOI: 10.1021/ja003312a

Probing Single Molecules and Single Nanoparticles by Surface-Enhanced Raman Scattering
journal, February 1997

Optical characterization of electronic transitions arising from the Au/S interface of self-assembled n-alkanethiolate monolayers
journal, November 1995

Fabrication of Crescent-Shaped Optical Antennas
journal, September 2005
  • Shumaker-Parry, J. S.; Rochholz, H.; Kreiter, M.
  • Advanced Materials, Vol. 17, Issue 17, p. 2131-2134
  • DOI: 10.1002/adma.200500063

Langmuir−Blodgett Silver Nanowire Monolayers for Molecular Sensing Using Surface-Enhanced Raman Spectroscopy
journal, September 2003
  • Tao, Andrea; Kim, Franklin; Hess, Christian
  • Nano Letters, Vol. 3, Issue 9, p. 1229-1233
  • DOI: 10.1021/nl0344209

Single-fibre surface-enhanced Raman sensors with angled tips
journal, January 2000

Comparison of fibre-optic SERS sensors with differently prepared tips
journal, August 1998

Development of silver nanorod array based fiber optic probes for SERS detection
journal, September 2011
  • Zhu, Yu; Dluhy, Richard A.; Zhao, Yiping
  • Sensors and Actuators B: Chemical, Vol. 157, Issue 1, p. 42-50
  • DOI: 10.1016/j.snb.2011.03.024