Title: Biomarkers for lymphoma

Abstract

A biomarker, method, test kit, and diagnostic system for detecting the presence of lymphoma in a person are disclosed. The lymphoma may be Hodgkin's lymphoma or non-Hodgkin's lymphoma. The person may be a high-risk subject. In one embodiment, a plasma sample from a person is obtained. The level of at least one protein listed in Table S3 in the plasma sample is measured. The level of at least one protein in the plasma sample is compared with the level in a normal or healthy subject. The lymphoma is diagnosed based upon the level of the at least one protein in the plasma sample in comparison to the normal or healthy level.

Inventors:

Zangar, Richard C.; Varnum, Susan M.

Issue Date:

2014-09-02

Research Org.:

Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)

Sponsoring Org.:

USDOE

OSTI Identifier:

1154935

Patent Number(s):

8822164

Application Number:

13/690,073

Assignee:

Battelle Memorial Institute (Richland, WA)

Patent Classifications (CPCs):

G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

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G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES

G01N2333/4737 - C-reactive protein
G01N2333/70539 - MHC-molecules, e.g. HLA-molecules
G01N2333/904 - acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase
G01N33/57407 - {Specifically defined cancers}
G01N33/57426 - {leukemia}
G01N33/57488 - {involving compounds identifable in body fluids}
G01N33/6848 - {Methods of protein analysis involving mass spectrometry}
G01N33/6893 - {related to diseases not provided for elsewhere}

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DOE Contract Number:  

AC05-76RLO1830

Resource Type:

Patent

Country of Publication:

United States

Language:

English

Subject:

59 BASIC BIOLOGICAL SCIENCES