Nucleic acid compositions and the encoding proteins

Title: Nucleic acid compositions and the encoding proteins

The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.

Inventors:: Preston, III, James F.; Chow, Virginia; Nong, Guang; Rice, John D.; St. John, Franz J.

Issue Date:: 2014-09-02

OSTI Identifier:: 1154933

Assignee:: University of Florida Research Foundation, Inc. (Gainesville, FL) GFO

Patent Number(s):: 8,822,179

Application Number:: 13/350,858

Contract Number:: FG-02GO12026; FC36-99GO10476; FC36-00GO10594

Research Org:: Univ. of Florida, Gainesville, FL (United States)

Sponsoring Org:: USDOE

Country of Publication:: United States

Language:: English

Subject:: 37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

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Works referenced in this record:

Thermophilic and thermoacidophilic biopolymer-degrading genes and enzymes from alicyclobacillus acidocaldarius and related organisms, methods
patent, December 2010

Thompson, David; Apel, William; Thompson, Vicki
US Patent Document 7,858,353
URL: http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=%2Fnetahtml%2FPTO%2Fsearch-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN%2F7858353

Bacteria engineered for fuel ethanol production: current status
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Dien, B. S.; Cotta, M. A.; Jeffries, T. W.
Applied Microbiology and Biotechnology, Vol. 63, Issue 3, p. 258-266
DOI: 10.1007/s00253-003-1444-y

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