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Title: Unnatural reactive amino acid genetic code additions

This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.
Inventors:
; ; ; ;
Issue Date:
OSTI Identifier:
1151769
Assignee:
The Scripps Research Institute (La Jolla, CA) OAK
Patent Number(s):
8,815,542
Application Number:
13/787,400
Contract Number:
FG03-00ER45812
Research Org:
The Scripps Research Inst., La Jolla, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

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