Fluidics platform and method for sample preparation and analysis

Benner, W. Henry; Dzenitis, John M.; Bennet, William J.; Baker, Brian R.

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A - human necessities
A01 - agriculture
A21 - baking
A22 - butchering
A23 - foods or foodstuffs
A24 - tobacco
A41 - wearing apparel
A42 - headwear
A43 - footwear
A44 - haberdashery
A45 - hand or travelling articles
A46 - brushware
A47 - furniture
A61 - medical or veterinary science
A62 - life-saving
A63 - sports
A99 - subject matter not otherwise provided for in this section
B - performing operations
B01 - physical or chemical processes or apparatus in general
B02 - crushing, pulverising, or disintegrating
B03 - separation of solid materials using liquids or using pneumatic tables or jigs
B04 - centrifugal apparatus or machines for carrying-out physical or chemical processes
B05 - spraying or atomising in general
B06 - generating or transmitting mechanical vibrations in general
B07 - separating solids from solids
B08 - cleaning
B09 - disposal of solid waste
B21 - mechanical metal-working without essentially removing material
B22 - casting
B23 - machine tools
B24 - grinding
B25 - hand tools
B26 - hand cutting tools
B27 - working or preserving wood or similar material
B28 - working cement, clay, or stone
B29 - working of plastics
B30 - presses
B31 - making articles of paper, cardboard or material worked in a manner analogous to paper
B32 - layered products
B33 - additive manufacturing technology
B41 - printing
B42 - bookbinding
B43 - writing or drawing implements
B44 - decorative arts
B60 - vehicles in general
B61 - railways
B62 - land vehicles for travelling otherwise than on rails
B63 - ships or other waterborne vessels
B64 - aircraft
B65 - conveying
B66 - hoisting
B67 - opening, closing {or cleaning} bottles, jars or similar containers
B68 - saddlery
B81 - microstructural technology
B82 - nanotechnology
B99 - subject matter not otherwise provided for in this section
C - chemistry
C01 - inorganic chemistry
C02 - treatment of water, waste water, sewage, or sludge
C03 - glass
C04 - cements
C05 - fertilisers
C06 - explosives
C07 - organic chemistry
C08 - organic macromolecular compounds
C09 - dyes
C10 - petroleum, gas or coke industries
C11 - animal or vegetable oils, fats, fatty substances or waxes
C12 - biochemistry
C13 - sugar industry
C14 - skins
C21 - metallurgy of iron
C22 - metallurgy
C23 - coating metallic material
C25 - electrolytic or electrophoretic processes
C30 - crystal growth
C40 - combinatorial technology
C99 - subject matter not otherwise provided for in this section
D - textiles
D01 - natural or man-made threads or fibres
D02 - yarns
D03 - weaving
D04 - braiding
D05 - sewing
D06 - treatment of textiles or the like
D07 - ropes
D10 - indexing scheme associated with sublasses of section d, relating to textiles
D21 - paper-making
D99 - subject matter not otherwise provided for in this section
E - fixed constructions
E01 - construction of roads, railways, or bridges
E02 - hydraulic engineering
E03 - water supply
E04 - building
E05 - locks
E06 - doors, windows, shutters, or roller blinds in general
E21 - earth drilling
E99 - subject matter not otherwise provided for in this section
F - mechanical engineering
F01 - machines or engines in general
F02 - combustion engines
F03 - machines or engines for liquids
F04 - positive - displacement machines for liquids
F05 - indexing schemes relating to engines or pumps in various subclasses of classes f01-f04
F15 - fluid-pressure actuators
F16 - engineering elements and units
F17 - storing or distributing gases or liquids
F21 - lighting
F22 - steam generation
F23 - combustion apparatus
F24 - heating
F25 - refrigeration or cooling
F26 - drying
F27 - furnaces
F28 - heat exchange in general
F41 - weapons
F42 - ammunition
F99 - subject matter not otherwise provided for in this section
G - physics
G01 - measuring
G02 - optics
G03 - photography
G04 - horology
G05 - controlling
G06 - computing
G07 - checking-devices
G08 - signalling
G09 - education
G10 - musical instruments
G11 - information storage
G12 - instrument details
G16 - information and communication technology [ict] specially adapted for specific application fields
G21 - nuclear physics
G99 - subject matter not otherwise provided for in this section
H - electricity
H01 - basic electric elements
H02 - generation
H03 - basic electronic circuitry
H04 - electric communication technique
H05 - electric techniques not otherwise provided for
H99 - subject matter not otherwise provided for in this section
Y - new / cross sectional technologies
Y02 - technologies or applications for mitigation or adaptation against climate change
Y04 - information or communication technologies having an impact on other technology areas
Y10 - technical subjects covered by former uspc

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Title: Fluidics platform and method for sample preparation and analysis

Abstract

Herein provided are fluidics platform and method for sample preparation and analysis. The fluidics platform is capable of analyzing DNA from blood samples using amplification assays such as polymerase-chain-reaction assays and loop-mediated-isothermal-amplification assays. The fluidics platform can also be used for other types of assays and analyzes. In some embodiments, a sample in a sealed tube can be inserted directly. The following isolation, detection, and analyzes can be performed without a user's intervention. The disclosed platform may also comprises a sample preparation system with a magnetic actuator, a heater, and an air-drying mechanism, and fluid manipulation processes for extraction, washing, elution, assay assembly, assay detection, and cleaning after reactions and between samples.

Inventors:: Benner, W. Henry; Dzenitis, John M.; Bennet, William J.; Baker, Brian R.

Issue Date:: Tue Aug 19 00:00:00 EDT 2014

Research Org.:: Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1150711

Patent Number(s):: 8808643

Application Number:: 13/228,391

Assignee:: Lawrence Livermore National Security, LLC (Livermore, CA)

Patent Classifications (CPCs):: B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

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B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
B01L2300/0864 - comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
B01L2400/0622 - distribution valves, valves having multiple inlets and/or outlets, e.g. metering valves, multi-way valves
B01L3/502715 - {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
B01L3/502738 - {characterised by integrated valves

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y10 - TECHNICAL SUBJECTS COVERED BY FORMER USPC Y10T - TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
Y10T436/2575 - Volumetric liquid transfer

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DOE Contract Number:: AC52-07NA27344

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 47 OTHER INSTRUMENTATION

Citation Formats


                    Benner, W. Henry, Dzenitis, John M., Bennet, William J., and Baker, Brian R. Fluidics platform and method for sample preparation and analysis.  United States: N. p., 2014. 
        Web.

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                    Benner, W. Henry, Dzenitis, John M., Bennet, William J., & Baker, Brian R. Fluidics platform and method for sample preparation and analysis.  United States.

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                    Benner, W. Henry, Dzenitis, John M., Bennet, William J., and Baker, Brian R. Tue .  
        "Fluidics platform and method for sample preparation and analysis".  United States.  https://www.osti.gov/servlets/purl/1150711.

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@article{osti_1150711,

  title        = {Fluidics platform and method for sample preparation and analysis},

  author       = {Benner, W. Henry and Dzenitis, John M. and Bennet, William J. and Baker, Brian R.},

  abstractNote = {Herein provided are fluidics platform and method for sample preparation and analysis. The fluidics platform is capable of analyzing DNA from blood samples using amplification assays such as polymerase-chain-reaction assays and loop-mediated-isothermal-amplification assays. The fluidics platform can also be used for other types of assays and analyzes. In some embodiments, a sample in a sealed tube can be inserted directly. The following isolation, detection, and analyzes can be performed without a user's intervention. The disclosed platform may also comprises a sample preparation system with a magnetic actuator, a heater, and an air-drying mechanism, and fluid manipulation processes for extraction, washing, elution, assay assembly, assay detection, and cleaning after reactions and between samples.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {Tue Aug 19 00:00:00 EDT 2014},

  month        = {Tue Aug 19 00:00:00 EDT 2014}

}

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Works referenced in this record:

Process for isolating nucleic acid
patent, August 1993

Boom, Willem; Adriaanse, Henriette; Kievits, Tim
US Patent Document 5,234,809
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/5234809

Photometric device
patent, February 2004

Wechsler, Mark; Barney, Howard H.; Kaye, Roger
US Patent Document 6,693,709
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/6693709

Multispectral lighting apparatus
patent, June 2012

Nolte, Andreas; Kramer, Matthias; Brehm, Michael
US Patent Document 8,203,784
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/8203784

Fluid dispensing system and valve control
patent-application, May 2002

Merten, C. William; O'Brien, Thomas
US Patent Application 09/725594; 20020064880
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20020064880

Microfluidic particle-analysis systems
patent-application, November 2004

Daridon, Antoine
US Patent Document 10/640510; 20040229349
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20040229349

Device for extracting nucleic acid from a sample
patent-application, March 2008

Petersen, Kurt E.; Taylor, Michael T.; Pourahmadi, Farzad
US Patent Application 11/977697; 20080057572
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20080057572

Multispectral Lighting Apparatus
patent-application, January 2010

Nolte, Andress; Kramer, Matthias; Brehm, Michael
US Patent Application 12/445132; 20100014157
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/20100014157

An integrated portable hand-held analyser for real-time isothermal nucleic acid amplification
journal, August 2007

Smith, Matthew C.; Steimle, George; Ivanov, Stan
Analytica Chimica Acta, Vol. 598, Issue 2, p. 286-294
https://doi.org/10.1016/j.aca.2007.07.036

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Similar Records

Title: Fluidics platform and method for sample preparation and analysis

Abstract

Citation Formats

Process for isolating nucleic acid patent, August 1993

Photometric device patent, February 2004

Multispectral lighting apparatus patent, June 2012

Fluid dispensing system and valve control patent-application, May 2002

Microfluidic particle-analysis systems patent-application, November 2004

Device for extracting nucleic acid from a sample patent-application, March 2008

Multispectral Lighting Apparatus patent-application, January 2010

An integrated portable hand-held analyser for real-time isothermal nucleic acid amplification journal, August 2007

Process for isolating nucleic acid
patent, August 1993

Photometric device
patent, February 2004

Multispectral lighting apparatus
patent, June 2012

Fluid dispensing system and valve control
patent-application, May 2002

Microfluidic particle-analysis systems
patent-application, November 2004

Device for extracting nucleic acid from a sample
patent-application, March 2008

Multispectral Lighting Apparatus
patent-application, January 2010

An integrated portable hand-held analyser for real-time isothermal nucleic acid amplification
journal, August 2007