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Title: Fluidics platform and method for sample preparation and analysis

Abstract

Herein provided are fluidics platform and method for sample preparation and analysis. The fluidics platform is capable of analyzing DNA from blood samples using amplification assays such as polymerase-chain-reaction assays and loop-mediated-isothermal-amplification assays. The fluidics platform can also be used for other types of assays and analyzes. In some embodiments, a sample in a sealed tube can be inserted directly. The following isolation, detection, and analyzes can be performed without a user's intervention. The disclosed platform may also comprises a sample preparation system with a magnetic actuator, a heater, and an air-drying mechanism, and fluid manipulation processes for extraction, washing, elution, assay assembly, assay detection, and cleaning after reactions and between samples.

Inventors:
; ; ;
Issue Date:
Research Org.:
LLNL (Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States))
Sponsoring Org.:
USDOE
OSTI Identifier:
1150711
Patent Number(s):
8,808,643
Application Number:
13/228,391
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) LLNL
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Benner, W. Henry, Dzenitis, John M., Bennet, William J., and Baker, Brian R. Fluidics platform and method for sample preparation and analysis. United States: N. p., 2014. Web.
Benner, W. Henry, Dzenitis, John M., Bennet, William J., & Baker, Brian R. Fluidics platform and method for sample preparation and analysis. United States.
Benner, W. Henry, Dzenitis, John M., Bennet, William J., and Baker, Brian R. Tue . "Fluidics platform and method for sample preparation and analysis". United States. https://www.osti.gov/servlets/purl/1150711.
@article{osti_1150711,
title = {Fluidics platform and method for sample preparation and analysis},
author = {Benner, W. Henry and Dzenitis, John M. and Bennet, William J. and Baker, Brian R.},
abstractNote = {Herein provided are fluidics platform and method for sample preparation and analysis. The fluidics platform is capable of analyzing DNA from blood samples using amplification assays such as polymerase-chain-reaction assays and loop-mediated-isothermal-amplification assays. The fluidics platform can also be used for other types of assays and analyzes. In some embodiments, a sample in a sealed tube can be inserted directly. The following isolation, detection, and analyzes can be performed without a user's intervention. The disclosed platform may also comprises a sample preparation system with a magnetic actuator, a heater, and an air-drying mechanism, and fluid manipulation processes for extraction, washing, elution, assay assembly, assay detection, and cleaning after reactions and between samples.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}

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Works referenced in this record:

An integrated portable hand-held analyser for real-time isothermal nucleic acid amplification
journal, August 2007

  • Smith, Matthew C.; Steimle, George; Ivanov, Stan
  • Analytica Chimica Acta, Vol. 598, Issue 2, p. 286-294
  • DOI: 10.1016/j.aca.2007.07.036