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Title: Plant isoflavone and isoflavanone O-methyltransferase genes

Abstract

The invention provides enzymes that encode O-methyltransferases (OMTs) from Medicago truncatula that allow modification to plant (iso)flavonoid biosynthetic pathways. In certain aspects of the invention, the genes encoding these enzymes are provided. The invention therefore allows the modification of plants for isoflavonoid content. Transgenic plants comprising such enzymes are also provided, as well as methods for improving disease resistance in plants. Methods for producing food and nutraceuticals, and the resulting compositions, are also provided.

Inventors:
; ;
Issue Date:
Research Org.:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1150638
Patent Number(s):
8809627
Application Number:
11/840,032
Assignee:
The Samuel Roberts Noble Foundation (Ardmore, OK)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Broeckling, Bettina E., Liu, Chang-Jun, and Dixon, Richard A. Plant isoflavone and isoflavanone O-methyltransferase genes. United States: N. p., 2014. Web.
Broeckling, Bettina E., Liu, Chang-Jun, & Dixon, Richard A. Plant isoflavone and isoflavanone O-methyltransferase genes. United States.
Broeckling, Bettina E., Liu, Chang-Jun, and Dixon, Richard A. Tue . "Plant isoflavone and isoflavanone O-methyltransferase genes". United States. https://www.osti.gov/servlets/purl/1150638.
@article{osti_1150638,
title = {Plant isoflavone and isoflavanone O-methyltransferase genes},
author = {Broeckling, Bettina E. and Liu, Chang-Jun and Dixon, Richard A.},
abstractNote = {The invention provides enzymes that encode O-methyltransferases (OMTs) from Medicago truncatula that allow modification to plant (iso)flavonoid biosynthetic pathways. In certain aspects of the invention, the genes encoding these enzymes are provided. The invention therefore allows the modification of plants for isoflavonoid content. Transgenic plants comprising such enzymes are also provided, as well as methods for improving disease resistance in plants. Methods for producing food and nutraceuticals, and the resulting compositions, are also provided.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {8}
}

Works referenced in this record:

Isoflavonoid methylation enzyme
patent, April 2005


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Protein tolerance to random amino acid change
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Combinatorial biochemistry in plants: the case of O-methyltransferases
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Stress responses in alfalfa (Medicago sativa L). XXII. cDNA cloning and characterization of an elicitor-inducible isoflavone 7-O-methyltransferase
journal, January 1998


Conserved sequence motifs in plant S-adenosyl-L-methionine-dependent methyltransferases
journal, January 1998


Regiospecific methylation of naringenin to ponciretin by soybean O-methyltransferase expressed in Escherichia coli
journal, September 2005