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Title: Radio-methyl vorozole and methods for making and using the same

Radiotracer vorozole compounds for in vivo and in vitro assaying, studying and imaging cytochrome P450 aromatase enzymes in humans, animals, and tissues and methods for making and using the same are provided. [N-radio-methyl] vorozole substantially separated from an N-3 radio-methyl isomer of vorozole is provided. Separation is accomplished through use of chromatography resins providing multiple mechanisms of selectivity.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1150009
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
Patent Number(s):
8,795,629
Application Number:
12/704,114
Contract Number:
AC02-98CH10886
Research Org:
BNL (Brookhaven National Laboratory (BNL), Upton, NY (United States))
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

Works referenced in this record:

Preparation and comparison of a pentafluorophenyl stationary phase for reversed-phase liquid chromatography
journal, January 1990

Chromatographic classification and comparison of commercially available reversed-phase liquid chromatographic columns containing phenyl moieties using principal component analysis
journal, June 2007
  • Euerby, Melvin R.; Petersson, Patrik; Campbell, William
  • Journal of Chromatography A, Vol. 1154, Issue 1-2, p. 138-151
  • DOI: 10.1016/j.chroma.2007.03.119

Synthesis and PET studies of [11C-cyano]letrozole (Femara), an aromatase inhibitor drug
journal, February 2009

Synthesis and activity of 1H-benzimidazole and 1H-benzotriazole derivatives as inhibitors of Acanthamoeba castellanii
journal, May 2004
  • Kopańska (née Zastąpiło), Katarzyna; Najda, Andżelika; Żebrowska, Justyna
  • Bioorganic & Medicinal Chemistry, Vol. 12, Issue 10, p. 2617-2624
  • DOI: 10.1016/j.bmc.2004.03.022

Synthesis, In Vivo Rhesus Monkey Biodistribution and In Vitro Evaluation of a 11C-Labelled Potent Aromatase Inhibitor: [N-methyl-11C]Vorozole
journal, July 1998
  • Lidström, Pelle; Bonasera, Thomas A.; Kirilovas, Dmitrijus
  • Nuclear Medicine and Biology, Vol. 25, Issue 5, p. 497-501
  • DOI: 10.1016/S0969-8051(98)00009-2

Controversies of aromatase localization in human breast cancer—Stromal versus parenchymal cells
journal, August 2007
  • Miki, Yasuhiro; Suzuki, Takashi; Sasano, Hironobu
  • The Journal of Steroid Biochemistry and Molecular Biology, Vol. 106, Issue 1-5, p. 97-101
  • DOI: 10.1016/j.jsbmb.2007.05.007

Aromatase inhibition by R 76713: Experimental and clinical pharmacology
journal, January 1989
  • Wouters, W.; De Coster, R.; Tuman, R. W.
  • Journal of Steroid Biochemistry, Vol. 34, Issue 1-6, p. 427-430
  • DOI: 10.1016/0022-4731(89)90121-0

R 76713, a new specific non-steroidal aromatase inhibitor
journal, June 1989

Comparative effects of the aromatase inhibitor R76713 and of its enantiomers R83839 and R83842 on steroid biosynthesis in vitro and in vivo
journal, December 1990
  • Wouters, Walter; de Coster, Roland; van Dun, Jacky
  • The Journal of Steroid Biochemistry and Molecular Biology, Vol. 37, Issue 6, p. 1049-1054
  • DOI: 10.1016/0960-0760(90)90464-V

Reinvestigation of the synthesis and evaluation of [N-methyl-11C]vorozole, a radiotracer targeting cytochrome P450 aromatase
journal, April 2009