Water-soluble carbon nanotube compositions for drug delivery and medicinal applications
Abstract
Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
- Inventors:
- Issue Date:
- Research Org.:
- Rice Univ., Houston, TX (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1149690
- Patent Number(s):
- 8784866
- Application Number:
- 12/245,438
- Assignee:
- William Marsh Rice University (Houston, TX); Board of Regents, The University of Texas System (Austin, TX)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
- DOE Contract Number:
- FC36-05GO15073
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2008 Oct 03
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 77 NANOSCIENCE AND NANOTECHNOLOGY
Citation Formats
Tour, James M., Lucente-Schultz, Rebecca, Leonard, Ashley, Kosynkin, Dmitry V., Price, Brandi Katherine, Hudson, Jared L., Conyers, Jr., Jodie L., Moore, Valerie C., Casscells, S. Ward, Myers, Jeffrey N., Milas, Zvonimir L., Mason, Kathy A., and Milas, Luka. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications. United States: N. p., 2014.
Web.
Tour, James M., Lucente-Schultz, Rebecca, Leonard, Ashley, Kosynkin, Dmitry V., Price, Brandi Katherine, Hudson, Jared L., Conyers, Jr., Jodie L., Moore, Valerie C., Casscells, S. Ward, Myers, Jeffrey N., Milas, Zvonimir L., Mason, Kathy A., & Milas, Luka. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications. United States.
Tour, James M., Lucente-Schultz, Rebecca, Leonard, Ashley, Kosynkin, Dmitry V., Price, Brandi Katherine, Hudson, Jared L., Conyers, Jr., Jodie L., Moore, Valerie C., Casscells, S. Ward, Myers, Jeffrey N., Milas, Zvonimir L., Mason, Kathy A., and Milas, Luka. Tue .
"Water-soluble carbon nanotube compositions for drug delivery and medicinal applications". United States. https://www.osti.gov/servlets/purl/1149690.
@article{osti_1149690,
title = {Water-soluble carbon nanotube compositions for drug delivery and medicinal applications},
author = {Tour, James M. and Lucente-Schultz, Rebecca and Leonard, Ashley and Kosynkin, Dmitry V. and Price, Brandi Katherine and Hudson, Jared L. and Conyers, Jr., Jodie L. and Moore, Valerie C. and Casscells, S. Ward and Myers, Jeffrey N. and Milas, Zvonimir L. and Mason, Kathy A. and Milas, Luka},
abstractNote = {Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {7}
}
Works referenced in this record:
Self-Organization of PEO- g raft -Single-Walled Carbon Nanotubes in Solutions and Langmuir−Blodgett Films
journal, August 2001
- Sano, Masahito; Kamino, Ayumi; Okamura, Junko
- Langmuir, Vol. 17, Issue 17
Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics
journal, March 2006
- Klumpp, Cédric; Kostarelos, Kostas; Prato, Maurizio
- Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1758, Issue 3, p. 404-412
Supramolecular Chemistry on Water-Soluble Carbon Nanotubes for Drug Loading and Delivery
journal, August 2007
- Liu, Zhuang; Sun, Xiaoming; Nakayama-Ratchford, Nozomi
- ACS Nano, Vol. 1, Issue 1
A novel in situ deprotection/coupling and iterative divergent/convergent strategy for the synthesis of oligo(1,4-phenyleneethynylene)s
journal, December 2005
- Li, Guorong; Wang, Xianhong; Wang, Fosong
- Tetrahedron Letters, Vol. 46, Issue 52
Individually Suspended Single-Walled Carbon Nanotubes in Various Surfactants
journal, October 2003
- Moore, Valerie C.; Strano, Michael S.; Haroz, Erik H.
- Nano Letters, Vol. 3, Issue 10, p. 1379-1382
Triazenes as a Stable Diazonium Source for Use in Functionalizing Carbon Nanotubes in Aqueous Suspensions
journal, May 2006
- Hudson, Jared L.; Jian, Huahua; Leonard, Ashley D.
- Chemistry of Materials, Vol. 18, Issue 11
Soluble Ultra-Short Single-Walled Carbon Nanotubes
journal, August 2006
- Chen, Zheyi; Kobashi, Kazufumi; Rauwald, Urs
- Journal of the American Chemical Society, Vol. 128, Issue 32
Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
journal, March 2004
- Nakamura, Koji; Murray, Robert J.; Joseph, Jeffrey I.
- Journal of Controlled Release, Vol. 95, Issue 3, p. 589-599
Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems
journal, May 2006
- Serra, Laura; Doménech, Jose; Peppas, Nicholas A.
- European Journal of Pharmaceutics and Biopharmaceutics, Vol. 63, Issue 1, p. 11-18
Lectin-mediated drug delivery: influence of mucin on cytoadhesion of plant lectins in vitro
journal, February 2002
- Wirth, M.
- Journal of Controlled Release, Vol. 79, Issue 1-3
Fullerene Pipes
journal, May 1998
- Liu, Jie; Rinzler, Andrew G.; Dai, Hongjie
- Science, Vol. 280, Issue 5367, p. 1253-1256
Solution Properties of Single-Walled Carbon Nanotubes
journal, October 1998
- Chen, J.
- Science, Vol. 282, Issue 5386
Fluorination of Single-Wall Carbon Nanotubes and Subsequent Derivatization Reactions
journal, December 2002
- Khabashesku, Valery N.; Billups, W. Edward; Margrave, John L.
- Accounts of Chemical Research, Vol. 35, Issue 12
Functionalized Carbon Nanotubes: Properties and Applications
journal, December 2002
- Sun, Ya-Ping; Fu, Kefu; Lin, Yi
- Accounts of Chemical Research, Vol. 35, Issue 12, p. 1096-1104
Sidewall Functionalization of Carbon Nanotubes This work was supported by the European Union under the 5th Framework Research Training Network 1999, HPRNT 1999-00011 FUNCARS.
journal, November 2001
- Holzinger, Michael; Vostrowsky, Otto; Hirsch, Andreas
- Angewandte Chemie International Edition, Vol. 40, Issue 21
Covalent chemistry of single-wall carbon nanotubes
journal, May 2002
- Bahr, Jeffrey L.; Tour, James M.
- Journal of Materials Chemistry, Vol. 12, Issue 7
Reversible water-solubilization of single-walled carbon nanotubes by polymer wrapping
journal, July 2001
- O'Connell, Michael J.; Boul, Peter; Ericson, Lars M.
- Chemical Physics Letters, Vol. 342, Issue 3-4, p. 265-271
Solvent-Free Functionalization of Carbon Nanotubes
journal, February 2003
- Dyke, Christopher A.; Tour, James M.
- Journal of the American Chemical Society, Vol. 125, Issue 5
Unbundled and Highly Functionalized Carbon Nanotubes from Aqueous Reactions
journal, September 2003
- Dyke, Christopher A.; Tour, James M.
- Nano Letters, Vol. 3, Issue 9
Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
journal, July 1998
- Rinzler, A. G.; Liu, J.; Dai, H.
- Applied Physics A: Materials Science & Processing, Vol. 67, Issue 1, p. 29-37
Gas-Phase Purification of Single-Wall Carbon Nanotubes
journal, May 2000
- Zimmerman, John L.; Bradley, Robert Kelley; Huffman, Chad B.
- Chemistry of Materials, Vol. 12, Issue 5
Purification and Characterization of Single-Wall Carbon Nanotubes
journal, February 2001
- Chiang, I. W.; Brinson, B. E.; Smalley, R. E.
- The Journal of Physical Chemistry B, Vol. 105, Issue 6
Purification and Characterization of Single-Wall Carbon Nanotubes (SWNTs) Obtained from the Gas-Phase Decomposition of CO (HiPco Process)
journal, September 2001
- Chiang, I. W.; Brinson, B. E.; Huang, A. Y.
- The Journal of Physical Chemistry B, Vol. 105, Issue 35, p. 8297-8301
Length sorting cut single wall carbon nanotubes by high performance liquid chromatography
journal, September 2002
- Farkas, Elaine; Elizabeth Anderson, M.; Chen, Zhihong
- Chemical Physics Letters, Vol. 363, Issue 1-2, p. 111-116
A Route for Bulk Separation of Semiconducting from Metallic Single-Wall Carbon Nanotubes
journal, March 2003
- Chattopadhyay, Debjit; Galeska, Izabela; Papadimitrakopoulos, Fotios
- Journal of the American Chemical Society, Vol. 125, Issue 11
Structure-Assigned Optical Spectra of Single-Walled Carbon Nanotubes
journal, November 2002
- Bachilo, S. M.
- Science, Vol. 298, Issue 5602
Electronic Structure Control of Single-Walled Carbon Nanotube Functionalization
journal, September 2003
- Strano, M. S.
- Science, Vol. 301, Issue 5639
The synthesis and properties of triazine–stilbene fluorescent brighteners containing the phenolic antioxidant [II]
journal, January 2006
- Um, S.; Lee, J.; Kang, Y.
- Dyes and Pigments, Vol. 70, Issue 2
Zebrafish: An Emerging Model System for Human Disease and Drug Discovery
journal, May 2007
- Kari, G.; Rodeck, U.; Dicker, A. P.
- Clinical Pharmacology & Therapeutics, Vol. 82, Issue 1
Oral delivery of spray dried PLGA/amifostine nanoparticles
journal, September 2004
- Pamujula, Sarala; Graves, Richard A.; Freeman, Thomas
- Journal of Pharmacy and Pharmacology, Vol. 56, Issue 9