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Title: Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

Abstract

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.

Inventors:
; ; ; ; ; ; ; ; ; ; ; ;
Issue Date:
Research Org.:
Rice Univ., Houston, TX (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1149690
Patent Number(s):
8784866
Application Number:
12/245,438
Assignee:
William Marsh Rice University (Houston, TX); Board of Regents, The University of Texas System (Austin, TX)
Patent Classifications (CPCs):
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
B - PERFORMING OPERATIONS B82 - NANOTECHNOLOGY B82Y - SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES
DOE Contract Number:  
FC36-05GO15073
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Oct 03
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Tour, James M., Lucente-Schultz, Rebecca, Leonard, Ashley, Kosynkin, Dmitry V., Price, Brandi Katherine, Hudson, Jared L., Conyers, Jr., Jodie L., Moore, Valerie C., Casscells, S. Ward, Myers, Jeffrey N., Milas, Zvonimir L., Mason, Kathy A., and Milas, Luka. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications. United States: N. p., 2014. Web.
Tour, James M., Lucente-Schultz, Rebecca, Leonard, Ashley, Kosynkin, Dmitry V., Price, Brandi Katherine, Hudson, Jared L., Conyers, Jr., Jodie L., Moore, Valerie C., Casscells, S. Ward, Myers, Jeffrey N., Milas, Zvonimir L., Mason, Kathy A., & Milas, Luka. Water-soluble carbon nanotube compositions for drug delivery and medicinal applications. United States.
Tour, James M., Lucente-Schultz, Rebecca, Leonard, Ashley, Kosynkin, Dmitry V., Price, Brandi Katherine, Hudson, Jared L., Conyers, Jr., Jodie L., Moore, Valerie C., Casscells, S. Ward, Myers, Jeffrey N., Milas, Zvonimir L., Mason, Kathy A., and Milas, Luka. Tue . "Water-soluble carbon nanotube compositions for drug delivery and medicinal applications". United States. https://www.osti.gov/servlets/purl/1149690.
@article{osti_1149690,
title = {Water-soluble carbon nanotube compositions for drug delivery and medicinal applications},
author = {Tour, James M. and Lucente-Schultz, Rebecca and Leonard, Ashley and Kosynkin, Dmitry V. and Price, Brandi Katherine and Hudson, Jared L. and Conyers, Jr., Jodie L. and Moore, Valerie C. and Casscells, S. Ward and Myers, Jeffrey N. and Milas, Zvonimir L. and Mason, Kathy A. and Milas, Luka},
abstractNote = {Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {7}
}

Patent:

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Works referenced in this record:

Self-Organization of PEO- g raft -Single-Walled Carbon Nanotubes in Solutions and Langmuir−Blodgett Films
journal, August 2001


Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics
journal, March 2006


Supramolecular Chemistry on Water-Soluble Carbon Nanotubes for Drug Loading and Delivery
journal, August 2007


Individually Suspended Single-Walled Carbon Nanotubes in Various Surfactants
journal, October 2003


Triazenes as a Stable Diazonium Source for Use in Functionalizing Carbon Nanotubes in Aqueous Suspensions
journal, May 2006


Soluble Ultra-Short Single-Walled Carbon Nanotubes
journal, August 2006


Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
journal, March 2004


Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems
journal, May 2006


Fullerene Pipes
journal, May 1998


Solution Properties of Single-Walled Carbon Nanotubes
journal, October 1998


Fluorination of Single-Wall Carbon Nanotubes and Subsequent Derivatization Reactions
journal, December 2002


Functionalized Carbon Nanotubes:  Properties and Applications
journal, December 2002


Covalent chemistry of single-wall carbon nanotubes
journal, May 2002


Reversible water-solubilization of single-walled carbon nanotubes by polymer wrapping
journal, July 2001


Solvent-Free Functionalization of Carbon Nanotubes
journal, February 2003


Unbundled and Highly Functionalized Carbon Nanotubes from Aqueous Reactions
journal, September 2003


Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
journal, July 1998


Gas-Phase Purification of Single-Wall Carbon Nanotubes
journal, May 2000


Purification and Characterization of Single-Wall Carbon Nanotubes
journal, February 2001


Purification and Characterization of Single-Wall Carbon Nanotubes (SWNTs) Obtained from the Gas-Phase Decomposition of CO (HiPco Process)
journal, September 2001


Length sorting cut single wall carbon nanotubes by high performance liquid chromatography
journal, September 2002


A Route for Bulk Separation of Semiconducting from Metallic Single-Wall Carbon Nanotubes
journal, March 2003

  • Chattopadhyay, Debjit; Galeska, Izabela; Papadimitrakopoulos, Fotios
  • Journal of the American Chemical Society, Vol. 125, Issue 11
  • https://doi.org/10.1021/ja028599l

Structure-Assigned Optical Spectra of Single-Walled Carbon Nanotubes
journal, November 2002


Zebrafish: An Emerging Model System for Human Disease and Drug Discovery
journal, May 2007


Oral delivery of spray dried PLGA/amifostine nanoparticles
journal, September 2004