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Title: Water-soluble carbon nanotube compositions for drug delivery and medicinal applications

Compositions comprising a plurality of functionalized carbon nanotubes and at least one type of payload molecule are provided herein. The compositions are soluble in water and PBS in some embodiments. In certain embodiments, the payload molecules are insoluble in water. Methods are described for making the compositions and administering the compositions. An extended release formulation for paclitaxel utilizing functionalized carbon nanotubes is also described.
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Issue Date:
OSTI Identifier:
William Marsh Rice University (Houston, TX); Board of Regents, The University of Texas System (Austin, TX) GFO
Patent Number(s):
Application Number:
Contract Number:
Resource Relation:
Patent File Date: 2008 Oct 03
Research Org:
William Marsh Rice University, Houston, TX (United States)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Functionalized carbon nanotubes as emerging nanovectors for the delivery of therapeutics
journal, March 2006
  • Klumpp, Cédric; Kostarelos, Kostas; Prato, Maurizio
  • Biochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 1758, Issue 3, p. 404-412
  • DOI: 10.1016/j.bbamem.2005.10.008

Individually Suspended Single-Walled Carbon Nanotubes in Various Surfactants
journal, October 2003
  • Moore, Valerie C.; Strano, Michael S.; Haroz, Erik H.
  • Nano Letters, Vol. 3, Issue 10, p. 1379-1382
  • DOI: 10.1021/nl034524j

Oral insulin delivery using P(MAA-g-EG) hydrogels: effects of network morphology on insulin delivery characteristics
journal, March 2004
  • Nakamura, Koji; Murray, Robert J.; Joseph, Jeffrey I.
  • Journal of Controlled Release, Vol. 95, Issue 3, p. 589-599
  • DOI: 10.1016/j.jconrel.2003.12.022

Design of poly(ethylene glycol)-tethered copolymers as novel mucoadhesive drug delivery systems
journal, May 2006
  • Serra, Laura; Doménech, Jose; Peppas, Nicholas A.
  • European Journal of Pharmaceutics and Biopharmaceutics, Vol. 63, Issue 1, p. 11-18
  • DOI: 10.1016/j.ejpb.2005.10.011

Functionalized Carbon Nanotubes:  Properties and Applications
journal, December 2002
  • Sun, Ya-Ping; Fu, Kefu; Lin, Yi
  • Accounts of Chemical Research, Vol. 35, Issue 12, p. 1096-1104
  • DOI: 10.1021/ar010160v

Reversible water-solubilization of single-walled carbon nanotubes by polymer wrapping
journal, July 2001
  • O'Connell, Michael J.; Boul, Peter; Ericson, Lars M.
  • Chemical Physics Letters, Vol. 342, Issue 3-4, p. 265-271
  • DOI: 10.1016/S0009-2614(01)00490-0

Large-scale purification of single-wall carbon nanotubes: process, product, and characterization
journal, July 1998
  • Rinzler, A. G.; Liu, J.; Dai, H.
  • Applied Physics A: Materials Science & Processing, Vol. 67, Issue 1, p. 29-37
  • DOI: 10.1007/s003390050734

Purification and Characterization of Single-Wall Carbon Nanotubes (SWNTs) Obtained from the Gas-Phase Decomposition of CO (HiPco Process)
journal, September 2001
  • Chiang, I. W.; Brinson, B. E.; Huang, A. Y.
  • The Journal of Physical Chemistry B, Vol. 105, Issue 35, p. 8297-8301
  • DOI: 10.1021/jp0114891

Length sorting cut single wall carbon nanotubes by high performance liquid chromatography
journal, September 2002
  • Farkas, Elaine; Elizabeth Anderson, M.; Chen, Zhihong
  • Chemical Physics Letters, Vol. 363, Issue 1-2, p. 111-116
  • DOI: 10.1016/S0009-2614(02)01203-4