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Title: Toxicology and cellular effect of manufactured nanomaterials

Abstract

The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.

Inventors:
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1149613
Patent Number(s):
8,785,505
Application Number:
12/111,026
Assignee:
The Regents of the University of California (Oakland, CA)
DOE Contract Number:  
W-7405-Eng-48; AC05-CH11231
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 Apr 28
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY

Citation Formats

Chen, Fanqing. Toxicology and cellular effect of manufactured nanomaterials. United States: N. p., 2014. Web.
Chen, Fanqing. Toxicology and cellular effect of manufactured nanomaterials. United States.
Chen, Fanqing. Tue . "Toxicology and cellular effect of manufactured nanomaterials". United States. https://www.osti.gov/servlets/purl/1149613.
@article{osti_1149613,
title = {Toxicology and cellular effect of manufactured nanomaterials},
author = {Chen, Fanqing},
abstractNote = {The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {7}
}

Patent:

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Works referenced in this record:

Toxicity of Luminescent Silica Nanoparticles to Living Cells
journal, August 2007

  • Jin, Yuhui; Kannan, Shibichakravarthy; Wu, Min
  • Chemical Research in Toxicology, Vol. 20, Issue 8
  • DOI: 10.1021/tx7001959

Molecular Characterization of the Cytotoxic Mechanism of Multiwall Carbon Nanotubes and Nano-Onions on Human Skin Fibroblast
journal, December 2005

  • Ding, Lianghao; Stilwell, Jackie; Zhang, Tingting
  • Nano Letters, Vol. 5, Issue 12
  • DOI: 10.1021/nl051748o

The Rat Ear Vein Model for Investigating In Vivo Thrombogenicity of Ultrafine Particles (UFP)
journal, March 2005

  • Silva, Vanessa M.; Corson, Nancy; Elder, Alison
  • Toxicological Sciences, Vol. 85, Issue 2
  • DOI: 10.1093/toxsci/kfi142

The Differential Cytotoxicity of Water-Soluble Fullerenes
journal, October 2004

  • Sayes, Christie M.; Fortner, John D.; Guo, Wenh
  • Nano Letters, Vol. 4, Issue 10
  • DOI: 10.1021/nl0489586

Substituted Carborane-Appended Water-Soluble Single-Wall Carbon Nanotubes:  New Approach to Boron Neutron Capture Therapy Drug Delivery
journal, July 2005

  • Yinghuai, Zhu; Peng, Ang Thiam; Carpenter, Keith
  • Journal of the American Chemical Society, Vol. 127, Issue 27
  • DOI: 10.1021/ja0517116

Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
journal, August 2005

  • Shi Kam, N. W.; O'Connell, M.; Wisdom, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 33, p. 11600-11605
  • DOI: 10.1073/pnas.0502680102

Effects of Acute and Subchronic Exposure of Topically Applied Fullerene Extracts on the Mouse Skin
journal, July 1993

  • Nelson, Mark A.; Domann, Frederick E.; Bowden, G. Tim
  • Toxicology and Industrial Health, Vol. 9, Issue 4
  • DOI: 10.1177/074823379300900405

Cytotoxicity of Carbon Nanomaterials:  Single-Wall Nanotube, Multi-Wall Nanotube, and Fullerene
journal, March 2005

  • Jia, Guang; Wang, Haifang; Yan, Lei
  • Environmental Science & Technology, Vol. 39, Issue 5
  • DOI: 10.1021/es048729l

Toxicity of Gold Nanoparticles Functionalized with Cationic and Anionic Side Chains
journal, July 2004

  • Goodman, Catherine M.; McCusker, Catherine D.; Yilmaz, Tuna
  • Bioconjugate Chemistry, Vol. 15, Issue 4
  • DOI: 10.1021/bc049951i

Nanoparticle Surface Charges Alter Blood–Brain Barrier Integrity and Permeability
journal, December 2004

  • Lockman, Paul R.; Koziara, Joanna M.; Mumper, Russell J.
  • Journal of Drug Targeting, Vol. 12, Issue 9-10
  • DOI: 10.1080/10611860400015936

Cytotoxicity of Colloidal CdSe and CdSe/ZnS Nanoparticles
journal, February 2005

  • Kirchner, Christian; Liedl, Tim; Kudera, Stefan
  • Nano Letters, Vol. 5, Issue 2
  • DOI: 10.1021/nl047996m