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Title: Toxicology and cellular effect of manufactured nanomaterials

The increasing use of nanotechnology in consumer products and medical applications underlies the importance of understanding its potential toxic effects to people and the environment. Herein are described methods and assays to predict and evaluate the cellular effects of nanomaterial exposure. Exposing cells to nanomaterials at cytotoxic doses induces cell cycle arrest and increases apoptosis/necrosis, activates genes involved in cellular transport, metabolism, cell cycle regulation, and stress response. Certain nanomaterials induce genes indicative of a strong immune and inflammatory response within skin fibroblasts. Furthermore, the described multiwall carbon nanoonions (MWCNOs) can be used as a therapeutic in the treatment of cancer due to its cytotoxicity.
Inventors:
Issue Date:
OSTI Identifier:
1149613
Assignee:
The Regents of the University of California (Oakland, CA) LLNL
Patent Number(s):
8,785,505
Application Number:
12/111,026
Contract Number:
W-7405-Eng-48; AC05-CH11231
Resource Relation:
Patent File Date: 2008 Apr 28
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
77 NANOSCIENCE AND NANOTECHNOLOGY

Other works cited in this record:

Carbon nanotubes as multifunctional biological transporters and near-infrared agents for selective cancer cell destruction
journal, August 2005
  • Shi Kam, N. W.; O'Connell, M.; Wisdom, J. A.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 33, p. 11600-11605
  • DOI: 10.1073/pnas.0502680102

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