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Title: Microbial engineering for the production of fatty acids and fatty acid derivatives

Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
Inventors:
;
Issue Date:
OSTI Identifier:
1136742
Assignee:
Massachusetts Institute of Technology (Cambridge, MA) GFO
Patent Number(s):
8,765,404
Application Number:
13/039,227
Contract Number:
FC36-07GO17058
Research Org:
Massachusetts Institute of Technology, Cambridge, MA (USA)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
09 BIOMASS FUELS; 60 APPLIED LIFE SCIENCES

Other works cited in this record:

Bioprocess and Microbe Engineering for Total Carbon Utilization in Biofuel Production
patent-application, July 2011

Engineered Microbes and Methods for Microbial Oil Overproduction from Cellulosic Materials
patent-application, December 2013

Increasing unsaturated fatty acid contents in Escherichia coli by coexpression of three different genes
journal, February 2010
  • Cao, Yujin; Yang, Jianming; Xian, Mo
  • Applied Microbiology and Biotechnology, Vol. 87, Issue 1, p. 271-280
  • DOI: 10.1007/s00253-009-2377-x

First complexomic study of alkane-binding protein complexes in the yeast Yarrowia lipolytica
journal, February 2010

Perspectives of microbial oils for biodiesel production
journal, August 2008
  • Li, Qiang; Du, Wei; Liu, Dehua
  • Applied Microbiology and Biotechnology, Vol. 80, Issue 5, p. 749-756
  • DOI: 10.1007/s00253-008-1625-9

Overproduction of free fatty acids in E. coli: Implications for biodiesel production
journal, November 2008

Regulation of long chain unsaturated fatty acid synthesis in yeast
journal, March 2007
  • Martin, Charles E.; Oh, Chan-Seok; Jiang, Yide
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1771, Issue 3, p. 271-285
  • DOI: 10.1016/j.bbalip.2006.06.010

Regulation of stearoyl-CoA desaturases and role in metabolism
journal, March 2004

Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures
journal, March 2002
  • Papanikolaou, S.; Chevalot, I.; Komaitis, M.
  • Applied Microbiology and Biotechnology, Vol. 58, Issue 3, p. 308-312
  • DOI: 10.1007/s00253-001-0897-0

Fatty acid synthesis and elongation in yeast
journal, March 2007
  • Tehlivets, Oksana; Scheuringer, Kim; Kohlwein, Sepp D.
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Vol. 1771, Issue 3, p. 255-270
  • DOI: 10.1016/j.bbalip.2006.07.004

Control of fatty acid desaturation: a mechanism conserved from bacteria to humans
journal, December 2006

Control of Lipid Accumulation in the Yeast Yarrowia lipolytica
journal, October 2008
  • Beopoulos, A.; Mrozova, Z.; Thevenieau, F.
  • Applied and Environmental Microbiology, Vol. 74, Issue 24, p. 7779-7789
  • DOI: 10.1128/AEM.01412-08

Yarrowia lipolytica as a model for bio-oil production
journal, November 2009
  • Beopoulos, Athanasios; Cescut, Julien; Haddouche, Ramdane
  • Progress in Lipid Research, Vol. 48, Issue 6, p. 375-387
  • DOI: 10.1016/j.plipres.2009.08.005

Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology
journal, October 2003

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