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Title: Microbial engineering for the production of fatty acids and fatty acid derivatives

Some aspects of this invention relate to methods useful for the conversion of a carbon source to a biofuel or biofuel precursor using engineered microbes. Some aspects of this invention relate to the discovery of a key regulator of lipid metabolism in microbes. Some aspects of this invention relate to engineered microbes for biofuel or biofuel precursor production.
Issue Date:
OSTI Identifier:
Massachusetts Institute of Technology (Cambridge, MA) GFO
Patent Number(s):
Application Number:
Contract Number:
Research Org:
Massachusetts Institute of Technology, Cambridge, MA (USA)
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

Increasing unsaturated fatty acid contents in Escherichia coli by coexpression of three different genes
journal, February 2010
  • Cao, Yujin; Yang, Jianming; Xian, Mo
  • Applied Microbiology and Biotechnology, Vol. 87, Issue 1, p. 271-280
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First complexomic study of alkane-binding protein complexes in the yeast Yarrowia lipolytica
journal, February 2010

Perspectives of microbial oils for biodiesel production
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Overproduction of free fatty acids in E. coli: Implications for biodiesel production
journal, November 2008

Regulation of long chain unsaturated fatty acid synthesis in yeast
journal, March 2007
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Regulation of stearoyl-CoA desaturases and role in metabolism
journal, March 2004

Single cell oil production by Yarrowia lipolytica growing on an industrial derivative of animal fat in batch cultures
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Fatty acid synthesis and elongation in yeast
journal, March 2007
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Control of fatty acid desaturation: a mechanism conserved from bacteria to humans
journal, December 2006

Control of Lipid Accumulation in the Yeast Yarrowia lipolytica
journal, October 2008
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Yarrowia lipolytica as a model for bio-oil production
journal, November 2009
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  • DOI: 10.1016/j.plipres.2009.08.005

Bacterial hemoglobins and flavohemoglobins: versatile proteins and their impact on microbiology and biotechnology
journal, October 2003