Global to push GA events into
skip to main content

Title: Robust, self-assembled, biocompatible films

The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.
Inventors:
; ; ;
Issue Date:
OSTI Identifier:
1136180
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
Patent Number(s):
8,759,008
Application Number:
12/777,837
Contract Number:
AC51-06NA25396
Research Org:
LANL (Los Alamos National Laboratory (LANL), Los Alamos, NM (United States))
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Works referenced in this record:

Formation of self-assembled monolayers by chemisorption of derivatives of oligo(ethylene glycol) of structure HS(CH2)11(OCH2CH2)mOH on gold
journal, January 1991
  • Pale-Grosdemange, Catherine; Simon, Ethan S.; Prime, Kevin L.
  • Journal of the American Chemical Society, Vol. 113, Issue 1, p. 12-20
  • DOI: 10.1021/ja00001a002

Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers
journal, November 1993
  • Prime, Kevin L.; Whitesides, George M.
  • Journal of the American Chemical Society, Vol. 115, Issue 23, p. 10714-10721
  • DOI: 10.1021/ja00076a032

Functional PEG-Modified Thin Films for Biological Detection
journal, March 2008
  • Anderson, Aaron S.; Dattelbaum, Andrew M.; MontaƱo, Gabriel A.
  • Langmuir, Vol. 24, Issue 5, p. 2240-2247
  • DOI: 10.1021/la7033438