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Title: Robust, self-assembled, biocompatible films

The present invention provides a composite material including a substrate having an oxide surface, and, a continuous monolayer on the oxide surface, the monolayer including a silicon atom from a trifunctional alkyl/alkenyl/alkynyl silane group that attaches to the oxide surface, an alkyl/alkenyl/alkynyl portion of at least three carbon atoms, a polyalkylene glycol spacer group, and either a reactive site (e.g., a recognition ligand) or a site resistant to non-specific binding (e.g., a methoxy or the like) at the terminus of each modified SAM. The present invention further provides a sensor element, a sensor array and a method of sensing, each employing the composite material. Patterning is also provided together with backfilling to minimize non-specific binding.
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Issue Date:
OSTI Identifier:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
Patent Number(s):
Application Number:
Contract Number:
Research Org:
LANL (Los Alamos National Laboratory (LANL), Los Alamos, NM (United States))
Sponsoring Org:
Country of Publication:
United States

Works referenced in this record:

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Adsorption of proteins onto surfaces containing end-attached oligo(ethylene oxide): a model system using self-assembled monolayers
journal, November 1993
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Functional PEG-Modified Thin Films for Biological Detection
journal, March 2008
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