Solid phase sequencing of biopolymers
Abstract
This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.
- Inventors:
- Issue Date:
- Research Org.:
- Sequenom, Inc., San Diego, CA (USA)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1135918
- Patent Number(s):
- 8758995
- Application Number:
- 12/852,336
- Assignee:
- Sequenom, Inc. (San Diego, CA)
- Patent Classifications (CPCs):
-
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
- DOE Contract Number:
- FG02-93ER61609
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2010 Aug 06
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 59 BASIC BIOLOGICAL SCIENCES
Citation Formats
Cantor, Charles R., and Koster, Hubert. Solid phase sequencing of biopolymers. United States: N. p., 2014.
Web.
Cantor, Charles R., & Koster, Hubert. Solid phase sequencing of biopolymers. United States.
Cantor, Charles R., and Koster, Hubert. Tue .
"Solid phase sequencing of biopolymers". United States. https://www.osti.gov/servlets/purl/1135918.
@article{osti_1135918,
title = {Solid phase sequencing of biopolymers},
author = {Cantor, Charles R. and Koster, Hubert},
abstractNote = {This invention relates to methods for detecting and sequencing target nucleic acid sequences, to mass modified nucleic acid probes and arrays of probes useful in these methods, and to kits and systems which contain these probes. Useful methods involve hybridizing the nucleic acids or nucleic acids which represent complementary or homologous sequences of the target to an array of nucleic acid probes. These probes comprise a single-stranded portion, an optional double-stranded portion and a variable sequence within the single-stranded portion. The molecular weights of the hybridized nucleic acids of the set can be determined by mass spectroscopy, and the sequence of the target determined from the molecular weights of the fragments. Probes may be affixed to a solid support such as a hybridization chip to facilitate automated molecular weight analysis and identification of the target sequence.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {6}
}
Save to My Library
You must Sign In or Create an Account in order to save documents to your library.
Works referenced in this record:
Magnetic bead purification of M13 DNA sequencing templates
journal, February 1992
- Alderton, Robert P.; Eccleston, Lynne M.; Howe, Roland P.
- Analytical Biochemistry, Vol. 201, Issue 1, p. 166-169
New methods to sequence DNA by mass spectrometry
conference, July 1990
- Brennan, Thomas; Chakel, John; Bente, P.
- OE/LASE '90, 14-19 Jan., Los Angeles, CA, SPIE Proceedings
An improved procedure for derivatization of controlled-pore glass beads for solid-phase oligonucleotide synthesis
journal, January 1990
- Damha, Masad J.; Giannaris, Paul A.; Zabarylo, Steven V.
- Nucleic Acids Research, Vol. 18, Issue 13
Fabrication of patterned DNA surfaces
journal, August 1996
- Chrisey, L.
- Nucleic Acids Research, Vol. 24, Issue 15
Time-of-flight mass spectrometry analysis of biomolecules
patent, May 1997
- Vestal, Marvin L.; Juhasz, Peter
- US Patent Document 5,627,369
Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: Evaluation using experimental models
journal, August 1992
- Southern, E. M.; Maskos, U.; Elder, J. K.
- Genomics, Vol. 13, Issue 4, p. 1008-1017
Polymer reversal on solid surfaces
patent, September 1993
- Holmes, Christopher P.
- US Patent Document 5,242,974
Two-dimensional electrophoretic analysis of proteins expressed by normal and cancerous human crypts: Application of mass spectrometry to peptide-mass fingerprinting
journal, January 1994
- Ji, Hong; Whitehead, Robert H.; Reid, Gavin E.
- Electrophoresis, Vol. 15, Issue 1
Method for preparing samples for mass analysis by desorption from a frozen solution
patent, April 1990
- Becker, Christopher H.
- US Patent Document 4,920,264
Time-of-flight mass spectrometry analysis of biomolecules
patent, April 1997
- Vestal, Marvin L.; Juhasz, Peter
- US Patent Document 5,625,184
Pulsed-Field Gel Electrophoresis of Very Large DNA Molecules
journal, June 1988
- Cantor, C. R.; Smith, C. L.; Mathew, M. K.
- Annual Review of Biophysics and Biophysical Chemistry, Vol. 17, Issue 1
Direct detection of nucleic acid hybridization on the surface of a charge coupled device
journal, January 1994
- Lamture, Jagannath B.; LBeattie, Kenneth; Burke, Barry E.
- Nucleic Acids Research, Vol. 22, Issue 11
Method for sequencing DNA using biotin-strepavidin conjugates to facilitate the purification of primer extension products
patent, January 1996
- Cocuzza, Anthony J.; Hobbs, Jr., Frank W.; Zagursky, Robert J.
- US Patent Document 5,484,701
DNA chips: An array of possibilities
journal, January 1998
- Marshall, Andrew; Hodgson, John
- Nature Biotechnology, Vol. 16, Issue 1
Methods for the detection and isolation of proteins
patent, July 1997
- Rothschild, Kenneth J.; Sonar, Sanjay M.; Olejnik, Jerzy
- US Patent Document 5,643,722
Matrix-bearing targets for maldi mass spectrometry and methods of production thereof
patent, June 1998
- Biemann, Klaus; Kochling, Heinrich
- US Patent Document 5,770,272
Synthesis of some pyrimidine 2'-amino-2'-deoxynucleosides
journal, January 1971
- Moffatt, John G.; Verheyden, Julien P. H.; Wagner, D.
- The Journal of Organic Chemistry, Vol. 36, Issue 2
End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
patent, August 1993
- Ghosh, Soumitra S.; Fahy, Eoin D.
- US Patent Document 5,237,016
Matrix-assisted laser desorption/ionization mass spectrometry of nucleic acids with wavelengths in the ultraviolet and infrared
journal, December 1992
- Nordhoff, E.; Ingendoh, A.; Cramer, R.
- Rapid Communications in Mass Spectrometry, Vol. 6, Issue 12
Solid-phase synthesis of protected peptide fragments using a trialkoxy-diphenyl-methylester resin.
journal, January 1987
- Rink, Hans
- Tetrahedron Letters, Vol. 28, Issue 33, p. 3787-3790
Probing the solution structure of the DNA-binding protein Max by a combination of proteolysis and mass spectrometry: Probing the solution structure of Max
journal, June 1995
- Cohen, Steven L.; Chait, Brian T.; Ferré-D'Amaré, Adrian R.
- Protein Science, Vol. 4, Issue 6
A new simpler photoaffinity analogue of peptidyl tRNA
journal, January 1974
- Hsiung, Nancy; Cantor, Charles R.
- Nucleic Acids Research, Vol. 1, Issue 12
Combinatorial strategies for polymer synthesis
patent, October 1997
- Winkler, James L.; Fodor, Stephen P. A.; Buchko, Christopher J.
- US Patent Document 5,677,195
Enhanced DNA sequencing by hybridization.
journal, April 1994
- Broude, N. E.; Sano, T.; Smith, C. L.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 8
DNA analyzing method
patent, July 1997
- Kambara, Hideki; Okano, Kazunori; Takahashi, Satoshi
- US Patent Document 5,650,274
Coaxial continuous flow fast atom bombardment for higher-molecular-weight peptides: Comparison with static fast atom bombardment and electrospray ionization
journal, December 1991
- Tomer, Kenneth B.; Perkins, John R.; Parker, Carol E.
- Biological Mass Spectrometry, Vol. 20, Issue 12, p. 783-788
Multiplex analysis of DNA
patent, September 1992
- Church, George M.; Kieffer-Higgins, Stephen
- US Patent Document 5,149,625
Reliable Hybridization of Oligonucleotides as Short as Six Nucleotides
journal, September 1990
- Drmanac, R.; Strezoska, Z.; Labat, I.
- DNA and Cell Biology, Vol. 9, Issue 7
Immuno-PCR
book, September 2006
- Sano, Takeshi; Cantor, Charles R.
- Reviews in Cell Biology and Molecular Medicine
Covalent immobilization of DNA onto polystyrene microwells: The molecules are only bound at the 5′ end
journal, October 1991
- Rasmussen, Søren Richard; Larsen, Mette Ravn; Rasmussen, Svend Erik
- Analytical Biochemistry, Vol. 198, Issue 1, p. 138-142
Effect of Impurities on the Matrix-Assisted Laser Desorption Mass Spectra of Single-Stranded Oligodeoxynucleotides
journal, January 1996
- Shaler, Thomas A.; Wickham, Juanita N.; Sannes, Kristin A.
- Analytical Chemistry, Vol. 68, Issue 3
Methods for fabricating microarrays of biological samples
patent, September 1998
- Brown, Patrick O'Reilly; Shalon, Tidhar
- US Patent Document 5,807,522
Mid-infrared matrix assisted laser desorption ionization with a water/glycerol matrix
journal, May 1998
- Caldwell, Kathleen L.; Murray, Kermit K.
- Applied Surface Science, Vol. 127-129, p. 242-247
Apparatus for determining DNA sequences by mass spectrometry
patent, December 1992
- Brennan, Thomas M.
- US Patent Document 5,174,962
A Streptavidin–Protein a Chimera that allows one–step production of a variety of Specific Antibody Conjugates
journal, December 1991
- Sano, Takeshi; Cantor, Charles R.
- Bio/Technology, Vol. 9, Issue 12
Automated assay machine and assay tray
patent, August 1990
- Johnson, Larry J.; Coates, Stephen R.; Loor, Rueyming
- US Patent Document 4,952,518
Identification of multiple structural domains regulating viroid pathogenicity.
journal, November 1992
- Sano, T.; Candresse, T.; Hammond, R. W.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 21
Vaporization and sequencing of nucleic acids
patent, December 1996
- Levis, Robert J.; Romano, Louis J.
- US Patent Document 5,580,733
High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers
patent, March 1999
- Shuber, Anthony P.
- US Patent Document 5,888,778
Improved Chips for Sequencing by Hybridization
journal, October 1991
- Pevzner, P. A.; Lysov, Yu. P.; Khrapko, K. R.
- Journal of Biomolecular Structure and Dynamics, Vol. 9, Issue 2
Polynucleotide determination with selectable cleavage sites
patent, October 1988
- Urdea, Mickey S.
- US Patent Document 4,775,619
Well-Defined Insoluble Primers for the Enzymatic Synthesis of Oligo- and Polynucleotides
journal, January 1978
- KÖSter, Hubert; Albersmeyer, Klaus; Skroch, Dietrich
- Hoppe-Seyler´s Zeitschrift für physiologische Chemie, Vol. 359, Issue 2
DNA Probes: Applications of the Principles of Nucleic Acid Hybridization
journal, January 1991
- Wetmur, James G.
- Critical Reviews in Biochemistry and Molecular Biology, Vol. 26, Issue 3-4
Beaded polymer supports and gels: II. Physico-chemical criteria and functionalization
journal, November 1991
- Arshady, Reza
- Journal of Chromatography A, Vol. 586, Issue 2, p. 199-219
Preparation of base-modified nucleosides suitable for non-radioactive label attachment and their incorporation into synthetic oligodeoxyribonucleotides
journal, January 1987
- Haralambidis, Jim; Chai, Miao; Tregear, Geoffrey W.
- Nucleic Acids Research, Vol. 15, Issue 12
Rapid screening of genetic polymorphisms using buccal cell DNA with detection by matrix-assisted laser desorption/ionization mass spectrometry
journal, January 1995
- Liu, Yan-Hui; Bai, Jian; Zhu, Yongdong
- Rapid Communications in Mass Spectrometry, Vol. 9, Issue 9
Very large scale immobilized polymer synthesis
patent, June 1995
- Fodor, Stephen P. A.; Stryer, Lubert; Pirrung, Michael C.
- US Patent Document 5,424,186
Sequencing exons 5 to 8 of the p53 gene by MALDI-TOF mass spectrometry
journal, April 1998
- Fu, Dong-Jing; Tang, Kai; Braun, Andreas
- Nature Biotechnology, Vol. 16, Issue 4
Infrared MALDI Mass Spectrometry of Large Nucleic Acids
journal, July 1998
- Berkenkamp, S.
- Science, Vol. 281, Issue 5374
N-acyl protecting groups for deoxynucleosides
journal, January 1981
- Köster, Hubert; Kulikowski, Konrad; Liese, Thomas
- Tetrahedron, Vol. 37, Issue 2, p. 363-369
Purification of Mbo II methylase (GAAG m A from Moraxella bovis: site specific cleavage of DNA at nine and ten base pair sequences
journal, January 1985
- McClelland, Michael; Nelson, Michael; Cantor, Charles R.
- Nucleic Acids Research, Vol. 13, Issue 20
Device for time lag focusing time-of-flight mass spectrometry
patent, July 1998
- Weinberger, Scot R.; Donlon, Edward P.; Kaplun, Yevgeny
- US Patent Document 5,777,325
Encoded combinatorial chemistry.
journal, June 1992
- Brenner, S.; Lerner, R. A.
- Proceedings of the National Academy of Sciences, Vol. 89, Issue 12
Method of constructing sequence-specific DNA-binding molecules
patent, February 1998
- Edwards, Cynthia A.; Fry, Kirk; Cantor, Charles R.
- US Patent Document 5,716,780
Method and apparatus for maldi analysis
patent, July 1998
- Hillenkamp, Franz
- US Patent Document 5,777,324
DNA sequencing by mass spectrometry
patent, November 1997
- Koster, Hubert
- US Patent Document 5,691,141
Dna Sequencing After the Human Genome Project
journal, May 1997
- Cantor, Charles R.; Tang, Kai; Graber, Joel H.
- Nucleosides and Nucleotides, Vol. 16, Issue 5-6
The Future of DNA Sequencing: Methods and Applications
book, January 1996
- Cantor, Charles R.; Broude, Natalia; Sano, Takeshi
- Mass Spectrometry in the Biological Sciences
Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces
patent, May 1995
- McGall, Glenn; Fodor, Stephen P. A.; Sheldon, Edward L.
- US Patent Document 5,412,087
Method and kit involving displacement and rehybridization of labeled polynucleotide
patent, April 1989
- Collins, Mary; Dougherty, Joseph P.; Ellwood, Marian S.
- US Patent Document 4,818,680
Method for determining nucleotide identity through extension of immobilized primer
patent, December 1999
- Goelet, Philip; Knapp, Michael R.; Anderson, Stephen
- US Patent Document 6,004,744
Optimal conditions for supercoil DNA sequencing with the Escherichia coli DNA polymerase I large fragment
journal, March 1988
- Lim, Heon M.; Pène, Jacques J.
- Gene Analysis Techniques, Vol. 5, Issue 2, p. 32-39
Synthesis of an amplifiable reporter RNA for bioassays
journal, January 1986
- Chu, Barbara C. F.; Kramer, Fred Russell; Orgel, Leslie E.
- Nucleic Acids Research, Vol. 14, Issue 14, p. 5591-5603
Advances in DNA diagnostics
journal, February 1998
- Graber, Joel H.; O'Donnell, Maryanne J.; Smith, Cassandra L.
- Current Opinion in Biotechnology, Vol. 9, Issue 1, p. 14-18
DNA base-pair substitutions detected in double-stranded DNA with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
journal, January 1995
- Benner, W.; Jaklevic, J.
- European Journal of Mass Spectrometry, Vol. 1, Issue 1
Oligonucleotide sizing using cleavable primers
patent, November 1998
- Monforte, Joseph; Becker, Christopher; Shaler, Thomas
- US Patent Document 5,830,655
Negative ion FAB mass spectrometric analysis of non-charged key intermediates in oligonucleotide synthesis: Rapid identification of partially protected dinucleoside monophosphates
journal, March 1987
- Wolter, A.; Möhringer, C.; Köster, H.
- Biological Mass Spectrometry, Vol. 14, Issue 3, p. 111-116
Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
journal, December 1991
- Nielsen, P.; Egholm, M.; Berg, R.
- Science, Vol. 254, Issue 5037
High-Speed DNA Sequencing: An Approach Based Upon Fluorescence Detection of Single Molecules
journal, October 1989
- Jett, James H.; Keller, Richard A.; Martin, John C.
- Journal of Biomolecular Structure and Dynamics, Vol. 7, Issue 2
Laser Desorption Mass Spectrometry. Part II Performance and Applications of Matrix-Assisted Laser Desorption/Ionization of Large Biomolecules
book, January 1992
- Overberg, A.; Hassenbürger, A.; Hillenkamp, F.
- Mass Spectrometry in the Biological Sciences: A Tutorial
Synthetic liposomes for enhanced uptake and delivery
patent, April 1996
- Kornberg, Arthur; Castuma, Celina
- US Patent Document 5,512,295
Synthesis and properties of dithymidine phosphate analogues containing 3′-thiothymidine
journal, January 1990
- Cosstick, Richard; Vyle, Joseph S.
- Nucleic Acids Research, Vol. 18, Issue 4
End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
patent, September 1997
- Ghosh, Soumitra S.; Fahy, Eoin D.
- US Patent Document 5,663,242
Labelling of oligonucleotides
patent, February 1989
- Dattagupta, Nanibhushan; Knowles, William J.
- US Patent Document 4,808,520
Oligonucleotides and analogues: A practical approach
journal, May 1992
- Pearson, Colin K.
- FEBS Letters, Vol. 303, Issue 1, p. 96-96
Covalent attachment of oligonucleotides to solid supports
journal, January 1987
- Ghosh, Soumitra S.; Musso, Gary F.
- Nucleic Acids Research, Vol. 15, Issue 13
Mass spectrometry from miniaturized arrays for full comparative DNA analysis
journal, December 1997
- Little, Daniel P.; Braun, Andreas; O'Donnell, Maryanne J.
- Nature Medicine, Vol. 3, Issue 12
The Facile Synthesis of 5′-Nucleotides by the Selective Phosphorylation of a Primary Hydroxyl Group of Nucleosides with Phosphoryl Chloride
journal, July 1975
- Sowa, Tsuneo; Ouchi, Shunji
- Bulletin of the Chemical Society of Japan, Vol. 48, Issue 7
An Algorithm for the DNA Sequence Generation from k-Tuple Word Contents of the Minimal Number of Random Fragments
journal, April 1991
- Drmanac, R.; Labat, I.; Crkvenjakov, R.
- Journal of Biomolecular Structure and Dynamics, Vol. 8, Issue 5
Mass resolution in time-of-flight mass spectrometers with reflectors
patent, August 1997
- Holle, Armin; Koster, Claus; Franzen, Jochen
- US Patent Document 5,654,545
Solid phase sequencing of double-stranded nucleic acids
patent, August 2002
- Fu, Dong-Jing; Cantor, Charles R.; Koster, Hubert
- US Patent Document 6,436,635
The synthesis of protected 5′-mercapto-2′,5′-dideoxyribonucleoside-3′-0-phosphorainidites; uses of 5′-mercapto-oligodeoxyribonucleotides
journal, January 1987
- Sproat, Brian S.; Beijer, Barbro; Rider, Peter
- Nucleic Acids Research, Vol. 15, Issue 12
Diagnostic reagents made by attaching cytidine containing nucleic acid probes to amino functionalized solid supports by bisulfite mediated transamination
patent, January 1992
- Cruickshank, Kenneth A.
- US Patent Document 5,082,935
Determination of oligonucleotide composition from mass spectrometrically measured molecular weight
journal, March 1993
- Pomerantz, Steven C.; Kowalak, Jeffrey A.; McCloskey, James A.
- Journal of the American Society for Mass Spectrometry, Vol. 4, Issue 3, p. 204-209
Beaded polymer supports and gels: I. Manufacturing techniques
journal, November 1991
- Arshady, Reza
- Journal of Chromatography A, Vol. 586, Issue 2, p. 181-197
β-Cyanoethyl N,N-dialkylamino/N-morpholinomonochloro phosphoamidites, new phosphitylating agents facilitating ease of deprotection and work-up of synthesized oligonucleotides
journal, January 1983
- Sinha, N. D.; Biernat, J.; Köster, H.
- Tetrahedron Letters, Vol. 24, Issue 52, p. 5843-5846
Verification of 50- to 100-mer DNA and RNA sequences with high-resolution mass spectrometry.
journal, March 1995
- Little, D. P.; Thannhauser, T. W.; McLafferty, F. W.
- Proceedings of the National Academy of Sciences, Vol. 92, Issue 6
Universal restriction endonucleases: designing novel cleavage specificities by combining adapter oligodeoxynucleotide and enzyme moieties
journal, January 1985
- Szybalski, Waclaw
- Gene, Vol. 40, Issue 2-3, p. 169-173
Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules
patent, June 1992
- Hillenkamp, Franz; Karas, Michael; Giessmann, Ulrich
- US Patent Document 5,118,937
Solid phase DNA sequencing using the biotin-avidin system
journal, January 1988
- Stahl, Stefan; Hultman, Thomas; Olsson, Anders
- Nucleic Acids Research, Vol. 16, Issue 7
Non-isotopic detection of nucleic acids using a polystyrene support-based sandwich hybridization assay and compositions useful therefor
patent, December 1995
- Ishii, Jennifer K.; Ghosh, Soumitra S.
- US Patent Document 5,474,895
Oligonucleotide sizing using immobilized cleavable primers
patent, December 1997
- Monforte, Joseph; Becker, Christopher; Shaler, Thomas
- US Patent Document 5,700,642
Method for analyzing an organic sample
patent, May 1993
- Levis, Robert J.; Romano, Louis J.
- US Patent Document 5,210,412
Efficient methods for attaching non-radioactive labels to the 5′ ends of synthetic oligodeoxyribonucleotides
journal, January 1986
- Agrawal, Sudhir; Christodoulou, Chris; Gait, Michael J.
- Nucleic Acids Research, Vol. 14, Issue 15
The thermodynamic advantage of DNA oligonucleotide 'stacking hybridization' reactions: energetics of a DNA nick
journal, February 1997
- Lane, M.
- Nucleic Acids Research, Vol. 25, Issue 3
The determination of protein, oligonucleotide and peptide molecular weights by ion-spray mass spectrometry
journal, November 1988
- Covey, Thomas R.; Bonner, Ronald F.; Shushan, Bori I.
- Rapid Communications in Mass Spectrometry, Vol. 2, Issue 11
Instrument and method for the sequencing of genome
patent, February 1994
- Beavis, Ronald; Chait, Brian T.
- US Patent Document 5,288,644
Surface-enhanced neat desorption for disorption and detection of analytes
patent, April 1999
- Hutchens, T. William; Yip, Tai-Tung
- US Patent Document 5,894,063
Immobilized molecular synthesis of systematically substituted compounds
patent, June 1996
- Holmes, Christopher P.
- US Patent Document 5,527,681
Method of ordering sequence binding preferences of a DNA-binding molecule
patent, December 1997
- Edwards, Cynthia A.; Fry, Kirk; Cantor, Charles R.
- US Patent Document 5,693,463
Solid phase sequencing of double-stranded nucleic acids
patent-application, March 2006
- Fu, Dong-Jing; Canton, Charles; Koster, Hubert
- US Patent Application 11/259426; 20060063193
Immobilization of active agents on substrates with a silane and heterobifunctional crosslinking agent
patent, December 1991
- Eigler, Frances S.; Georger, Jr., Jacque H.; Bhatia, Suresh K.
- US Patent Document 5,077,210
Method for detection of specific nucleic acid sequences
patent, February 1993
- Ullman, Edwin F.; Goodman, Thomas C.; Stull, Paul D.
- US Patent Document 5,185,243
Application of nested PCR and mass spectrometry for DNA-based virus detection: HBV-DNA detected in the majority of isolated anti-HBc positive sera
journal, January 1998
- Jurinke, Christian; Zöllner, Bernhard; Feucht, Heinz-Hubert
- Genetic Analysis: Biomolecular Engineering, Vol. 14, Issue 3, p. 97-102
Capillary zone electrophoresis-mass spectrometry using an electrospray ionization interface
journal, March 1988
- Smith, Richard D.; Olivares, Jose A.; Nguyen, Nhung T.
- Analytical Chemistry, Vol. 60, Issue 5
An oligonucleotide hybridization approach to DNA sequencing
journal, October 1989
- Khrapko, K. R.; P. Lysov, Yu; Khorlyn, A. A.
- FEBS Letters, Vol. 256, Issue 1-2, p. 118-122
The Use of 96-Well Polystyrene Plates for DNA Hybridization-Based Assays: An Evaluation of Different Approaches to Oligonucleotide Immobilization
journal, May 1995
- Nikiforov, T. T.; Rogers, Y. H.
- Analytical Biochemistry, Vol. 227, Issue 1
Mass spectrometry to assess DNA sequence polymorphisms
patent, February 1999
- Kamb, Alexander
- US Patent Document 5,869,242
Methods of preparing probe array by hybridation
patent, May 1997
- Cantor, Charles R.
- US Patent Document 5,631,134
Methods and apparatus for sequencing polymers with a statistical certainty using mass spectrometry
patent, February 1999
- Patterson, Dale H.
- US Patent Document 5,869,240
Sequence-directed DNA-binding molecules compositions and methods
patent, April 1998
- Edwards, Cynthia A.; Fry, Kirk; Cantor, Charles R.
- US Patent Document 5,738,990
Megabase-scale mapping of the HLA gene complex by pulsed field gel electrophoresis
journal, March 1987
- Lawrance, S.; Smith, C.; Srivastava, R.
- Science, Vol. 235, Issue 4794
Molecular cloning and nucleotide sequence of the streptavidin gene
journal, January 1986
- Argarana, Carlos E.; Kuntz, Irwin D.; Birken, Steven
- Nucleic Acids Research, Vol. 14, Issue 4
Methods for attaching polynucleotides to supports
patent, January 1989
- Stabinsky, Yitzhak
- US Patent Document 4,797,355
Expression vectors for streptavidin-containing chimeric proteins
journal, April 1991
- Sano, Takeshi; Cantor, Charles R.
- Biochemical and Biophysical Research Communications, Vol. 176, Issue 2, p. 571-577
A new method for sequencing DNA.
journal, February 1977
- Maxam, A. M.; Gilbert, W.
- Proceedings of the National Academy of Sciences, Vol. 74, Issue 2
1-Tuple DNA Sequencing: Computer Analysis
journal, August 1989
- Pevzner, Pavel A.
- Journal of Biomolecular Structure and Dynamics, Vol. 7, Issue 1
Quantitative multiplex sequence analysis of mutational hot spots. Frequency and specificity of mutations induced by a site-specific ethenocytosine in M13 viral DNA
journal, April 1993
- Palejwala, Vaseem A.; Rzepka, Robert W.; Simha, Devendranath
- Biochemistry, Vol. 32, Issue 15
Array-type multiple cell injector
patent, November 1993
- Leighton, Stephen B.; Brownstein, Michael J.
- US Patent Document 5,262,128
DNA diagnostics based on mass spectrometry
patent, July 2001
- Koster, Hubert; Little, Daniel P.; Braun, Andreas
- US Patent Document 6,258,538
A system for rapid DNA sequencing with fluorescent chain-terminating dideoxynucleotides
journal, October 1987
- Prober, J. M.; Trainor, G. L.; Dam, R. J.
- Science, Vol. 238, Issue 4825, p. 336-341
DNA sequencing by hybridization: 100 bases read by a non-gel-based method.
journal, November 1991
- Strezoska, Z.; Paunesku, T.; Radosavljevic, D.
- Proceedings of the National Academy of Sciences, Vol. 88, Issue 22
Laser Desorption Mass Spectrometry. Part I: Basic Mechanisms and Techniques
book, January 1992
- Hillenkamp, F.; Ehring, H.
- Mass Spectrometry in the Biological Sciences: A Tutorial
Method of sequencing of genomes by hybridization of oligonucleotide probes
patent, April 1993
- Drmanac, Radoje; Crkvenjakov, Radomir B.
- US Patent Document 5,202,231
Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry for the Detection of Polymerase Chain Reaction Products Containing 7-Deazapurine Moieties
journal, December 1996
- Siegert, C. W.; Jacob, A.; Köster, H.
- Analytical Biochemistry, Vol. 243, Issue 1
Mass spectrometric techniques in nucleic acid research
journal, September 1990
- Crain, Pamela F.
- Mass Spectrometry Reviews, Vol. 9, Issue 5
Multiplication measurement of ion mass spectra
patent, June 1990
- McLafferty, Fred W.
- US Patent Document 4,931,639
Matrix-assisted laser desorption/ionization mass spectrometry of immobilized duplex DNA probes
journal, January 1995
- Tang, Kai; Fu, Dongjing; Kötter, Sven
- Nucleic Acids Research, Vol. 23, Issue 16
Capillary gel electrophoresis for rapid, high resolution DNA sequencing
journal, January 1990
- Swerdlow, Harold; Gesteland, Raymond
- Nucleic Acids Research, Vol. 18, Issue 6
A strategy for rapid and efficient DNA sequencing by mass spectrometry
journal, September 1996
- Köster, Hubert; Tang, Kai; Fu, Dong-Jing
- Nature Biotechnology, Vol. 14, Issue 9
Oligonucleoside linkages containing adjacent nitrogen atoms
patent, April 2001
- Sanghvi, Yogesh S.; Cook, Phillip Dan
- US Patent Document 6,214,551
DNA diagnostics based on mass spectrometry
patent, May 2001
- Koster, Hubert
- US Patent Document 6,235,478
DNA diagnostic based on mass spectrometry
patent, February 1997
- Koster, Hubert
- US Patent Document 5,605,798
Detection of RET proto-oncogene codon 634 mutations using mass spectrometry
journal, October 1997
- Little, D. P.; Braun, A.; Darnhofer-Demar, B.
- Journal of Molecular Medicine, Vol. 75, Issue 10
Configurationally defined phosphorothioate-containing oligoribonucleotides in the study of the mechanism of cleavage of hammerhead ribozymes
journal, January 1991
- Slim, George; Gait, Michael J.
- Nucleic Acids Research, Vol. 19, Issue 6
Improvement of the dideoxy chain termination method of DNA sequencing by use of deoxy-7-deazaguanosine triphosphate in place of dGTP
journal, January 1986
- Mizusawa, Saeko; Nishimura, Susumu; Seela, Frank
- Nucleic Acids Research, Vol. 14, Issue 3
Electrophoresis using alternating transverse electric fields
patent, September 1984
- Cantor, Charles R.; Schwartz, David C.
- US Patent Document 4,473,452
Sequence-directed DNA-binding molecules compositions and methods
patent, November 1996
- Edwards, Cynthia A.; Cantor, Charles R.; Andrews, Beth M.
- US Patent Document 5,578,444
DNA Sequence Analysis of Human Chromosome 21 Notl Linking Clones
journal, November 1993
- Zhu, Yiwen; Cantor, Charles R.; Smith, Cassandra L.
- Genomics, Vol. 18, Issue 2
Process for the sequential observation of the successive states of a chemical reaction
patent, December 1994
- Devienne, F. Marcel
- US Patent Document 5,374,559
Bead linkers for immobilizing nucleic acids to solid supports
patent, May 1999
- Lough, David M.; Koster, Hubert
- US Patent Document 5,900,481
Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
patent, April 1995
- Walder, Joseph A.; Walder, Roxanne Y.
- US Patent Document 5,403,711
Liquid-phase hybridization and capture of hepatitis B virus DNA with magnetic beads and fluorescence detection of PCR product
journal, December 1994
- Heermann, K.-H.; Hagos, Y.; Thomssen, R.
- Journal of Virological Methods, Vol. 50, Issue 1-3, p. 43-57
Applications of Delayed Extraction Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry to Oligonucleotide Analysis
journal, January 1996
- Juhasz, Peter; Roskey, Mark T.; Smirnov, Igor P.
- Analytical Chemistry, Vol. 68, Issue 6
Solid phase sequencing of biopolymers
patent, September 2010
- Cantor, Charles R.; Koster, Hubert
- US Patent Document 7,803,529
Cyclic nucleic acid and polypeptide arrays
patent, June 1998
- Holmes, Christopher P.
- US Patent Document 5,770,456
Methods for sequencing polymers using mass spectrometry
patent, October 1998
- Patterson, Dale H.; Tarr, George E.
- US Patent Document 5,821,063
Stabilizer of dye sequencing products
patent, May 2001
- Schulz, Vincent Peter
- US Patent Document 6,232,076
Amplification of nucleic acid sequences using oligonucleotides of random sequences as primers
patent, April 1992
- Hartley, James L.; Berninger, Mark
- US Patent Document 5,106,727
DNA chain length markers and the influence of base composition on electrophoretic mobility of oligodeoxyribonucleotides in plyacrylamide-gels
journal, January 1979
- Frank, R.; Köster, H.
- Nucleic Acids Research, Vol. 6, Issue 6
Analysis of Single Mammalian Cell Lysates by Mass Spectrometry
journal, January 1996
- Li, Liang; Golding, Rafael E.; Whittal, Randy M.
- Journal of the American Chemical Society, Vol. 118, Issue 46
Fluorescence detection in automated DNA sequence analysis
journal, June 1986
- Smith, Lloyd M.; Sanders, Jane Z.; Kaiser, Robert J.
- Nature, Vol. 321, Issue 6071, p. 674-679
Efficient methods for attachment of thiol specific probes to the 3′-ends of synthetic oligodeoxyribonucleotides
journal, January 1987
- Zuckermann, Ronald; Corey, David; Schultz, Peter
- Nucleic Acids Research, Vol. 15, Issue 13
Active programmable electronic devices for molecular biological analysis and diagnostics
patent, February 1997
- Heller, Michael J.; Tu, Eugene
- US Patent Document 5,605,662
Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
patent, August 1990
- Ruth, Jerry L.
- US Patent Document 4,948,882
Method for nucleotide sequence amplification
patent, August 1996
- Miller, Glenn A.
- US Patent Document 5,545,539
DNA sequencing
patent, March 1988
- Middendorf, Lyle R.; Brumbaugh, John A.
- US Patent Document 4,729,947
Microfabrication and array technologies for DNA sequencing and diagnostics
journal, December 1996
- O'Donnell-Maloney, Maryanne J.; Little, Daniel P.
- Genetic Analysis: Biomolecular Engineering, Vol. 13, Issue 6, p. 151-157
Sequencing of surface immobilized polymers utilizing microflourescence detection
patent, August 1996
- Dower, William J.; Fodor, Stephen P. A.
- US Patent Document 5,547,839
Solid-Phase Synthesis of Oligodeoxynucleotides containing phosphoramidate internucleotide linkages and their specific chemical cleavage
journal, September 1988
- Bannwarth, Willi
- Helvetica Chimica Acta, Vol. 71, Issue 6
Method of detecting a nucleotide change in nucleic acids
patent, January 1991
- Landegren, Ulf; Hood, Leroy
- US Patent Document 4,988,617
Preparation and manipulation of large DNA molecules: advances and applications
journal, January 1987
- Smith, Cassandra L.; Cantor, Charles R.
- Trends in Biochemical Sciences, Vol. 12, p. 284-287
Parallel processing in DNA analysis
book, January 1995
- Cantor, Charles R.; Sano, Takeshi; Broude, Natalia E.
- Parallel Algorithms for Irregularly Structured Problems
Budgeting the genome
journal, January 1992
- Cantor, Charles R.
- Trends in Biotechnology, Vol. 10, p. 6-8
DNA purification by triplex-affinity capture and affinity capture electrophoresis
patent, January 1996
- Cantor, Charles R.; Ito, Takashi; Smith, Cassandra L.
- US Patent Document 5,482,836
A single-bead decode strategy using electrospray ionization mass spectrometry and a new photolabile linker: 3-Amino-3-(2-nitrophenyl)propionic acid
journal, September 1995
- Brown, Bradley B.; Wagner, David S.; Geysen, H. Mario
- Molecular Diversity, Vol. 1, Issue 1
Method for the simultaneous determination of DNA sequence variations at a large number of sites, and a kit suitable therefor
patent, November 1991
- Vijg, Jan; Uitterlinden, Andreas Gerardus
- US Patent Document 5,068,176
Method for improved mass resolution with a TOF-LD source
patent, June 1997
- Holle, Armin; Koster, Claus; Franzen, Jochen
- US Patent Document 5,641,959
Derivatization of solid supports and methods for oligomer synthesis
patent, April 1997
- Sundberg, Steven A.; Fujimoto, David
- US Patent Document 5,624,711
Laser ablation/ionizaton and mass spectrometric analysis of massive polymers
patent, August 1992
- Williams, Peter; Nelson, Randall W.
- US Patent Document 5,135,870
DNA diagnostics based on mass spectrometry
patent, April 2001
- Koster, Hubert; Higgins, G. Scott; Little, Daniel P.
- US Patent Document 6,221,601
Multiplex sequencing method using primers of different lengths to detect polymorphisms
patent, July 1999
- Tully, Gillian; Sullivan, Kevin Michael
- US Patent Document 5,925,520
DNA diagnostics based on mass spectrometry
patent, October 2001
- Koster, Hubert
- US Patent Document 6,300,076
Sequence-specific artificial photo-induced endonucleases based on triple helix-forming oligonucleotides
journal, March 1990
- Perrouault, L.; Asseline, U.; Rivalle, Christian
- Nature, Vol. 344, Issue 6264
Method of identifying nucleotide differences
patent, July 1999
- Fodor, Stephen P. A.; Solas, Dennis W.; Dower, William J.
- US Patent Document 5,925,525
Time-of-flight mass spectrometry
patent, October 1988
- Waugh, Allen Robert
- US Patent Document 4,778,993
Derivatives utilizable in nucleic acid sequencing
patent, August 1998
- Canard, Bruno; Sarfati, Simon
- US Patent Document 5,798,210
Positional Sequencing by Hybridization
patent-application, June 2003
- Cantor, Charles R.; Przetakiewicz, Marek; Smith, Cassandra L.
- US Patent Application 09/030571; 20030118987
Matrix-assisted laser desorption time-of-flight mass spectrometry of oligonucleotides using 3-hydroxypicolinic acid as an ultraviolet-sensitive matrix
journal, February 1993
- Wu, Kuang Jen; Steding, Anna; Becker, Christopher H.
- Rapid Communications in Mass Spectrometry, Vol. 7, Issue 2
Indexing linkers
patent, April 1996
- Deugau, Kenneth Victor; Unrau, Paul
- US Patent Document 5,508,169
Sequencing of megabase plus DNA by hybridization: Theory of the method
journal, February 1989
- Dramanac, Radoje; Labat, Ivan; Brukner, Ivan
- Genomics, Vol. 4, Issue 2, p. 114-128
Improved Resolution and Very High Sensitivity in MALDI TOF of Matrix Surfaces Made by Fast Evaporation
journal, October 1994
- Vorm, Ole.; Roepstorff, Peter.; Mann, Matthias.
- Analytical Chemistry, Vol. 66, Issue 19
Synthesis and properties of diastereoisomers of adenosine 5'-(O-1-thiotriphosphate) and adenosine 5'-(O-2-thiotriphosphate)
journal, April 1976
- Eckstein, Fritz; Goody, Roger S.
- Biochemistry, Vol. 15, Issue 8
7-Deaza purine bases offer a higher ion stability in the analysis of dna by matrix-assisted laser desorption/ionization mass spectrometry
journal, January 1995
- Kirpekar, F.; Nordhoff, E.; Kristiansen, K.
- Rapid Communications in Mass Spectrometry, Vol. 9, Issue 6
DNA Sequencing by Hybridization to Oligonucleotide Matrix. Calculation of Continuous Stacking Hybridization Efficiency
journal, February 1994
- Lysov, Yu. P.; Chernyi, A. A.; Balaeff, A. A.
- Journal of Biomolecular Structure and Dynamics, Vol. 11, Issue 4
Device and method for analyzing ions of high mass
patent, April 1993
- Giessmann, Ulrich; Hillenkamp, Franz; Karas, Michael
- US Patent Document 5,202,561
Time-of-flight mass spectrometry of nucleic acids by laser ablation and ionization from a frozen aqueous matrix
journal, September 1990
- Nelson, Randall W.; Thomas, Robert M.; Williams, Peter
- Rapid Communications in Mass Spectrometry, Vol. 4, Issue 9
End-attachment of oligonucleotides to polyacrylamide solid supports for capture and detection of nucleic acids
patent, December 1995
- Ghosh, Soumitra S.; Fahy, Eoin D.
- US Patent Document 5,478,893
Hybridization methods for DNA sequencing
journal, October 1991
- Bains, William
- Genomics, Vol. 11, Issue 2, p. 294-301
Methods for determining sequences information in polynucleotides using mass spectrometry
patent, March 1999
- Haff, Lawrence A.; Smirnov, Igor
- US Patent Document 5,885,775
Matrix-assisted laser-desorption mass spectrometry of DNA using an infrared free-electron laser
conference, July 1993
- Haglund, Jr., Richard F.; Tang, Kai; Hillenkamp, Franz
- OE/LASE'93: Optics, Electro-Optics, & Laser Applications in Science& Engineering, SPIE Proceedings
Multiplex DNA sequencing
journal, April 1988
- Church, G.; Kieffer-Higgins, S.
- Science, Vol. 240, Issue 4849
Detection of 500-nucleotide DNA by laser desorption mass spectrometry
journal, September 1994
- Tang, K.; Taranenko, N. I.; Allman, S. L.
- Rapid Communications in Mass Spectrometry, Vol. 8, Issue 9
Devices for performing ion-capture binding assays
patent, September 1997
- Jou, Yi-Her; Stroupe, Stephen D.; Markese, James J.
- US Patent Document 5,670,381
Ion stability of nucleic acids in infrared matrix-assisted laser desorption/ionization mass spectrometry
journal, January 1993
- Nordhoff, E.; Cramer, R.; Karas, M.
- Nucleic Acids Research, Vol. 21, Issue 15
Applications of mass spectrometry to DNA sequencing
journal, December 1991
- Jacobson, K. Bruce; Arlinghaus, Heinrich F.; Buchanan, Michelle V.
- Genetic Analysis: Biomolecular Engineering, Vol. 8, Issue 8, p. 223-229
Time-of-Flight Mass Spectrometry Of Underivatized Single-Stranded DNA Oligomers by Matrix-Assisted Laser Desorption
journal, May 1994
- Wu, Kuang Jen.; Shaler, Thomas A.; Becker, Christopher H.
- Analytical Chemistry, Vol. 66, Issue 10
Methods and compositions for the detection of sequences in selected DNA molecules
patent, August 1992
- LeMaistre, Anne; Lee, Ming-Shen
- US Patent Document 5,137,806
Rapid chromatographic technique for preparative separations with moderate resolution
journal, July 1978
- Still, W. Clark; Kahn, Michael; Mitra, Abhijit
- The Journal of Organic Chemistry, Vol. 43, Issue 14
Analysis of enzymatic DNA sequencing reactions by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
journal, January 1995
- Shaler, Thomas A.; Becker, Christopher H.; Tan, Yuping
- Rapid Communications in Mass Spectrometry, Vol. 9, Issue 10
Solid phase sequencing of double-stranded nucleic acids
patent, January 2006
- Fu, Dong-Jing; Cantor, Charles R.; Koster, Hubert
- US Patent Document 6,991,903
Solid phase synthesis of protected peptides via photolytic cleavage of the .alpha.-methylphenacyl ester anchoring linkage
journal, October 1976
- Wang, Su-Sun.
- The Journal of Organic Chemistry, Vol. 41, Issue 20
Method for determining nucleotide identity through primer extension
patent, March 1999
- Goelet, Philip; Knapp, Michael R.; Anderson, Stephen
- US Patent Document 5,888,819
Mass Spectrometry of Nucleic Acid Components
book, February 1990
- Schram, Karl H.
- Methods of Biochemical Analysis, Vol. 34
Mass spectrometric methods for sequencing nucleic acids
patent, July 2001
- Kang, Changwon; Kwon, Young Soo; Kim, Young Tae
- US Patent Document 6,268,131
Determining DNA sequences by mass spectrometry
patent, March 1991
- Brennan, Thomas M.
- US Patent Document 5,003,059
Support-bound oligonucleotides
patent, July 1995
- Southern, Edwin; Maskos, Uwe
- US Patent Document 5,436,327
Detection of oligonucleotide duplex forms by ion-spray mass spectrometry
journal, February 1993
- Ganem, Bruce; Li, Yu-Tsyr; Henion, Jack D.
- Tetrahedron Letters, Vol. 34, Issue 9, p. 1445-1448
Investigations of the metastable decay of DNA under ultraviolet matrix-assisted laser desorption/ionization conditions with post-source-decay analysis and hydrogen/deuterium exchange
journal, September 1998
- Gross, Julia; Leisner, Arne; Hillenkamp, Franz
- Journal of the American Society for Mass Spectrometry, Vol. 9, Issue 9, p. 866-878
A method for DNA sequencing by hybridization with oligonucleotide matrix
journal, January 1991
- Khrapko, K. R.; Lysov, Yu. P.; Khorlin, A. A.
- DNA Sequence, Vol. 1, Issue 6
Method and apparatus for continuous sample ice matrix production for laser desorption in mass spectrometry
patent, December 1992
- Williams, Evan; Jones, Glenn C.; Zare, Richard N.
- US Patent Document 5,171,989
The emergence of mass spectrometry in biochemical research.
journal, November 1994
- Siuzdak, G.
- Proceedings of the National Academy of Sciences, Vol. 91, Issue 24
Detection of nucleic acid sequences by invader-directed cleavage
patent, December 1998
- Brow, Mary Ann D.; Hall, Jeff; Lyamichev, Victor
- US Patent Document 5,846,717
Direct detection of synthetic and biologically generated double-stranded DNA by MALDI-TOF MS
journal, December 1997
- Little, Daniel P.; Jacob, Anette; Becker, Thomas
- International Journal of Mass Spectrometry and Ion Processes, Vol. 169-170, p. 323-330
DNA sequencing using fluorescence background electroblotting membrane
patent, May 1992
- Caldwell, Karin D.; Chu, Tun-Jen; Pitt, William G.
- US Patent Document 5,112,736
Target-dependent synthesis of an artificial gene for the synthesis of a replicatable RNA
patent, May 1992
- Kramer, Fred R.; Lizardi, Paul M.
- US Patent Document 5,112,734
Positional sequencing by hybridization
patent, December 1999
- Cantor, Charles R.; Przetakiewicz, Marek; Sano, Takeshi
- US Patent Document 6,007,987
Analytical strategies for the use of DNA probes
journal, February 1988
- Matthews, Jayne A.; Kricka, Larry J.
- Analytical Biochemistry, Vol. 169, Issue 1, p. 1-25
Volatilization of high molecular weight DNA by pulsed laser ablation of frozen aqueous solutions
journal, December 1989
- Nelson, R.; Rainbow, M.; Lohr, D.
- Science, Vol. 246, Issue 4937
Improved electrospray ionization of synthetic oligodeoxynucleotides
journal, August 1991
- Stults, John T.; Marsters, James C.; Carr, Steven A.
- Rapid Communications in Mass Spectrometry, Vol. 5, Issue 8
Nucleic acid detection methods
patent, May 1998
- Smith, Cassandra L.; Yaar, Ron; Szafranski, Przemyslaw
- US Patent Document 5,753,439
Methods for amino acid sequencing of a polypeptide
patent, August 1993
- Aebersold, Rudolf
- US Patent Document 5,240,859
Oligonucleotide-linked magnetic particles and uses thereof
patent, April 1996
- Hornes, Erik; Korsnes, Lars
- US Patent Document 5,512,439
Improved Analysis of Microsatellites Using Mass Spectrometry
journal, November 1997
- Braun, Andreas; Little, Daniel P.; Reuter, Dirk
- Genomics, Vol. 46, Issue 1
Automated multi-purpose analytical chemistry processing center and laboratory work station
patent, April 1992
- Pfost, Dale R.; Bjornson, Torleif Ove; Coppock, Robert M.
- US Patent Document 5,108,703
Attomole-Sensitivity Electrospray Source for Large-Molecule Mass Spectrometry
journal, October 1995
- Valaskovic, Gary A.; Kelleher, Neil L.; Little, Daniel P.
- Analytical Chemistry, Vol. 67, Issue 20
Single-stranded labelled oligonucleotides of preselected sequence
patent, July 1996
- Ruth, Jerry L.
- US Patent Document 5,541,313
Mass spectrometer
patent, January 1999
- Becker, Christopher; Young, Steven E.
- US Patent Document 5,864,137
Sequencing double-stranded DNA by strand displacement
journal, February 1997
- Fu, D.
- Nucleic Acids Research, Vol. 25, Issue 3
Method for replicating an array of nucleic acid probes
patent, August 1998
- Cantor, Charles R.; Przetakiewicz, Marek; Smith, Cassandra L.
- US Patent Document 5,795,714
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry: a powerful tool for the mass and sequence analysis of natural and modified oligonucleotides
journal, January 1993
- Pieles, Uwe; Zürcher, Werner; Schär, Martin
- Nucleic Acids Research, Vol. 21, Issue 14
Use of combined mass spectrometry methods for the characterization of a new variant of human hemoglobin: The double mutant hemoglobin villeparisis β77(EF1) His → Tyr, β 80 (EF4) Asn → Ser
journal, February 1996
- Promé, Danielle; Deon, Catherine; Promé, Jean-Claude
- Journal of the American Society for Mass Spectrometry, Vol. 7, Issue 2, p. 163-167
The synthesis of protected 5′-amino2′, 5′-dideoxyribonucleoside-3′-O-phosphoramidites; applications of 5′-amino-oligodeoxyribonucleotides
journal, January 1987
- Sproat, Brian S.; Beijer, Barbro; Rider, Peter
- Nucleic Acids Research, Vol. 15, Issue 15
Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation
journal, January 1992
- Maskos, Uwe; Southern, Edwin M.
- Nucleic Acids Research, Vol. 20, Issue 7
Polynucleotide determination with selectable cleavage sites
patent, June 1992
- Urdea, Michael S.
- US Patent Document 5,118,605
Integrated nucleic acid analysis system for MALDI-TOF MS
patent, February 1998
- Hancock, William S.; Chakel, John A.; Apffel, James
- US Patent Document 5,716,825
Efficient preparation of short DNA sequence ladders potentially suitable for MALDI-TOF DNA sequencing
journal, January 1996
- Fu, Dong-Jing; Broude, Natalia E.; Köster, Hubert
- Genetic Analysis: Biomolecular Engineering, Vol. 12, Issue 3-4, p. 137-142
Oligonucleotide hybridisations on glass supports: a novel linker for oligonucleotide synthesis and hybridisation properties of oligonucleotides synthesised in situ
journal, January 1992
- Maskos, Uwe; Southern, Edwin M.
- Nucleic Acids Research, Vol. 20, Issue 7
Method and device for the mass-spectrometric examination of fast organic ions
patent, December 1994
- Franzen, Jochen
- US Patent Document 5,373,156
DNA diagnostics based on mass spectrometry
patent, July 2001
- Koster, Hubert
- US Patent Document 6,268,144
A versatile acid-labile linker for modification of synthetic biomolecules
journal, January 1990
- Oildea, Brian D.; Coull, James M.; Köster, Hubert
- Tetrahedron Letters, Vol. 31, Issue 49, p. 7095-7098
Identification of denatured double-stranded DNA by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
journal, January 1995
- Benner, William H.; Horn, David; Katz, Joe
- Rapid Communications in Mass Spectrometry, Vol. 9, Issue 6
Apparatus and method for matrix-assisted laser desorption mass spectrometry
patent, December 1994
- Standing, Kenneth G.; Ens, Werner
- US Patent Document 5,376,788
Synthesis and screening of immobilized oligonucleotide arrays
patent, April 1996
- Fodor, Stephen P. A.; Pirrung, Michael C.; Read, J. Leighton
- US Patent Document 5,510,270
Analysis of Ligase Chain Reaction Products via Matrix-Assisted Laser Desorption/Ionization Time-of-Flight–Mass Spectrometry
journal, June 1996
- Jurinke, Christian; van den Boom, Dirk; Jacob, Anette
- Analytical Biochemistry, Vol. 237, Issue 2
DNA diagnostics--molecular techniques and automation
journal, October 1988
- Landegren, U.; Kaiser, R.; Caskey, C.
- Science, Vol. 242, Issue 4876
DNA sequencing process using stable isotopes
patent, March 1991
- Jacobson, K. Bruce; Schmitt, Harold W.
- US Patent Document 5,002,868
Positional sequencing by hybridization
patent, April 1996
- Cantor, Charles R.
- US Patent Document 5,503,980
Nucleic acid sequence determination by multiple mixed oligonucleotide probes
patent, March 1991
- Macevicz, Stephen C.
- US Patent Document 5,002,867
Process for the preparation of oligonucleotides
patent, February 1988
- Koster, Hubert; Sinha, Nanda
- US Patent Document 4,725,677
Systems and methods for performing reactions in an unsealed environment
patent, May 2001
- Becker, Thomas; Koster, Hubert; Cantor, Charles R.
- US Patent Document 6,225,061
Method of detecting nucleic acids
patent, September 1998
- Fodor, Stephen P. A.; Solas, Dennis W.; Dower, William J.
- US Patent Document 5,800,992
Superconductor bandpass filter having parameters changed by a variable magnetic penetration depth
patent, June 1998
- Grothe, Wolfgang; Voigtlaender, Klaus; Klauda, Matthias
- US Patent Document 5,770,546
Matrix-assisted laser desorption mass spectrometry of oligodeoxythmidylic acids
journal, March 1992
- Huth-Fehre, T.; Gosine, J. N.; Wu, K. J.
- Rapid Communications in Mass Spectrometry, Vol. 6, Issue 3
Detection of hepatitis B virus DNA in serum samples via nested PCR and MALDI-TOF mass spectrometry
journal, September 1996
- Jurinke, C.; Zöllner, B.; Feucht, H.-H.
- Genetic Analysis: Biomolecular Engineering, Vol. 13, Issue 3, p. 67-71
Genetic Bit Analysis: a solid phase method for typing single nucleotide polymorphisms
journal, January 1994
- Nikiforov, Theo T.; Rendie, Robert B.; Goelet, Philip
- Nucleic Acids Research, Vol. 22, Issue 20
Fluorescent reagents for the preparation of 5'-tagged oligonucleotides
patent, March 1991
- Hobbs, Jr., Frank W.
- US Patent Document 4,997,928
Electrospray ionization and matrix assisted laser desorption/ionization mass spectrometry: Powerful analytical tools in recombinant protein chemistry
journal, April 1996
- Andersen, Jens S.; Svensson, Birte; Roepstorff, Peter
- Nature Biotechnology, Vol. 14, Issue 4
Applications of resonance ionization spectroscopy for semiconductor, environmental and biomedical analysis, and for DNA sequencing
conference, July 1991
- Arlinghaus, Heinrich F.; Spaar, M. T.; Thonnard, N.
- Optics, Electro-Optics, and Laser Applications in Science and Engineering, SPIE Proceedings
Method for enzymatic synthesis of oligonucleotides
patent, July 1995
- Hyman, Edward
- US Patent Document 5,436,143
A 2prime;-O-thiol tether in the ribose moiety of nucleic acids for conjugation chemistry
journal, November 1994
- Manoharan, Muthiah; Tivel, Kathleen L.; Ross, Bruce
- Gene, Vol. 149, Issue 1, p. 147-156
1,7-Dideaza-2?,3?-dideoxyadenosine: Syntheses of Pyrrolo[2,3-b]pyndine 2?,3?-Dideoxyribofuranosides and Participation of Purine N(1) during HIV-1 Reverse Transcriptase Inhibition
journal, August 1991
- Seela, Frank; Gumbiowski, Rainer
- Helvetica Chimica Acta, Vol. 74, Issue 5
Methods for producing probes capable of distingushing variant genomic sequences
patent, July 1995
- Wigler, Michael; Lisitsyn, Nikolai
- US Patent Document 5,436,142
High-Resolution MALDI Fourier Transform Mass Spectrometry of Oligonucleotides
journal, January 1996
- Li, Yunzhi; Tang, Kai; Little, Daniel P.
- Analytical Chemistry, Vol. 68, Issue 13
A general method of in vitro preparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions
journal, January 1988
- Higuchi, Russell; Krummel, Barbara; Saiki, Randall
- Nucleic Acids Research, Vol. 16, Issue 15
Variable-wavelength on-column fluorescence detector for open-tubular zone electrophoresis
journal, February 1986
- Green, Jonathan S.; Jorgenson, James W.
- Journal of Chromatography A, Vol. 352, p. 337-343
Method for dissociating biotin complexes
patent, February 2000
- Jurinke, Christian; Van Den Boom, Dirk Johannes; Koster, Hubert
- US Patent Document 6,022,688
Method and structures employing chemically-labelled polynucleotide probes
patent, February 1991
- Stavrianopoulos, Jannis G.; Kirtikar, Dollie; Johnston, Kenneth H.
- US Patent Document 4,994,373
Laser desorption ionization mass monitor (LDIM)
patent, January 1995
- Weinberger, Scot R.; Egan, Robert W.; Hoppe, Thomas
- US Patent Document 5,382,793
Method of improving mass resolution in time-of-flight mass spectrometry
patent, April 1998
- Holle, Armin; Koster, Claus; Franzen, Jochen
- US Patent Document 5,742,049
Recovery of Nucleic Acids from Immobilized Biotin−Streptavidin Complexes Using Ammonium Hydroxide and Applications in MALDI-TOF Mass Spectrometry
journal, March 1997
- Jurinke, Christian; van den Boom, Dirk; Collazo, Verena
- Analytical Chemistry, Vol. 69, Issue 5
Use of a nitrocellulose film substrate in matrix-assisted laser desorption/ionization mass spectrometry for DNA mapping and screening
journal, October 1995
- Liu, Yan-Hui.; Bai, Jian.; Liang, Xiaoli.
- Analytical Chemistry, Vol. 67, Issue 19
A Filtration Method for Plasmid Isolation Using Microtiter Filter Plates
journal, September 1995
- Ruppert, A.; Szalay, B.; Vandenboom, D.
- Analytical Biochemistry, Vol. 230, Issue 1
Method of producing multiply charged ions and for determining molecular weights of molecules by use of the multiply charged ions of molecules
patent, July 1992
- Fenn, John B.; Mann, Matthias; Meng, Chin-Kai
- US Patent Document 5,130,538
Matrix for matrix-assisted laser desorption mass spectroscopy
patent, April 1996
- Pieles, Uwe
- US Patent Document 5,506,348
Electrospray ionization mass spectrometry of biomolecules
journal, June 1990
- Jardine, Ian
- Nature, Vol. 345, Issue 6277
Initiator oligonucleotides for the combination of chemical and enzymatic RNA synthesis
journal, March 1992
- Pitulle, Christian; Kleineidam, Reinhard G.; Sproat, Brian
- Gene, Vol. 112, Issue 1, p. 101-105
The development of microfabricated arrays for DNA sequencing and analysis
journal, October 1996
- O'Donnell-Maloney, Maryanne J.; Smith, Cassandra L.; Cantor, Charles R.
- Trends in Biotechnology, Vol. 14, Issue 10, p. 401-407
Applications of dioxetane chemiluminescent probes to molecular biology
journal, November 1990
- Beck, Stephan.; Koster, Hubert.
- Analytical Chemistry, Vol. 62, Issue 21
[57] Sequencing end-labeled DNA with base-specific chemical cleavages
book, January 1980
- Maxam, Allan M.; Gilbert, Walter
- Nucleic Acids Part I
Mass spectrometry of laser-desorbed oligonucleotides
journal, June 1992
- Tang, K.; Allman, S. L.; Chen, C. H.
- Rapid Communications in Mass Spectrometry, Vol. 6, Issue 6
DNA sequencing by mass spectrometry via exonuclease degradation
patent, April 1997
- K. oster, Hubert
- US Patent Document 5,622,824
Direct sequencing of polymerase chain reaction amplified DNA fragments through the incorporation of deoxynucleoside α-thiotriphosphates
journal, January 1988
- Nakamaye, Kay L.; Gish, Gerald; Eckstein, Fritz
- Nucleic Acids Research, Vol. 16, Issue 21
Magnetic DNA hybridization properties of oligonucleotide probes attached to superparamagnetic beads and their use in the isolation of poly(A) mRNA from eukaryotic cells
journal, October 1990
- Hornes, Erik; Korsnes, Lars
- Gene Analysis Techniques, Vol. 7, Issue 6, p. 145-150
Systems and methods for performing reactions in an unsealed environment
patent, November 2002
- Becker, Thomas; Koster, Hubert; Cantor, Charles R.
- US Patent Document 6,485,913
Increased stability of nucleic acids containing 7-deaza-guanosine and 7-deaza-adenosine may enable rapid DNA sequencing by matrix-assisted laser desorption mass spectrometry
journal, January 1995
- Schneider, Klaus; Chait, Brian T.
- Nucleic Acids Research, Vol. 23, Issue 9
Matrix-assisted laser desorption/ionization of restriction enzyme-digested DNA
journal, February 1994
- Tang, K.; Allman, S. L.; Chen, C. H.
- Rapid Communications in Mass Spectrometry, Vol. 8, Issue 2
Time of flight mass spectrometry of DNA laser-ablated from frozen aqueous solutions: applications to the Human Genome Project
journal, February 1994
- Williams, Peter
- International Journal of Mass Spectrometry and Ion Processes, Vol. 131, p. 335-344
Method of vaporizing a sample substance
patent, November 1991
- Schlag, Edward W.; Lindner, Jorg; Beavis, Ronald
- US Patent Document 5,062,935
Assessment of methods for covalent binding of nucleic acids to magnetic beads, DynabeadsTM, and the characteristics of the bound nucleic acids in hybridization reactions
journal, November 1988
- Lund, V.; Schmid, R.; Rickwood, D.
- Nucleic Acids Research, Vol. 16, Issue 22
Detection of ΔF508 mutation of the cystic fibrosis gene by matrix-assisted laser desorption/ionization mass spectrometry
journal, January 1995
- Ch'Ang, L. -Y.; Schell, M.; Ringelberg, C.
- Rapid Communications in Mass Spectrometry, Vol. 9, Issue 9
Oligonucleotides, part 5+: synthesis and fluorescence studies of DNA oligomers d(AT) 5 containing adenines covalently linked at C-8 with dansyl fluorophore
journal, January 1990
- Singh, Devender; Kumar, Vijayanti; Ganesh, K. N.
- Nucleic Acids Research, Vol. 18, Issue 11
Matrix-assisted laser desorption/ionisation mass spectrometry of transfer ribonucleic acids isolated from yeast
journal, May 1997
- Grui -Sovulj, I.; Ludemann, H. -C.; Hillenkamp, F.
- Nucleic Acids Research, Vol. 25, Issue 9
HB Abruzzo [β143(H21)HIS→ARG] Identified by Mass Spectrometry and DNA Analysis
journal, January 1993
- Mosca, A.; Paleari, R.; Rubino, F. M.
- Hemoglobin, Vol. 17, Issue 3
Screening assay for the detection of DNA-binding molecules
patent, March 1998
- Edwards, Cynthia A.; Cantor, Charles R.; Andrews, Beth M.
- US Patent Document 5,726,014
Device for solid phase sequencing of nucleic acid fragments
patent, November 1989
- Rosenthal, Andre; Hunger, Hans-Dieter; Kagelmaker, Horst
- US Patent Document 4,882,127
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
patent, July 1987
- Mullis, Kary B.; Erlich, Henry A.; Arnheim, Norman
- US Patent Document 4,683,195
Method for detection of polymorphic restriction sites and nucleic acid sequences
patent, July 1987
- Saiki, Randall K.; Erlich, Henry A.
- US Patent Document 4,683,194
Instrument and method for the laser desorption of ions in mass spectrometry
patent, September 1991
- Beavis, Ronald; Chait, Brian T.
- US Patent Document 5,045,694
Analysis of surface immobilized polymers utilizing microfluorescence detection
patent, May 1999
- Dower, William J.; Fodor, Stephen P. A.
- US Patent Document 5,902,723
Rapid detection and sequencing of specific in vitro amplified DNA sequences using solid phase methods
journal, August 1990
- Wahlberg, Johan; Lundeberg, Joakim; Hultman, Thomas
- Molecular and Cellular Probes, Vol. 4, Issue 4, p. 285-297
High-Density, Covalent Attachment of DNA to Silicon Wafers for Analysis by MALDI-TOF Mass Spectrometry
journal, July 1997
- O'Donnell, Maryanne J.; Tang, Kai; Köster, Hubert
- Analytical Chemistry, Vol. 69, Issue 13
Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
patent-application, April 2002
- Cantor, Charles R.; Siddiqi, Fouad A.
- US Patent Application 09/880988; 20020045178
Method of plasma mass analysis with reduced space charge effects
patent, January 1995
- Tanner, Scott D.; Douglas, Donald J.; Cousins, Lisa
- US Patent Document 5,381,008
Solid-phase method for the purification of DNA sequencing reactions
journal, November 1992
- Tong, Xinchun.; Smith, Lloyd.
- Analytical Chemistry, Vol. 64, Issue 22
Method of staining nucleic acids detected by non-radioactive labelling and kit of reactants for carrying out the method
patent, December 1991
- Lebacq, Philippe
- US Patent Document 5,073,483
Sputter initiated resonance ionization spectrometry
patent, April 1984
- Hurst, G. Samuel; Parks, II, James E.; Schmitt, Harold W.
- US Patent Document 4,442,354
Chemiluminescent detection of DNA: application for DNA sequencing and hybridization
journal, January 1989
- Beck, Stephen; O'Keeffe, Thomas; Coull, James M.
- Nucleic Acids Research, Vol. 17, Issue 13
Methods of preparing nucleic acids for mass spectrometric analysis
patent, October 1999
- Monforte, Joseph; Shaler, Thomas; Tan, Yuping
- US Patent Document 5,965,363
Detection of nucleic acid sequences by invader-directed cleavage
patent, December 1999
- Brow, Mary Ann D.; Hall, Jeff; Lyamichev, Victor
- US Patent Document 6,001,567
Process for DNA sequencing using oligonucleotide bank
patent, May 1992
- Blocker, Helmut
- US Patent Document 5,114,839
Liquid-end assembly for multichannel air-displacement pipette
patent, October 1988
- Rainin, Kenneth; Watson, Walter S.
- US Patent Document 4,779,467
New developments in biochemical mass spectrometry: electrospray ionization
journal, May 1990
- Smith, Richard D.; Loo, Joseph A.; Edmonds, Charles G.
- Analytical Chemistry, Vol. 62, Issue 9
Sequence-directed DNA-binding molecules compositions and methods
patent, April 1998
- Edwards, Cynthia A.; Fry, Kirk; Cantor, Charles R.
- US Patent Document 5,744,131
Spatial-velocity correlation focusing in time-of-flight mass spectrometry
patent, April 1996
- Reilly, James P.; Colby, Steven M.; King, Timothy
- US Patent Document 5,510,613
Liquid chromatography-mass spectrometry system and method
patent, December 1976
- McLafferty, Fred W.; Baldwin, Michael
- US Patent Document 3,997,298
Genetic analysis of amplified DNA with immobilized sequence-specific oligonucleotide probes.
journal, August 1989
- Saiki, R. K.; Walsh, P. S.; Levenson, C. H.
- Proceedings of the National Academy of Sciences, Vol. 86, Issue 16
Screening assay for the detection of DNA-binding molecules
patent, April 1994
- Edwards, Cynthia A.; Cantor, Charles R.; Andrews, Beth M.
- US Patent Document 5,306,619
Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions
journal, August 2009
- Heemstra, Jennifer M.; Liu, David R.
- Journal of the American Chemical Society, Vol. 131, Issue 32
DNA sequencing with chain-terminating inhibitors
journal, December 1977
- Sanger, F.; Nicklen, S.; Coulson, A. R.
- Proceedings of the National Academy of Sciences, Vol. 74, Issue 12
Oligonucleotides having selectably cleavable and/or abasic sites
patent, July 1995
- Urdea, Michael S.; Horn, Thomas
- US Patent Document 5,430,136
High-throughput DNA analysis by time-of-flight mass spectrometry
journal, March 1997
- Monforte, Joseph A.; Becker, Christopher H.
- Nature Medicine, Vol. 3, Issue 3
Polynucleotide reagents containing selectable cleavage sites
patent, January 1995
- Urdea, Michael S.
- US Patent Document 5,380,833
Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
patent, January 1998
- Eyal, Nurit; Navot, Nir
- US Patent Document 5,710,028
Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support
journal, January 1989
- Hultman, Thomas; Stahl, Stefan; Homes, Erik
- Nucleic Acids Research, Vol. 17, Issue 13
Immuno-PCR: very sensitive antigen detection by means of specific antibody-DNA conjugates
journal, October 1992
- Sano, T.; Smith, C.; Cantor, C.
- Science, Vol. 258, Issue 5079
DNA sequence analysis by MALDI mass spectrometry
journal, June 1998
- Kirpekar, F.
- Nucleic Acids Research, Vol. 26, Issue 11
Thiobenzoylation method of peptide sequencing with gas chromatography and mass spectrometric detection
patent, September 1993
- Stolowitz, Mark L.
- US Patent Document 5,246,865
Covalent attachment of synthetic DNA to self-assembled monolayer films
journal, August 1996
- Chrisey, L.
- Nucleic Acids Research, Vol. 24, Issue 15
Evolving strategies for making physical maps of mammalian chromosomes
journal, January 1989
- Smith, Cassandra L.; Cantor, Charles R.
- Genome, Vol. 31, Issue 2
New technologies for large-genome sequencing
journal, January 1989
- Martin, William J.
- Genome, Vol. 31, Issue 2
Polymer support oligonucleotide synthesis XVIII 1.2) : use of β -cyanoethyi-N,N-dialkylamino-/N-morpholino phosphoramidite of deoxynucleosides for the synthesis of DNA fragments simplifying deprotection and isolation of the final product
journal, January 1984
- Sinha, N. D.; Biernat, J.; McManus, J.
- Nucleic Acids Research, Vol. 12, Issue 11
DNA sequencing, automation, and the human genome
journal, March 1990
- Trainor, George L.
- Analytical Chemistry, Vol. 62, Issue 5
Method for in vivo selection of ligand-binding proteins
patent, May 1996
- Krebber, Klaus; Moroney, Simon; Pluckthun, Andreas
- US Patent Document 5,514,548
Apparatus for analyzing samples by electromagnetic irradiation
patent, July 1980
- Hillenkamp, Franz; Kaufmann, Raimund; Nitsche, Rainer
- US Patent Document 4,214,159
Multiple pipette samples
patent, March 1991
- Hanaway, Richard W.; Hrudicka, James
- US Patent Document 5,000,921
DNA diagnostics based on mass spectrometry
patent, August 2001
- Koster, Hubert
- US Patent Document 6,277,573
Methods for nucleic acid analysis
patent, February 1999
- Fodor, Stephen P. A.; Solas, Dennis W.; Dower, William J.
- US Patent Document 5,871,928
Immobilization of nucleic acids on derivatized nylon supports
patent, February 1989
- Carrico, Robert J.; Patterson, William L.
- US Patent Document 4,806,546
Time-of-flight mass spectrometry analysis of biomolecules
patent, June 1998
- Vestal, Marvin L.; Juhasz, Peter
- US Patent Document 5,760,393
Nucleic acid and protein binding paper
patent, February 1979
- Rabbani, Elazar
- US Patent Document 4,139,346
Nucleoside Phosphorothioates
journal, June 1985
- Eckstein, F.
- Annual Review of Biochemistry, Vol. 54, Issue 1
Methods and compositions for diagnosis and treatment of pathological conditions related to abnormal dopamine receptor expression
patent, February 2000
- Weiss, Benjamin
- US Patent Document 6,025,193