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Title: Recombinant clostridia that fix CO2 and CO and uses thereof

Abstract

The present invention relates a recombinant Clostridium expressing one or more heterologous Wood-Ljungdahl (WL) genes. In particular, the recombinant Clostridium produces a metabolite at an increased level. The present invention also relates to a method for producing a metabolite by the recombinant Clostridium.

Inventors:
; ; ; ; ;
Issue Date:
Research Org.:
University of Delaware, Newark, DE (USA).
Sponsoring Org.:
USDOE
OSTI Identifier:
1135908
Patent Number(s):
8759070
Application Number:
13/229,033
Assignee:
University of Delaware (Newark, DE)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C - CHEMISTRY C12 - BIOCHEMISTRY C12Y - ENZYMES
Resource Type:
Patent
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Papoutsakis, Eleftherios T., Al-Hinai, Mohab Ali, Jones, Shawn Williams, Indurthi, Dinesh Chanukya, Mitchell, Daniel Knox, and Fast, Alan. Recombinant clostridia that fix CO2 and CO and uses thereof. United States: N. p., 2014. Web.
Papoutsakis, Eleftherios T., Al-Hinai, Mohab Ali, Jones, Shawn Williams, Indurthi, Dinesh Chanukya, Mitchell, Daniel Knox, & Fast, Alan. Recombinant clostridia that fix CO2 and CO and uses thereof. United States.
Papoutsakis, Eleftherios T., Al-Hinai, Mohab Ali, Jones, Shawn Williams, Indurthi, Dinesh Chanukya, Mitchell, Daniel Knox, and Fast, Alan. Tue . "Recombinant clostridia that fix CO2 and CO and uses thereof". United States. https://www.osti.gov/servlets/purl/1135908.
@article{osti_1135908,
title = {Recombinant clostridia that fix CO2 and CO and uses thereof},
author = {Papoutsakis, Eleftherios T. and Al-Hinai, Mohab Ali and Jones, Shawn Williams and Indurthi, Dinesh Chanukya and Mitchell, Daniel Knox and Fast, Alan},
abstractNote = {The present invention relates a recombinant Clostridium expressing one or more heterologous Wood-Ljungdahl (WL) genes. In particular, the recombinant Clostridium produces a metabolite at an increased level. The present invention also relates to a method for producing a metabolite by the recombinant Clostridium.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {6}
}

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Works referenced in this record:

Expression of plasmid-encoded aad in Clostridium acetobutylicum M5 restores vigorous butanol production.
journal, September 1994


Basic local alignment search tool
journal, October 1990


Systems-Level Metabolic Flux Profiling Elucidates a Complete, Bifurcated Tricarboxylic Acid Cycle in Clostridium acetobutylicum
journal, July 2010


Distribution of Methanol Carbon Between Assimilation and Oxidation Pathways in Methanol-grown Pseudomonas C
journal, January 1980


Natural transfer of conjugative transposon Tn916 between gram-positive and gram-negative bacteria.
journal, January 1991


Physiology of the thermophilic acetogen Moorella thermoacetica
journal, December 2004


Bioproduction of butanol from biomass: from genes to bioreactors
journal, June 2007


Metabolic pathways of clostridia for producing butanol
journal, November 2009


Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene
journal, November 2001


Construction and Characterization of a Lactose-Inducible Promoter System for Controlled Gene Expression in Clostridium perfringens
journal, November 2010


A modular system for Clostridium shuttle plasmids
journal, July 2009


PerR acts as a switch for oxygen tolerance in the strict anaerobe Clostridium acetobutylicum
journal, May 2008


The transcriptional program underlying the physiology of clostridial sporulation
journal, January 2008


KEGG: Kyoto Encyclopedia of Genes and Genomes
journal, January 2000


Clostridium ljungdahlii represents a microbial production platform based on syngas
journal, July 2010


Gas chromatography and gateway sensors for on-line state estimation of complex fermentations (butanol-acetone fermentation)
journal, August 1985


Expression of Cloned Homologous Fermentative Genes in Clostridium Acetobutylicum ATCC 824
journal, February 1992


Genome Sequence and Comparative Analysis of the Solvent-Producing Bacterium Clostridium acetobutylicum
journal, August 2001


Engineering solventogenic clostridia
journal, October 2008


Genome Sequence of the Solvent-Producing Bacterium Clostridium carboxidivorans Strain P7T
journal, August 2010


The complete genome sequence of Moorella thermoacetica (f. Clostridium thermoaceticum)
journal, July 2008


Acetogenesis and the Wood–Ljungdahl pathway of CO2 fixation
journal, December 2008


Ethanol production from H 2 and CO 2 by a newly isolated thermophilic bacterium, Moorella sp. HUC22-1
journal, October 2004


Acetate and ethanol production from H2 and CO2by Moorella sp. using a repeated batch culture
journal, March 2005


Optimization of a heterologous pathway for the production of flavonoids from glucose
journal, July 2011


Isolation of mutants ofClostridium acetobutylicum ATCC 824 deficient in protease activity
journal, March 1993


The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome
journal, June 2006


Nitrate as a preferred electron sink for the acetogen Clostridium thermoaceticum.
journal, December 1993


Aldehyde-alcohol dehydrogenase and/or thiolase overexpression coupled with CoA transferase downregulation lead to higher alcohol titers and selectivity in Clostridium acetobutylicum fermentations
journal, January 2009


Analysis of Degenerate Variants ofClostridium acetobutylicumATCC 824
journal, February 1996


DNA Array-Based Transcriptional Analysis of Asporogenous, Nonsolventogenic Clostridium acetobutylicum Strains SKO1 and M5
journal, July 2003


mazF, a novel counter-selectable marker for unmarked chromosomal manipulation in Bacillus subtilis
journal, January 2006