Modified cyanobacteria

Vermaas, Willem F J.

Title: Modified cyanobacteria

Abstract

Disclosed is a modified photoautotrophic bacterium comprising genes of interest that are modified in terms of their expression and/or coding region sequence, wherein modification of the genes of interest increases production of a desired product in the bacterium relative to the amount of the desired product production in a photoautotrophic bacterium that is not modified with respect to the genes of interest.

Inventors:: Vermaas, Willem F J.

Issue Date:: 2014-06-17

Research Org.:: Arizona State University, Scottsdale, AZ (United States). Arizona Board of Regents

Sponsoring Org.:: USDOE

OSTI Identifier:: 1134228

Patent Number(s):: 8753840

Application Number:: 12/446,441

Assignee:: Arizona Board of Regents on behalf of Arizona State University (Scottsdale, AZ)

Patent Classifications (CPCs):: C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION

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C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
C12P23/00 - Preparation of compounds containing a cyclohexene ring having an unsaturated side chain containing at least ten carbon atoms bound by conjugated double bonds, e.g. carotenes
C12P7/625 - {Polyesters of hydroxy-carboxylic acids}
C12P7/6409 - {Fatty acids}
C12P7/6463 - {obtained from glyceride producing microorganisms, e.g. single cell oil}
C12P7/649 - {Biodiesel, i.e. Fatty acid alkyl esters}

Y - NEW / CROSS SECTIONAL TECHNOLOGIES Y02 - TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE Y02E - REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
Y02E50/10 - Biofuels

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DOE Contract Number:: FG03-01ER15251

Resource Type:: Patent

Resource Relation:: Patent File Date: 2007 Oct 19

Country of Publication:: United States

Language:: English

Subject:: 59 BASIC BIOLOGICAL SCIENCES

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                    Vermaas, Willem F J. Modified cyanobacteria.  United States: N. p., 2014. 
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                    Vermaas, Willem F J. Modified cyanobacteria.  United States.

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                    Vermaas, Willem F J. Tue .  
        "Modified cyanobacteria".  United States.  https://www.osti.gov/servlets/purl/1134228.

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@article{osti_1134228,

  title        = {Modified cyanobacteria},

  author       = {Vermaas, Willem F J.},

  abstractNote = {Disclosed is a modified photoautotrophic bacterium comprising genes of interest that are modified in terms of their expression and/or coding region sequence, wherein modification of the genes of interest increases production of a desired product in the bacterium relative to the amount of the desired product production in a photoautotrophic bacterium that is not modified with respect to the genes of interest.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {6}

}

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Methods for isoprene and pinene production in cyanobacteria
patent, July 2016

Kallas, Toivo; Nelson, Matthew; Singsaas, Eric
US Patent Document 9,382,554
URL: https://image-ppubs.uspto.gov/dirsearch-public/print/downloadPdf/9382554

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Genetically modified yeast species, and fermentation processes using genetically modified yeast

Patent Rajgarhia, Vineet; Koivuranta, Kari; Penttila, Merja; ...

Yeast cells are transformed with an exogenous xylose isomerase gene. Additional genetic modifications enhance the ability of the transformed cells to ferment xylose to ethanol or other desired fermentation products. Those modifications include deletion of non-specific or specific aldose reductase gene(s), deletion of xylitol dehydrogenase gene(s) and/or overexpression of xylulokinase.
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Title: Modified cyanobacteria

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Process for the acid hydrolysis of carbohydrate polymers and the continuous fermentation of the sugars _obtained therefrom to provide ethanol patent, December 1980

Method for producing ethanol with immobilized microorganism patent, September 1982

Continuous production of ethanol by use of flocculent zymomonas mobilis patent, November 1983

Process for preparing polynucleotides patent, July 1984

Process for amplifying nucleic acid sequences patent, July 1987

Method of site-specific alteration of RNA and production of encoded polypeptides patent, June 1993

Luminescent metal chelate labels and means for detection patent, June 1993

Luminescent metal chelate labels and means for detection patent, August 1993

Techniques for producing site-directed mutagenesis of cloned DNA patent, February 1994

Soybean transformation by microparticle bombardment patent, June 1994

Site-directed mutagenesis of DNA patent, October 1994

Method of site-specific alteration of RNA and production of encoded polypeptides patent, November 1994

Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents patent, January 1995

Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes patent, January 1995

Method for specifically altering the nucleotide sequence of RNA patent, February 1995

Method for preparing fertile transgenic corn plants patent, July 1996

Method for preparing fertile transgenic corn plants patent, July 1996

Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof patent, August 1996

Method of Agrobacterium-mediated transformation of cultured soybean cells patent, October 1996

Delivery of exogenous DNA sequences in a mammal patent, December 1996

Induction of a protective immune response in a mammal by injecting a DNA sequence patent, December 1996

Methods for stable transformation of wheat patent, March 1997

Method of site-specific alteration of RNA and production of encoded polypeptides patent, June 1997

Producing a protein in a mammal by injection of a DNA-sequence into the tongue patent, August 1997

Microinjection methods to transform arthropods with exogenous DNA patent, December 1997

Polynucleotide tuberculosis vaccine patent, April 1998

DNA-based vaccination of fish patent, July 1998

Circular site-directed mutagenesis patent, August 1998

Polyclonal antibody libraries patent, August 1998

Gene targeting in animal cells using isogenic DNA constructs patent, August 1998

Walk-through mutagenesis patent, November 1998

Tumor delivery vehicles patent, August 1999

Recombinant hepatitis virus vectors patent, November 1999

In planta method for the production of transgenic plants patent, November 1999

Enhanced practical photosynthetic CO2 mitigation patent, December 2003

Genetically modified cyanobacteria for the production of ethanol, the constructs and method thereof patent, March 2004

HY2 family of bilin reductases patent, April 2006

Process for preparing ketocarotenoids in genetically modified organisms patent, June 2008

Plants characterized by enhanced growth and methods and nucleic acid constructs useful for generating same patent-application, May 2005

Methods of increasing the production of cobalamins using cob gene expression patent-application, January 2006

Process for the production of unsaturated fatty acids patent-application, April 2006

Protein tolerance to random amino acid change journal, June 2004

Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities. journal, March 1988

Functional Analysis of Conserved Histidines in ADP-Glucose Pyrophosphorylase from Escherichia coli journal, March 1998

Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53 journal, February 1999

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence Features in the 1 Mb Region from Map Positions 64% to 92% of the Genome (Supplement) journal, January 1995

An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter journal, September 1998

Overproduction of Acetyl-CoA Carboxylase Activity Increases the Rate of Fatty Acid Biosynthesis in Escherichia coli journal, July 2000

A host-vector system for gene cloning in the cyanobacterium Synechocystis PCC 6803 journal, July 1986

Vipp1 deletion mutant of Synechocystis: A connection between bacterial phage shock and thylakoid biogenesis? journal, March 2001

VIPP1, a nuclear gene of Arabidopsis thaliana essential for thylakoid membrane formation journal, March 2001

Effects of co-expression of two higher plants genes ALD and TPI in Anabaena sp. PCC7120 on photosynthetic CO2 fixation journal, March 2005

Exogenous expression of the wheat chloroplastic fructose-1,6-bisphosphatase gene enhances photosynthesis in the transgenic cyanobacterium, Anabaena PCC7120 journal, May 2005

Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942 journal, November 1999

Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714 journal, July 1998

Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism journal, January 2010

Emissions of hydrocarbons from marine phytoplankton—Some results from controlled laboratory experiments journal, July 1996

First isolation of an isoprene synthase gene from poplar and successful expression of the gene in Escherichia coli journal, July 2001

Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro journal, July 2004

Gene expression and characterization of isoprene synthase from Populus alba journal, April 2005

Role of NtcB in Activation of Nitrate Assimilation Genes in the Cyanobacterium Synechocystis sp. Strain PCC 6803 journal, October 2001

Cyanobacterial Cell Inclusions journal, October 1984

Restoration of the wild-type locus in an RuBP carboxylase/oxygenase mutant of Synecbocystis PCC 6803 via targeted gene recombination journal, November 1992

Production of biodiesel from macroalgae by supercritical CO2 extraction and thermochemical liquefaction journal, November 2005

Photosynthetic accumulation of poly-(hydroxybutyrate) by cyanobacteria—the metabolism and potential for CO2 recycling journal, June 1999

Separation of Small Circular DNA Molecules from the Blue–green Alga Anacystis nidulans journal, August 1973

Recent Advances in Mechanistic and Synthetic Aspects of Polymerization book, January 1987

Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplication scheme journal, April 1990

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis journal, January 1981

Gene Transfer to the Desiccation-Tolerant Cyanobacterium Chroococcidiopsis journal, April 2001

Fast formation of high-purity methyl esters from vegetable oils journal, December 1998

Chemical synthesis and cloning of a tyrosine tRNA gene book, January 1979

Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation journal, June 1979

In vitro scanning saturation mutagenesis of an antibody binding pocket journal, January 1997

Human Antibodies from Combinatorial Libraries book, January 1994

Randomization of genes by PCR mutagenesis. journal, August 1992

A plasmid vector for isolation of strong promoters in Escherichia coli journal, August 1999

Process for the acid hydrolysis of carbohydrate polymers and the continuous fermentation of the sugars _obtained therefrom to provide ethanol
patent, December 1980

Method for producing ethanol with immobilized microorganism
patent, September 1982

Continuous production of ethanol by use of flocculent zymomonas mobilis
patent, November 1983

Process for preparing polynucleotides
patent, July 1984

Process for amplifying nucleic acid sequences
patent, July 1987

Method of site-specific alteration of RNA and production of encoded polypeptides
patent, June 1993

Luminescent metal chelate labels and means for detection
patent, June 1993

Luminescent metal chelate labels and means for detection
patent, August 1993

Techniques for producing site-directed mutagenesis of cloned DNA
patent, February 1994

Soybean transformation by microparticle bombardment
patent, June 1994

Site-directed mutagenesis of DNA
patent, October 1994

Method of site-specific alteration of RNA and production of encoded polypeptides
patent, November 1994

Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents
patent, January 1995

Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
patent, January 1995

Method for specifically altering the nucleotide sequence of RNA
patent, February 1995

Method for preparing fertile transgenic corn plants
patent, July 1996

Method for preparing fertile transgenic corn plants
patent, July 1996

Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof
patent, August 1996

Method of Agrobacterium-mediated transformation of cultured soybean cells
patent, October 1996

Delivery of exogenous DNA sequences in a mammal
patent, December 1996

Induction of a protective immune response in a mammal by injecting a DNA sequence
patent, December 1996

Methods for stable transformation of wheat
patent, March 1997

Method of site-specific alteration of RNA and production of encoded polypeptides
patent, June 1997

Producing a protein in a mammal by injection of a DNA-sequence into the tongue
patent, August 1997

Microinjection methods to transform arthropods with exogenous DNA
patent, December 1997

Polynucleotide tuberculosis vaccine
patent, April 1998

DNA-based vaccination of fish
patent, July 1998

Circular site-directed mutagenesis
patent, August 1998

Polyclonal antibody libraries
patent, August 1998

Gene targeting in animal cells using isogenic DNA constructs
patent, August 1998

Walk-through mutagenesis
patent, November 1998

Tumor delivery vehicles
patent, August 1999

Recombinant hepatitis virus vectors
patent, November 1999

In planta method for the production of transgenic plants
patent, November 1999

Enhanced practical photosynthetic CO2 mitigation
patent, December 2003

Genetically modified cyanobacteria for the production of ethanol, the constructs and method thereof
patent, March 2004

HY2 family of bilin reductases
patent, April 2006

Process for preparing ketocarotenoids in genetically modified organisms
patent, June 2008

Plants characterized by enhanced growth and methods and nucleic acid constructs useful for generating same
patent-application, May 2005

Methods of increasing the production of cobalamins using cob gene expression
patent-application, January 2006

Process for the production of unsaturated fatty acids
patent-application, April 2006

Protein tolerance to random amino acid change
journal, June 2004

Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities.
journal, March 1988

Functional Analysis of Conserved Histidines in ADP-Glucose Pyrophosphorylase from Escherichia coli
journal, March 1998

Disentangling the perturbational effects of amino acid substitutions in the DNA-binding domain of p53
journal, February 1999

Sequence Analysis of the Genome of the Unicellular Cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence Features in the 1 Mb Region from Map Positions 64% to 92% of the Genome (Supplement)
journal, January 1995

An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter
journal, September 1998

Overproduction of Acetyl-CoA Carboxylase Activity Increases the Rate of Fatty Acid Biosynthesis in Escherichia coli
journal, July 2000

A host-vector system for gene cloning in the cyanobacterium Synechocystis PCC 6803
journal, July 1986

Vipp1 deletion mutant of Synechocystis: A connection between bacterial phage shock and thylakoid biogenesis?
journal, March 2001

VIPP1, a nuclear gene of Arabidopsis thaliana essential for thylakoid membrane formation
journal, March 2001

Effects of co-expression of two higher plants genes ALD and TPI in Anabaena sp. PCC7120 on photosynthetic CO₂ fixation
journal, March 2005

Exogenous expression of the wheat chloroplastic fructose-1,6-bisphosphatase gene enhances photosynthesis in the transgenic cyanobacterium, Anabaena PCC7120
journal, May 2005

Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942
journal, November 1999

Distribution of the mevalonate and glyceraldehyde phosphate/pyruvate pathways for isoprenoid biosynthesis in unicellular algae and the cyanobacterium Synechocystis PCC 6714
journal, July 1998

Engineering a platform for photosynthetic isoprene production in cyanobacteria, using Synechocystis as the model organism
journal, January 2010

Emissions of hydrocarbons from marine phytoplankton—Some results from controlled laboratory experiments
journal, July 1996

First isolation of an isoprene synthase gene from poplar and successful expression of the gene in Escherichia coli
journal, July 2001

Inactivation of sll1556 in Synechocystis Strain PCC 6803 Impairs Isoprenoid Biosynthesis from Pentose Phosphate Cycle Substrates In Vitro
journal, July 2004

Gene expression and characterization of isoprene synthase from Populus alba
journal, April 2005

Role of NtcB in Activation of Nitrate Assimilation Genes in the Cyanobacterium Synechocystis sp. Strain PCC 6803
journal, October 2001

Cyanobacterial Cell Inclusions
journal, October 1984

Restoration of the wild-type locus in an RuBP carboxylase/oxygenase mutant of Synecbocystis PCC 6803 via targeted gene recombination
journal, November 1992

Production of biodiesel from macroalgae by supercritical CO2 extraction and thermochemical liquefaction
journal, November 2005

Photosynthetic accumulation of poly-(hydroxybutyrate) by cyanobacteria—the metabolism and potential for CO₂ recycling
journal, June 1999

Separation of Small Circular DNA Molecules from the Blue–green Alga Anacystis nidulans
journal, August 1973

Recent Advances in Mechanistic and Synthetic Aspects of Polymerization
book, January 1987

Blunt-end and single-strand ligations by Escherichia coli ligase: influence on an in vitro amplication scheme
journal, April 1990

Deoxynucleoside phosphoramidites—A new class of key intermediates for deoxypolynucleotide synthesis
journal, January 1981

Gene Transfer to the Desiccation-Tolerant Cyanobacterium Chroococcidiopsis
journal, April 2001

Fast formation of high-purity methyl esters from vegetable oils
journal, December 1998

Chemical synthesis and cloning of a tyrosine tRNA gene
book, January 1979

Normalisation of sister chromatid exchange frequencies in Bloom's syndrome by euploid cell hybridisation
journal, June 1979

In vitro scanning saturation mutagenesis of an antibody binding pocket
journal, January 1997

Human Antibodies from Combinatorial Libraries
book, January 1994

Randomization of genes by PCR mutagenesis.
journal, August 1992

A plasmid vector for isolation of strong promoters in Escherichia coli
journal, August 1999

The occurrence of poly-β-hydroxybutyrate in the blue-green alga, Chlorogloea fritschii
journal, June 1966

RNA splicing specificity determined by the coordinated action of RNA recognition motifs in SR proteins
journal, April 1997

High-efficiency transformation of mammalian cells by plasmid DNA.
journal, August 1987