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Title: Peptide and protein biomarkers for type 1 diabetes mellitus

Abstract

A method for identifying persons with increased risk of developing type 1 diabetes mellitus, or having type I diabetes mellitus, utilizing selected biomarkers described herein either alone or in combination. The present disclosure allows for broad based, reliable, screening of large population bases. Also provided are arrays and kits that can be used to perform such methods.

Inventors:
;
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1134213
Patent Number(s):
8,748,352
Application Number:
13/586,321
Assignee:
Battelle Memorial Institute (Richland, WA)
DOE Contract Number:  
AC05-76RL01830
Resource Type:
Patent
Resource Relation:
Patent File Date: 2012 Aug 15
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Zhang, Qibin, and Metz, Thomas O. Peptide and protein biomarkers for type 1 diabetes mellitus. United States: N. p., 2014. Web.
Zhang, Qibin, & Metz, Thomas O. Peptide and protein biomarkers for type 1 diabetes mellitus. United States.
Zhang, Qibin, and Metz, Thomas O. Tue . "Peptide and protein biomarkers for type 1 diabetes mellitus". United States. https://www.osti.gov/servlets/purl/1134213.
@article{osti_1134213,
title = {Peptide and protein biomarkers for type 1 diabetes mellitus},
author = {Zhang, Qibin and Metz, Thomas O.},
abstractNote = {A method for identifying persons with increased risk of developing type 1 diabetes mellitus, or having type I diabetes mellitus, utilizing selected biomarkers described herein either alone or in combination. The present disclosure allows for broad based, reliable, screening of large population bases. Also provided are arrays and kits that can be used to perform such methods.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {6}
}

Patent:

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Works referenced in this record:

An Inflammatory Gene-Expression Fingerprint in Monocytes of Autoimmune Thyroid Disease Patients
journal, April 2010

  • van der Heul-Nieuwenhuijsen, Leonie; Padmos, Roos C.; Drexhage, Roosmarijn C.
  • The Journal of Clinical Endocrinology & Metabolism, Vol. 95, Issue 4
  • DOI: 10.1210/jc.2009-1455

Proteomics and naturally occurring animal diseases: Opportunities for animal and human medicine
journal, February 2008

  • Doherty, Mary K.; Beynon, Robert J.; Whitfield, Phillip D.
  • PROTEOMICS – CLINICAL APPLICATIONS, Vol. 2, Issue 2
  • DOI: 10.1002/prca.200780085

Comparative aspects of diabetes mellitus in dogs and cats
journal, November 2002


The Pros and Cons of Diagnosing Diabetes With A1C
journal, April 2011

  • Bonora, E.; Tuomilehto, J.
  • Diabetes Care, Vol. 34, Issue Supplement_2
  • DOI: 10.2337/dc11-s216

Quantitative Mass Spectrometric Multiple Reaction Monitoring Assays for Major Plasma Proteins
journal, December 2005


Prediction of Autoantibody Positivity and Progression to Type 1 Diabetes: Diabetes Autoimmunity Study in the Young (DAISY)
journal, August 2004

  • Barker, Jennifer M.; Barriga, Katherine J.; Yu, Liping
  • The Journal of Clinical Endocrinology & Metabolism, Vol. 89, Issue 8
  • DOI: 10.1210/jc.2003-031887

Diabetes Antibody Standardization Program: First Assay Proficiency Evaluation
journal, May 2003


Measurement of islet cell antibodies in the Type 1 Diabetes Genetics Consortium: efforts to harmonize procedures among the laboratories
journal, July 2010

  • Bingley, Polly J.; Williams, Alistair JK; Colman, Peter G.
  • Clinical Trials: Journal of the Society for Clinical Trials, Vol. 7, Issue 1_suppl
  • DOI: 10.1177/1740774510373496

Plasma Gelsolin: Function, Prognostic Value, and Potential Therapeutic Use
journal, December 2008

  • Bucki, Robert; Levental, Ilya; Kulakowska, Alina
  • Current Protein & Peptide Science, Vol. 9, Issue 6
  • DOI: 10.2174/138920308786733912

Normalization Approaches for Removing Systematic Biases Associated with Mass Spectrometry and Label-Free Proteomics
journal, February 2006

  • Callister, Stephen J.; Barry, Richard C.; Adkins, Joshua N.
  • Journal of Proteome Research, Vol. 5, Issue 2
  • DOI: 10.1021/pr050300l

Biological activities of C1 inhibitor
journal, October 2008


Type 1 diabetes: entering the proteomic era
journal, April 2006

  • D’Hertog, Wannes; Mathieu, Chantal; Overbergh, Lut
  • Expert Review of Proteomics, Vol. 3, Issue 2
  • DOI: 10.1586/14789450.3.2.223

Development of a fibrinogen-specific sandwich enzyme-linked immunosorbent assay microarray assay for distinguishing between blood plasma and serum samples
journal, July 2011

  • Gonzalez, Rachel M.; Zhang, Qibin; Zangar, Richard C.
  • Analytical Biochemistry, Vol. 414, Issue 1, p. 99-102
  • DOI: 10.1016/j.ab.2011.02.039

The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants
journal, May 2011


Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.
journal, August 1988

  • Horn, G. T.; Bugawan, T. L.; Long, C. M.
  • Proceedings of the National Academy of Sciences, Vol. 85, Issue 16
  • DOI: 10.1073/pnas.85.16.6012

High-Abundance Polypeptides of the Human Plasma Proteome Comprising the Top 4 Logs of Polypeptide Abundance
journal, August 2008


Decon2LS: An open-source software package for automated processing and visualization of high resolution mass spectrometry data
journal, January 2009

  • Jaitly, Navdeep; Mayampurath, Anoop; Littlefield, Kyle
  • BMC Bioinformatics, Vol. 10, Issue 1
  • DOI: 10.1186/1471-2105-10-87

Environmental Triggers and Determinants of Type 1 Diabetes
journal, November 2005


Thrombocidins, Microbicidal Proteins from Human Blood Platelets, Are C-terminal Deletion Products of CXC Chemokines
journal, June 2000

  • Krijgsveld, Jeroen; Zaat, Sebastian A. J.; Meeldijk, Jan
  • Journal of Biological Chemistry, Vol. 275, Issue 27
  • DOI: 10.1074/jbc.275.27.20374

Multiple Reaction Monitoring-based, Multiplexed, Absolute Quantitation of 45 Proteins in Human Plasma
journal, May 2009


Potentiation of C1 Esterase Inhibitor by StcE, a Metalloprotease Secreted by Escherichia coli O157:H7
journal, April 2004

  • Lathem, Wyndham W.; Bergsbaken, Tessa; Welch, Rodney A.
  • The Journal of Experimental Medicine, Vol. 199, Issue 8
  • DOI: 10.1084/jem.20030255

Fully Automated Four-Column Capillary LC−MS System for Maximizing Throughput in Proteomic Analyses
journal, January 2008

  • Livesay, Eric A.; Tang, Keqi; Taylor, Beverley K.
  • Analytical Chemistry, Vol. 80, Issue 1
  • DOI: 10.1021/ac701727r

Effect of Collision Energy Optimization on the Measurement of Peptides by Selected Reaction Monitoring (SRM) Mass Spectrometry
journal, December 2010

  • MacLean, Brendan; Tomazela, Daniela M.; Abbatiello, Susan E.
  • Analytical Chemistry, Vol. 82, Issue 24
  • DOI: 10.1021/ac102179j

Application of Proteomics in the Discovery of Candidate Protein Biomarkers in a Diabetes Autoantibody Standardization Program Sample Subset
journal, February 2008

  • Metz, Thomas O.; Qian, Wei-Jun; Jacobs, Jon M.
  • Journal of Proteome Research, Vol. 7, Issue 2
  • DOI: 10.1021/pr700606w

VIPER: an advanced software package to support high-throughput LC-MS peptide identification
journal, June 2007


Interpretation of Shotgun Proteomic Data: The Protein Inference Problem
journal, July 2005


Improved Peptide Elution Time Prediction for Reversed-Phase Liquid Chromatography-MS by Incorporating Peptide Sequence Information
journal, July 2006

  • Petritis, Konstantinos; Kangas, Lars J.; Yan, Bo
  • Analytical Chemistry, Vol. 78, Issue 14
  • DOI: 10.1021/ac060143p

Primer: Immunity and Autoimmunity
journal, October 2008

  • Pietropaolo, M.; Surhigh, J. M.; Nelson, P. W.
  • Diabetes, Vol. 57, Issue 11
  • DOI: 10.2337/db07-1691

Enhanced Detection of Low Abundance Human Plasma Proteins Using a Tandem IgY12-SuperMix Immunoaffinity Separation Strategy
journal, July 2008

  • Qian, Wei-Jun; Kaleta, David T.; Petritis, Brianne O.
  • Molecular & Cellular Proteomics, Vol. 7, Issue 10
  • DOI: 10.1074/mcp.M800008-MCP200

Transthyretin constitutes a functional component in pancreatic β-cell stimulus-secretion coupling
journal, November 2005

  • Refai, E.; Dekki, N.; Yang, S.-N.
  • Proceedings of the National Academy of Sciences, Vol. 102, Issue 47, p. 17020-17025
  • DOI: 10.1073/pnas.0503219102

Targeted proteomic strategy for clinical biomarker discovery
journal, December 2008


Diabetes Antibody Standardization Program: evaluation of assays for insulin autoantibodies
journal, September 2010


Distinct Cerebrospinal Fluid Proteomes Differentiate Post-Treatment Lyme Disease from Chronic Fatigue Syndrome
journal, February 2011


Insulin-Dependent Diabetes Mellitus
journal, May 1996


The cation efflux transporter ZnT8 (Slc30A8) is a major autoantigen in human type 1 diabetes
journal, October 2007

  • Wenzlau, J. M.; Juhl, K.; Yu, L.
  • Proceedings of the National Academy of Sciences, Vol. 104, Issue 43, p. 17040-17045
  • DOI: 10.1073/pnas.0705894104

Prediction of Low-Energy Collision-Induced Dissociation Spectra of Peptides
journal, July 2004


Advances in proteomics data analysis and display using an accurate mass and time tag approach
journal, January 2006

  • Zimmer, Jennifer S. D.; Monroe, Matthew E.; Qian, Wei-Jun
  • Mass Spectrometry Reviews, Vol. 25, Issue 3
  • DOI: 10.1002/mas.20071