DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Mutations and genetic targets for enhanced L-tyrosine production

Abstract

The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine production, and bacterial strains capable of L-tyrosine production.

Inventors:
;
Issue Date:
Research Org.:
Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1132811
Patent Number(s):
8735132
Application Number:
13/101,579
Assignee:
Massachusetts Institute of Technology (Cambridge, MA)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12N - MICROORGANISMS OR ENZYMES
C - CHEMISTRY C12 - BIOCHEMISTRY C12P - FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {
DOE Contract Number:  
FC36-07GO17058
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 May 05
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Santos, Christine, and Stephanopoulos, Gregory. Mutations and genetic targets for enhanced L-tyrosine production. United States: N. p., 2014. Web.
Santos, Christine, & Stephanopoulos, Gregory. Mutations and genetic targets for enhanced L-tyrosine production. United States.
Santos, Christine, and Stephanopoulos, Gregory. Tue . "Mutations and genetic targets for enhanced L-tyrosine production". United States. https://www.osti.gov/servlets/purl/1132811.
@article{osti_1132811,
title = {Mutations and genetic targets for enhanced L-tyrosine production},
author = {Santos, Christine and Stephanopoulos, Gregory},
abstractNote = {The invention relates to identification of mutations and genetic targets for enhanced L-tyrosine production, and bacterial strains capable of L-tyrosine production.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 27 00:00:00 EDT 2014},
month = {Tue May 27 00:00:00 EDT 2014}
}

Works referenced in this record:

Strains for the Production of Flavonoids from Glucose
patent-application, February 2012


Conversion of a β-Ketoacyl Synthase to a Malonyl Decarboxylase by Replacement of the Active-Site Cysteine with Glutamine
journal, September 1999


Melamine Deaminase and Atrazine Chlorohydrolase: 98 Percent Identical but Functionally Different
journal, April 2001


Global transcription machinery engineering: A new approach for improving cellular phenotype
journal, May 2007


Tuning genetic control through promoter engineering
journal, August 2005


The regulation of bacterial transcription initiation
journal, January 2004


Gene expression profiling of Escherichia coli growth transitions: an expanded stringent response model
journal, July 2002


One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products
journal, May 2000


Production ofl-tryptophan,l-tyrosine and their analogues by use of immobilized tryptophanase and immobilizedβ-tyrosinase
journal, March 1975


DNA-binding determinants of the alpha subunit of RNA polymerase: novel DNA-binding domain architecture.
journal, January 1996


HDEA, a periplasmic protein that supports acid resistance in pathogenic enteric bacteria 1 1Edited by P. E. Wright
journal, January 2000


A genome-based approach to create a minimally mutated Corynebacterium glutamicum strain for efficient l-lysine production
journal, February 2006


The effect of intracellular ppGpp levels on glutamate and lysine overproduction in Escherichia coli
journal, September 2006


Functional Modulation of Escherichia Coli RNA Polymerase
journal, October 2000


Regulation of sigma factor competition by the alarmone ppGpp
journal, May 2002


Escherichia coli HdeB Is an Acid Stress Chaperone
journal, November 2006


Assessing the potential of mutational strategies to elicit new phenotypes in industrial strains
journal, February 2008


Mutagenesis of the Bacterial RNA Polymerase Alpha Subunit for Improvement of Complex Phenotypes
journal, February 2009


Engineering Central Metabolic Pathways for High-Level Flavonoid Production in Escherichia coli
journal, April 2007


Strain Improvement of Recombinant Escherichia coli for Efficient Production of Plant Flavonoids
journal, January 2008


Alpha-helical, but not beta-sheet, propensity of proline is determined by peptide environment.
journal, June 1996


A semi-quantitative high-throughput screening method for microbial l-tyrosine production in microtiter plates
journal, October 2007


L-Tyrosine production by deregulated strains of Escherichia coli
journal, January 2007


ppGpp: a global regulator in Escherichia coli
journal, May 2005


Multiple Sigma Subunits and the Partitioning of Bacterial Transcription Space
journal, October 2003


Solubilization of Protein Aggregates by the Acid Stress Chaperones HdeA and HdeB
journal, March 2008


Global Analysis of Genes Regulated by EvgA of the Two-Component Regulatory System in Escherichia coli
journal, April 2003


On the Structure of hisH: Protein Structure Prediction in the Context of Structural and Functional Genomics
journal, May 2001


Production of tyrosine from sucrose or glucose achieved by rapid genetic changes to phenylalanine-producing Escherichia coli strains
journal, January 2007


L-Tyrosine production by recombinant Escherichia coli : Fermentation optimization and recovery
journal, March 2008


DksA potentiates direct activation of amino acid promoters by ppGpp
journal, May 2005


High cell density cultivation of Escherichia coli at controlled specific growth rate
journal, August 1991


A third recognition element in bacterial promoters: DNA binding by the alpha subunit of RNA polymerase
journal, November 1993


Melanin-Based High-Throughput Screen for L-Tyrosine Production in Escherichia coli
journal, December 2007


Optimization of a heterologous pathway for the production of flavonoids from glucose
journal, July 2011


Basal ppGpp level adjustment shown by new spoT mutants affect steady state growth rates and rrnA ribosomal promoter regulation in Escherichia coli
journal, August 1988


Crystal structure of LacI member, PurR, bound to DNA: minor groove binding by alpha helices
journal, November 1994


Control of bacterial transcription, translation and replication by (p)ppGpp
journal, April 2008


Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency.
journal, November 1975


The global, ppGpp-mediated stringent response to amino acid starvation in Escherichia coli
journal, June 2008


Significance analysis of microarrays applied to the ionizing radiation response
journal, April 2001


Enzymic and nonenzymic transformations of chorismic acid and related cyclohexadienes
journal, October 1969


(p)ppGpp: Still Magical?
journal, October 2008