Microfluidic ultrasonic particle separators with engineered node locations and geometries
Abstract
An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Livermore National Laboratory (LLNL), Livermore, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1132523
- Patent Number(s):
- 8727129
- Application Number:
- 13/571,640
- Assignee:
- Lawrence Livermore National Security, LLC (Livermore, CA)
- Patent Classifications (CPCs):
-
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- DOE Contract Number:
- AC52-07NA27344
- Resource Type:
- Patent
- Resource Relation:
- Patent File Date: 2012 Aug 10
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 47 OTHER INSTRUMENTATION
Citation Formats
Rose, Klint A, Fisher, Karl A, Wajda, Douglas A, Mariella, Jr., Raymond P, Bailey, Christoppher, Dehlinger, Dietrich, Shusteff, Maxim, Jung, Byoungsok, and Ness, Kevin D. Microfluidic ultrasonic particle separators with engineered node locations and geometries. United States: N. p., 2014.
Web.
Rose, Klint A, Fisher, Karl A, Wajda, Douglas A, Mariella, Jr., Raymond P, Bailey, Christoppher, Dehlinger, Dietrich, Shusteff, Maxim, Jung, Byoungsok, & Ness, Kevin D. Microfluidic ultrasonic particle separators with engineered node locations and geometries. United States.
Rose, Klint A, Fisher, Karl A, Wajda, Douglas A, Mariella, Jr., Raymond P, Bailey, Christoppher, Dehlinger, Dietrich, Shusteff, Maxim, Jung, Byoungsok, and Ness, Kevin D. Tue .
"Microfluidic ultrasonic particle separators with engineered node locations and geometries". United States. https://www.osti.gov/servlets/purl/1132523.
@article{osti_1132523,
title = {Microfluidic ultrasonic particle separators with engineered node locations and geometries},
author = {Rose, Klint A and Fisher, Karl A and Wajda, Douglas A and Mariella, Jr., Raymond P and Bailey, Christoppher and Dehlinger, Dietrich and Shusteff, Maxim and Jung, Byoungsok and Ness, Kevin D},
abstractNote = {An ultrasonic microfluidic system includes a separation channel for conveying a sample fluid containing small particles and large particles, flowing substantially parallel, adjacent to a recovery fluid, with which it is in contact. An acoustic transducer produces an ultrasound standing wave, that generates a pressure field having at least one node of minimum pressure amplitude. An acoustic extension structure is located proximate to said separation channel for positioning said acoustic node off center in said acoustic area and concentrating the large particles in said recovery fluid stream.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {5}
}
Works referenced in this record:
Particle manipulation
patent, December 2001
- Coakley, William Terence; Hawkes, Jeremy John; Barrow, David
- US Patent Document 6,332,541
Method and device for separating particles
patent, March 2010
- Siversson, Carl
- US Patent Document 7,674,630
Component Separation Device
patent-application, May 2010
- Takahashi, Makoto; Nakatani, Masaya; Hiraoka, Soichiro
- US Patent Application 12/532908; 20100126922
Modeling the acoustic radiation force in microfluidic chambers
journal, April 2008
- Fisher, Karl A.; Miles, Robin
- The Journal of the Acoustical Society of America, Vol. 123, Issue 4
Micro-manipulation of small particles by node position control of an ultrasonic standing wave
journal, May 2002
- Haake, A.; Dual, J.
- Ultrasonics, Vol. 40, Issue 1-8, p. 317-322
Filtration of bacteria and yeast by ultrasound-enhanced sedimentation
journal, January 1997
- Hawkes, J. J.; Limaye, M. S.; Coakley, W. T.
- Journal of Applied Microbiology, Vol. 82, Issue 1
Multi-modal particle manipulator to enhance bead-based bioassays
journal, February 2010
- Glynne-Jones, P.; Boltryk, R. J.; Hill, M.
- Ultrasonics, Vol. 50, Issue 2, p. 235-239
Acoustic Particle Filter with Adjustable Effective Pore Size for Automated Sample Preparation
journal, November 2008
- Jung, Byoungsok; Fisher, Karl; Ness, Kevin D.
- Analytical Chemistry, Vol. 80, Issue 22
Chip integrated strategies for acoustic separation and manipulation of cells and particles
journal, January 2007
- Laurell, Thomas; Petersson, Filip; Nilsson, Andreas
- Chem. Soc. Rev., Vol. 36, Issue 3
Works referencing / citing this record:
Microfluidic ultrasonic particle separators with engineered node locations and geometries
patent, April 2016
- Rose, Klint A.; Fisher, Karl A.; Wajda, Douglas A.
- US Patent Document 9,321,050
Microfluidic ultrasonic particle separators with engineered node locations and geometries
patent, March 2015
- Rose, Klint A.; Fisher, Karl A.; Wajda, Douglas A.
- US Patent Document 8,991,614