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Title: Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents

The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1132075
Assignee:
Brookhaven Science Associates, LLC (Upton, NY) BNL
Patent Number(s):
8,729,012
Application Number:
12/995,919
Contract Number:
AC02-98CH10886
Resource Relation:
Patent File Date: 2009 Jun 02
Research Org:
Brookhaven National Laboratory (BNL), Upton, NY (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

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