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Title: Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents

Abstract

The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.

Inventors:
; ;
Issue Date:
Research Org.:
Brookhaven National Lab. (BNL), Upton, NY (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1132075
Patent Number(s):
8729012
Application Number:
12/995,919
Assignee:
Brookhaven Science Associates, LLC (Upton, NY)
Patent Classifications (CPCs):
C - CHEMISTRY C12 - BIOCHEMISTRY C12Q - MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC02-98CH10886
Resource Type:
Patent
Resource Relation:
Patent File Date: 2009 Jun 02
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

Citation Formats

Lee, Soo-Kwan, Gang, Oleg, and van der Lelie, Daniel. Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents. United States: N. p., 2014. Web.
Lee, Soo-Kwan, Gang, Oleg, & van der Lelie, Daniel. Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents. United States.
Lee, Soo-Kwan, Gang, Oleg, and van der Lelie, Daniel. Tue . "Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents". United States. https://www.osti.gov/servlets/purl/1132075.
@article{osti_1132075,
title = {Controllable assembly and disassembly of nanoparticle systems via protein and DNA agents},
author = {Lee, Soo-Kwan and Gang, Oleg and van der Lelie, Daniel},
abstractNote = {The invention relates to the use of peptides, proteins, and other oligomers to provide a means by which normally quenched nanoparticle fluorescence may be recovered upon detection of a target molecule. Further, the inventive technology provides a structure and method to carry out detection of target molecules without the need to label the target molecules before detection. In another aspect, a method for forming arbitrarily shaped two- and three-dimensional protein-mediated nanoparticle structures and the resulting structures are described. Proteins mediating structure formation may themselves be functionalized with a variety of useful moieties, including catalytic functional groups.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {5}
}

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