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Title: Luminescent macrocyclic lanthanide complexes

The present invention provides a novel class of macrocyclic compounds as well as complexes formed between a metal (e.g., lanthanide) ion and the compounds of the invention. Preferred complexes exhibit high stability as well as high quantum yields of lanthanide ion luminescence in aqueous media without the need for secondary activating agents. Preferred compounds incorporate hydroxy-isophthalamide moieties within their macrocyclic structure and are characterized by surprisingly low, non-specific binding to a variety of polypeptides such as antibodies and proteins as well as high kinetic stability. These characteristics distinguish them from known, open-structured ligands.
Inventors:
; ;
Issue Date:
OSTI Identifier:
1132073
Assignee:
The Regents of the University of California (Oakland, CA) OAK
Patent Number(s):
8,729,258
Application Number:
13/460,120
Contract Number:
AC03-76SF00098
Resource Relation:
Patent File Date: 2012 Apr 30
Research Org:
Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY

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