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Title: Solid state rapid thermocycling

The rapid thermal cycling of a material is targeted. A solid state heat exchanger with a first well and second well is coupled to a power module. A thermoelectric element is coupled to the first well, the second well, and the power module, is configured to transfer thermal energy from the first well to the second well when current from the power module flows through the thermoelectric element in a first direction, and is configured to transfer thermal energy from the second well to the first well when current from the power module flows through the thermoelectric element in a second direction. A controller may be coupled to the thermoelectric elements, and may switch the direction of current flowing through the thermoelectric element in response to a determination by sensors coupled to the wells that the amount of thermal energy in the wells falls below or exceeds a pre-determined threshold.
Inventors:
;
Issue Date:
OSTI Identifier:
1131403
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA) LLNL
Patent Number(s):
8,720,209
Application Number:
13/267,777
Contract Number:
AC52-07NA27344
Resource Relation:
Patent File Date: 2011 Oct 06
Research Org:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Other works cited in this record:

Sorting, amplification, detection, and identification of nucleic acid subsequences in a complex mixture
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On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets
journal, March 2008
  • Beer, N. Reginald; Wheeler, Elizabeth K.; Lee-Houghton, Lorenna
  • Analytical Chemistry, Vol. 80, Issue 6, p. 1854-1858
  • DOI: 10.1021/ac800048k

On-Chip, Real-Time, Single-Copy Polymerase Chain Reaction in Picoliter Droplets
journal, November 2007
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  • Analytical Chemistry, Vol. 79, Issue 22, p. 8471-8475
  • DOI: 10.1021/ac701809w

Kinetics of the DNA polymerase pyrococcus kodakaraensis
journal, June 2006
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  • Chemical Engineering Science, Vol. 61, Issue 12, p. 3885-3892
  • DOI: 10.1016/j.ces.2005.12.032

Nano/Microfluidics for diagnosis of infectious diseases in developing countries
journal, March 2010
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  • DOI: 10.1016/j.addr.2009.11.016

Rapid microfluidic thermal cycler for polymerase chain reaction nucleic acid amplification
journal, May 2008

Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends
journal, June 2007
  • Zhang, Chunsun; Xing, Da
  • Nucleic Acids Research, Vol. 35, Issue 13, p. 4223-4237
  • DOI: 10.1093/nar/gkm389

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