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Title: Solid state rapid thermocycling

Abstract

The rapid thermal cycling of a material is targeted. A solid state heat exchanger with a first well and second well is coupled to a power module. A thermoelectric element is coupled to the first well, the second well, and the power module, is configured to transfer thermal energy from the first well to the second well when current from the power module flows through the thermoelectric element in a first direction, and is configured to transfer thermal energy from the second well to the first well when current from the power module flows through the thermoelectric element in a second direction. A controller may be coupled to the thermoelectric elements, and may switch the direction of current flowing through the thermoelectric element in response to a determination by sensors coupled to the wells that the amount of thermal energy in the wells falls below or exceeds a pre-determined threshold.

Inventors:
;
Issue Date:
Research Org.:
Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1131403
Patent Number(s):
8720209
Application Number:
13/267,777
Assignee:
Lawrence Livermore National Security, LLC (Livermore, CA)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01L - CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
C - CHEMISTRY C12 - BIOCHEMISTRY C12M - APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
DOE Contract Number:  
AC52-07NA27344
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Oct 06
Country of Publication:
United States
Language:
English
Subject:
36 MATERIALS SCIENCE

Citation Formats

Beer, Neil Reginald, and Spadaccini, Christopher. Solid state rapid thermocycling. United States: N. p., 2014. Web.
Beer, Neil Reginald, & Spadaccini, Christopher. Solid state rapid thermocycling. United States.
Beer, Neil Reginald, and Spadaccini, Christopher. Tue . "Solid state rapid thermocycling". United States. https://www.osti.gov/servlets/purl/1131403.
@article{osti_1131403,
title = {Solid state rapid thermocycling},
author = {Beer, Neil Reginald and Spadaccini, Christopher},
abstractNote = {The rapid thermal cycling of a material is targeted. A solid state heat exchanger with a first well and second well is coupled to a power module. A thermoelectric element is coupled to the first well, the second well, and the power module, is configured to transfer thermal energy from the first well to the second well when current from the power module flows through the thermoelectric element in a first direction, and is configured to transfer thermal energy from the second well to the first well when current from the power module flows through the thermoelectric element in a second direction. A controller may be coupled to the thermoelectric elements, and may switch the direction of current flowing through the thermoelectric element in response to a determination by sensors coupled to the wells that the amount of thermal energy in the wells falls below or exceeds a pre-determined threshold.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {5}
}

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Works referenced in this record:

On-Chip Single-Copy Real-Time Reverse-Transcription PCR in Isolated Picoliter Droplets
journal, March 2008


On-Chip, Real-Time, Single-Copy Polymerase Chain Reaction in Picoliter Droplets
journal, November 2007


Kinetics of the DNA polymerase pyrococcus kodakaraensis
journal, June 2006


Isothermal surface production and regulation for high heat flux applications utilizing porous inserts
journal, August 2001


Performance evaluation of thermal cyclers for PCR in a rapid cycling condition
journal, April 2008


High-Throughput Quantitative Polymerase Chain Reaction in Picoliter Droplets
journal, December 2008


A Novel Coronavirus Associated with Severe Acute Respiratory Syndrome
journal, May 2003


Nano/Microfluidics for diagnosis of infectious diseases in developing countries
journal, March 2010


Rapid microfluidic thermal cycler for polymerase chain reaction nucleic acid amplification
journal, May 2008


Thermal management in microfluidics using micro-Peltier junctions
journal, October 2005


Ultra fast miniaturized real-time PCR: 40 cycles in less than six minutes
journal, June 2006


Development of a High-Speed Real-Time Polymerase Chain Reaction System Using a Circulating Water-Based Rapid Heat-Exchange
journal, June 2010


Microdroplet-based PCR enrichment for large-scale targeted sequencing
journal, November 2009


A novel strategy to engineer DNA polymerases for enhanced processivity and improved performance in vitro
journal, February 2004


Miniaturized PCR chips for nucleic acid amplification and analysis: latest advances and future trends
journal, June 2007