skip to main content
DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method of detecting luminescent target ions with modified magnetic microspheres

Abstract

This invention provides methods of using modified magnetic microspheres to extract target ions from a sample in order to detect their presence in a microfluidic environment. In one or more embodiments, the microspheres are modified with molecules on the surface that allow the target ions in the sample to form complexes with specific ligand molecules on the microsphere surface. In one or more embodiments, the microspheres are modified with molecules that sequester the target ions from the sample, but specific ligand molecules in solution subsequently re-extract the target ions from the microspheres into the solution, where the complexes form independent of the microsphere surface. Once the complexes form, they are exposed to an excitation wavelength light source suitable for exciting the target ion to emit a luminescent signal pattern. Detection of the luminescent signal pattern allows for determination of the presence of the target ions in the sample.

Inventors:
;
Issue Date:
Research Org.:
Argonne National Lab. (ANL), Argonne, IL (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1131022
Patent Number(s):
8,722,415
Application Number:
13/038,673
Assignee:
U.S. Department of Energy (Washington, DC)
DOE Contract Number:  
AC02-06CH11357
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 Mar 02
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Shkrob, Ilya A, and Kaminski, Michael D. Method of detecting luminescent target ions with modified magnetic microspheres. United States: N. p., 2014. Web.
Shkrob, Ilya A, & Kaminski, Michael D. Method of detecting luminescent target ions with modified magnetic microspheres. United States.
Shkrob, Ilya A, and Kaminski, Michael D. Tue . "Method of detecting luminescent target ions with modified magnetic microspheres". United States. https://www.osti.gov/servlets/purl/1131022.
@article{osti_1131022,
title = {Method of detecting luminescent target ions with modified magnetic microspheres},
author = {Shkrob, Ilya A and Kaminski, Michael D},
abstractNote = {This invention provides methods of using modified magnetic microspheres to extract target ions from a sample in order to detect their presence in a microfluidic environment. In one or more embodiments, the microspheres are modified with molecules on the surface that allow the target ions in the sample to form complexes with specific ligand molecules on the microsphere surface. In one or more embodiments, the microspheres are modified with molecules that sequester the target ions from the sample, but specific ligand molecules in solution subsequently re-extract the target ions from the microspheres into the solution, where the complexes form independent of the microsphere surface. Once the complexes form, they are exposed to an excitation wavelength light source suitable for exciting the target ion to emit a luminescent signal pattern. Detection of the luminescent signal pattern allows for determination of the presence of the target ions in the sample.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {5}
}

Patent:

Save / Share:

Works referenced in this record: