Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1

Culiat, Cymbeline T

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Title: Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1

Abstract

It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.

Inventors:: Culiat, Cymbeline T

Issue Date:: 2014-05-13

Research Org.:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Org.:: USDOE

OSTI Identifier:: 1131020

Patent Number(s):: 8722625

Application Number:: 12/284,667

Assignee:: UT-Battelle, LLC (Oak Ridge, TN)

Patent Classifications (CPCs):: A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

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A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61K - PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
A61K31/7088 - Compounds having three or more nucleosides or nucleotides
A61K35/34 - Muscles
A61K38/18 - Growth factors
A61K38/1875 - {Bone morphogenic factor

A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
A61P9/00 - Drugs for disorders of the cardiovascular system
A61P9/04 - Inotropic agents, i.e. stimulants of cardiac contraction
A61P9/10 - for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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DOE Contract Number:: AC05-000R22725

Resource Type:: Patent

Country of Publication:: United States

Language:: English

Subject:: 60 APPLIED LIFE SCIENCES

Citation Formats


                    Culiat, Cymbeline T. Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1.  United States: N. p., 2014. 
        Web.

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                    Culiat, Cymbeline T. Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1.  United States.

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                    Culiat, Cymbeline T. Tue .  
        "Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1".  United States.  https://www.osti.gov/servlets/purl/1131020.

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@article{osti_1131020,

  title        = {Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1},

  author       = {Culiat, Cymbeline T},

  abstractNote = {It has been identified in accordance with the present invention that Nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a Nell1 protein or nucleic acid molecule.},

  doi          = {},

  journal      = {},
number       = ,

  volume       = ,

  place        = {United States},

  year         = {2014},

  month        = {5}

}

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Works referenced in this record:

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Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
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Nfatc2 is a primary response gene of nell-1 regulating chondrogenesis in ATDC5 cells
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Chen, Weiwei; Zhang, Xinli; Siu, Ronald K.
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Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
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Maeda, Kenji; Matsuhashi, Sachiko; Tabuchi, Kazuo
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Composition for cartilage
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Ting, Kang; Wu, Ben; Soo, Chia
US Patent Application 11/594510; 20070134291
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Nell-1 induced bone formation within the distracted intermaxillary suture
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NELL-1 enhanced bone mineralization
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Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
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Cranial and vertebral defects associated with loss-of-function of Nell
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A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
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Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
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Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
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Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
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Nell-1-Induced Bone Regeneration in Calvarial Defects
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Aghaloo, Tara; Cowan, Catherine M.; Chou, Yu-Fen
The American Journal of Pathology, Vol. 169, Issue 3, p. 903-915
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Similar Records

Title: Treatment of cardiovascular disorders using the cell differentiation signaling protein Nell1

Abstract

Citation Formats

Nell peptide expression systems and bone formation activity of nell peptide patent-application, December 2006

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects journal, March 2006

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide patent-application, September 2011

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats journal, December 1996

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15 journal, January 2002

Cell-Based Approaches for Cardiac Repair journal, October 2006

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts journal, March 2007

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD) journal, June 2004

Nfatc2 is a primary response gene of nell-1 regulating chondrogenesis in ATDC5 cells journal, May 2011

Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1 patent, March 2011

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors journal, January 2001

Bone marrow cells for cardiac regeneration and repair: current status and issues journal, July 2006

The osteoinductive properties of Nell-1 in a rat spinal fusion model journal, January 2007

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene journal, August 2007

Effect of Nell-1 Delivery on Chondrocyte Proliferation and Cartilaginous Extracellular Matrix Deposition journal, May 2010

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage journal, April 1999

Composition for cartilage patent-application, June 2007

Nell-1 induced bone formation within the distracted intermaxillary suture journal, January 2006

NELL-1 enhanced bone mineralization patent, May 2006

Nell-1 enhanced bone mineralization patent-application, May 2006

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development journal, May 2006

Cranial and vertebral defects associated with loss-of-function of Nell patent-application, March 2006

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation journal, October 2007

Human NELL-1 Expressed in Unilateral Coronal Synostosis journal, January 1999

NELL-1 enhanced bone mineralization patent-application, October 2006

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2 journal, November 1999

From cardiac repair to cardiac regeneration – ready to translate? journal, August 2006

Growth Factor Enhancement of Cardiac Regeneration journal, January 2006

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C journal, November 1999

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development journal, December 2003

Adenovirus vectors encoding brain natriuretic peptide patent-application, February 2006

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice journal, June 2001

Nell-1-Induced Bone Regeneration in Calvarial Defects journal, September 2006

Nell peptide expression systems and bone formation activity of nell peptide
patent-application, December 2006

Nell1-deficient mice have reduced expression of extracellular matrix proteins causing cranial and vertebral defects
journal, March 2006

Method to Treat or Prevent a Skin Condition Using a Nell 1 Peptide
patent-application, September 2011

Cloning and Characterization of Two Novel Human cDNAs (NELL1 and NELL2) Encoding Proteins with Six EGF-like Repeats
journal, December 1996

Functional annotation of mammalian genomic DNA sequence by chemical mutagenesis: A fine-structure genetic mutation map of a 1- to 2-cM segment of mouse chromosome 7 corresponding to human chromosome 11p14-p15
journal, January 2002

Cell-Based Approaches for Cardiac Repair
journal, October 2006

Synergistic Effects of Nell-1 and BMP-2 on the Osteogenic Differentiation of Myoblasts
journal, March 2007

The Novel Gene Encoding a Putative Transmembrane Protein Is Mutated in Gnathodiaphyseal Dysplasia (GDD)
journal, June 2004

Nfatc2 is a primary response gene of nell-1 regulating chondrogenesis in ATDC5 cells
journal, May 2011

Methods for promoting wound healing and muscle regeneration with the cell signaling protein Nell1
patent, March 2011

Brain Specific Human Genes, NELL1 and NELL2, Are Predominantly Expressed in Neuroblastoma and Other Embryonal Neuroepithelial Tumors
journal, January 2001

Bone marrow cells for cardiac regeneration and repair: current status and issues
journal, July 2006

The osteoinductive properties of Nell-1 in a rat spinal fusion model
journal, January 2007

Systematic Association Mapping Identifies NELL1 as a Novel IBD Disease Gene
journal, August 2007

Effect of Nell-1 Delivery on Chondrocyte Proliferation and Cartilaginous Extracellular Matrix Deposition
journal, May 2010

The neuronal EGF-related genes NELL1 and NELL2 are expressed in hemopoietic cells and developmentally regulated in the B lineage
journal, April 1999

Composition for cartilage
patent-application, June 2007

Nell-1 induced bone formation within the distracted intermaxillary suture
journal, January 2006

NELL-1 enhanced bone mineralization
patent, May 2006

Nell-1 enhanced bone mineralization
patent-application, May 2006

Nell-1 induces acrania-like cranioskeletal deformities during mouse embryonic development
journal, May 2006

Cranial and vertebral defects associated with loss-of-function of Nell
patent-application, March 2006

A Study of the Role of Nell-1 Gene Modified Goat Bone Marrow Stromal Cells in Promoting New Bone Formation
journal, October 2007

Human NELL-1 Expressed in Unilateral Coronal Synostosis
journal, January 1999

NELL-1 enhanced bone mineralization
patent-application, October 2006

Biochemical Characterization and Expression Analysis of Neural Thrombospondin-1-like Proteins NELL1 and NELL2
journal, November 1999

From cardiac repair to cardiac regeneration – ready to translate?
journal, August 2006

Growth Factor Enhancement of Cardiac Regeneration
journal, January 2006

Involvement of Epidermal Growth Factor-like Domain of NELL Proteins in the Novel Protein–Protein Interaction with Protein Kinase C
journal, November 1999

Overexpression of Nell-1, a Craniosynostosis-Associated Gene, Induces Apoptosis in Osteoblasts During Craniofacial Development
journal, December 2003

Adenovirus vectors encoding brain natriuretic peptide
patent-application, February 2006

Transplanted Adult Bone Marrow Cells Repair Myocardial Infarcts in Mice
journal, June 2001

Nell-1-Induced Bone Regeneration in Calvarial Defects
journal, September 2006