Modulation of Rhamm (CD168) for selective adipose tissue development
Abstract
Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.
- Inventors:
- Issue Date:
- Research Org.:
- Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States)
- Sponsoring Org.:
- USDOE
- OSTI Identifier:
- 1130537
- Patent Number(s):
- 8715653
- Application Number:
- 12/515,405
- Assignee:
- The Regents of the University of California (Oakland, CA)
- Patent Classifications (CPCs):
-
A - HUMAN NECESSITIES A61 - MEDICAL OR VETERINARY SCIENCE A61P - SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
C - CHEMISTRY C07 - ORGANIC CHEMISTRY C07K - PEPTIDES
- DOE Contract Number:
- AC02-05CH11231
- Resource Type:
- Patent
- Country of Publication:
- United States
- Language:
- English
- Subject:
- 60 APPLIED LIFE SCIENCES
Citation Formats
Turley, Eva A, and Bissell, Mina J. Modulation of Rhamm (CD168) for selective adipose tissue development. United States: N. p., 2014.
Web.
Turley, Eva A, & Bissell, Mina J. Modulation of Rhamm (CD168) for selective adipose tissue development. United States.
Turley, Eva A, and Bissell, Mina J. Tue .
"Modulation of Rhamm (CD168) for selective adipose tissue development". United States. https://www.osti.gov/servlets/purl/1130537.
@article{osti_1130537,
title = {Modulation of Rhamm (CD168) for selective adipose tissue development},
author = {Turley, Eva A and Bissell, Mina J},
abstractNote = {Herein is described the methods and compositions for modulation of Rhamm, also known as CD 186, and its effects on wound repair, muscle differentiation, bone density and adipogeneisis through its ability to regulate mesenchymal stem cell differentiation. Compositions and methods are provided for blocking Rhamm function for selectively increasing subcutaneous, but not, visceral fat. Compositions and methods for modulating Rhamm in wound repair are also described.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {Tue May 06 00:00:00 EDT 2014},
month = {Tue May 06 00:00:00 EDT 2014}
}
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Works referenced in this record:
Anti-tnfα therapy is useful in rheumatoid arthritis and crohn’s disease: analysis of the mechanism of action predicts utility in other diseases
journal, December 1998
- Feldman, M.; Taylor, P.; Paleolog, E.
- Transplantation Proceedings, Vol. 30, Issue 8
Signaling Properties of Hyaluronan Receptors
journal, February 2002
- Turley, Eva A.; Noble, Paul W.; Bourguignon, Lilly Y. W.
- Journal of Biological Chemistry, Vol. 277, Issue 7
Hyaluronan: from extracellular glue to pericellular cue
journal, July 2004
- Toole, Bryan P.
- Nature Reviews Cancer, Vol. 4, Issue 7
Of Mice and Not Men: Differences between Mouse and Human Immunology
journal, February 2004
- Mestas, Javier; Hughes, Christopher C. W.
- The Journal of Immunology, Vol. 172, Issue 5
Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility
journal, June 1992
- Hardwick, C.; Hoare, K.; Owens, R.
- Journal of Cell Biology, Vol. 117, Issue 6
MAP kinases and cell migration
journal, September 2004
- Huang, Cai; Jacobson, Ken; Schaller, Michael D.
- Journal of Cell Science, Vol. 117, Issue 20
Rhamm Peptide Conjugates
patent-application, February 2004
- Woloski, B. Micahel R.; Williams, Ashely Martin; Sereda, Terrance Jimmy
- US Patent Application 10/257377; 20040037834
CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity
journal, September 1997
- Schmits, Rudolf; Filmus, Jorge; Gerwin, Nicole
- Blood, Vol. 90, Issue 6
The Hyaluronan Receptor RHAMM Regulates Extracellular-regulated Kinase
journal, May 1998
- Zhang, Shiwen; Chang, Michael C. Y.; Zylka, Danuta
- Journal of Biological Chemistry, Vol. 273, Issue 18
The future of wound healing: Pursuing surgical models in transgenic and knockout mice
journal, October 2004
- Reid, Russell R.; Said, Hakim K.; Mogford, Jon E.
- Journal of the American College of Surgeons, Vol. 199, Issue 4
RHAMM/CD168-R3 Peptide Vaccination of HLA-A2+ Patients with Acute Myeloid Leukemia (AML), Myelodysplastic Syndrome (MDS) and Multiple Myeloma (MM).
journal, November 2005
- Greiner, Jochen; Giannopoulos, Krzysztof; Li, Li
- Blood, Vol. 106, Issue 11
RHAMM, a receptor for hyaluronan-mediated motility, compensates for CD44 in inflamed CD44-knockout mice: A different interpretation of redundancy
journal, December 2004
- Nedvetzki, S.; Gonen, E.; Assayag, N.
- Proceedings of the National Academy of Sciences, Vol. 101, Issue 52
TGF-beta 1 stimulation of cell locomotion utilizes the hyaluronan receptor RHAMM and hyaluronan.
journal, November 1993
- Samuel, S. K.; Hurta, R. A.; Spearman, M. A.
- Journal of Cell Biology, Vol. 123, Issue 3
Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor)
journal, October 2003
- Tolg, Cornelia; Poon, Raymoond; Fodde, Riccardo
- Oncogene, Vol. 22, Issue 44
Rhamm−/− fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repair
journal, December 2006
- Tolg, Cornelia; Hamilton, Sara R.; Nakrieko, Kerry-Ann
- Journal of Cell Biology, Vol. 175, Issue 6
PAI-1 expression is required for epithelial cell migration in two distinct phases of in vitro wound repair
journal, January 2004
- Providence, Kirwin M.; Higgins, Paul J.
- Journal of Cellular Physiology, Vol. 200, Issue 2
Compositions and Methods for Treating Cellular Response to Injury and Other Proliferating Cell Disorders Regulated by Hyaladherin and Hyalurons
patent-application, March 2005
- Turley, Eva A.; Cruz, Tony F.
- US Patent Application 10/898675; 20050058646
Adult bone-marrow-derived mesenchymal stem cells contribute to wound healing of skin appendages
journal, August 2006
- Li, Haihong; Fu, Xiaobing; Ouyang, Yunshu
- Cell and Tissue Research, Vol. 326, Issue 3
Stretch-induced bladder smooth muscle cell (SMC) proliferation is mediated by RHAMM-dependent extracellular-regulated kinase (erk) signaling
journal, June 2001
- Aitken, K.; Bägl, D. J.
- Urology, Vol. 57, Issue 6
Methods and compositions for inhibition of multi-drug resistance by hyaluronan oligomers
patent, January 2012
- Toole, Bryan P.; Misra, Suniti; Ghatak, Shibnath
- US Patent Document 8,093,217
Hyaluronan and Homeostasis: A Balancing Act
journal, February 2002
- Tammi, Markku I.; Day, Anthony J.; Turley, Eva A.
- Journal of Biological Chemistry, Vol. 277, Issue 7
Overexpression of the hyaluronan receptor RHAMM is transforming and is also required for H-ras transformation
journal, July 1995
- Hall, Christine L.; Yang, Baihua; Yang, Xuiwei
- Cell, Vol. 82, Issue 1
Chronic liver injury, TGF-β, and cancer
journal, December 2001
- Bissell, D. Montgomery
- Experimental & Molecular Medicine, Vol. 33, Issue 4
Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.
journal, April 1997
- Kaya, G.; Rodriguez, I.; Jorcano, J. L.
- Genes & Development, Vol. 11, Issue 8
Paracrine Regulation of Angiogenesis and Adipocyte Differentiation During In Vivo Adipogenesis
journal, October 2003
- Fukumura, Dai; Ushiyama, Akira; Duda, Dan G.
- Circulation Research, Vol. 93, Issue 9
Unconventional Secretory Routes: Direct Protein Export Across the Plasma Membrane of Mammalian Cells
journal, August 2005
- Nickel, Walter
- Traffic, Vol. 6, Issue 8
RHAMM Antagonist Antibodies
patent-application, September 2002
- Holmes, Stephen D.; Abrahamson, Julie A.; Jackson, Jeffrey R.
- US Patent Application 10/140555; 20020127227
Fibroblasts require protein kinase C activation to respond to hyaluronan with increased locomotion
journal, June 2001
- Hall, Christine L.; Collis, Lisa A.; Bo A., Jing
- Matrix Biology, Vol. 20, Issue 3
Migration of bovine aortic smooth muscle cells after wounding injury. The role of hyaluronan and RHAMM.
journal, March 1995
- Savani, R. C.; Wang, C.; Yang, B.
- Journal of Clinical Investigation, Vol. 95, Issue 3
Hyaluronan and Hyaluronan Synthases: Potential Therapeutic Targets in Cancer
journal, February 2005
- Adamia, Sophia; Maxwell, Christopher; Pilarski, Linda
- Current Drug Target -Cardiovascular & Hematological Disorders, Vol. 5, Issue 1
Enhanced wound-healing quality with bone marrow mesenchymal stem cells autografting after skin injury: Enhancing wound healing with stem cells
journal, May 2006
- Fu, Xiaobing; Fang, Lijun; Li, Xiaokun
- Wound Repair and Regeneration, Vol. 14, Issue 3
Bloodstream Cells Phenotypically Identical to Human Mesenchymal Bone Marrow Stem Cells Circulate in Large Amounts Under the Influence of Acute Large Skin Damage: New Evidence for Their Use in Regenerative Medicine
journal, April 2006
- Mansilla, E.; Marı́n, G. H.; Drago, H.
- Transplantation Proceedings, Vol. 38, Issue 3
Mesenchymal Bone Marrow Stem Cells More Effectively Stimulate Regeneration of Deep Burn Wounds than Embryonic Fibroblasts
journal, January 2003
- Shumakov, V. I.; Onishchenko, N. A.; Rasulov, M. F.
- Bulletin of Experimental Biology and Medicine, Vol. 136, Issue 2, p. 192-195
Receptor for hyaluronan-mediated motility (RHAMM), a hyaladherin that regulates cell responses to growth factors
journal, February 1999
- Cheung, W. -F.; Cruz, T. F.; Turley, E. A.
- Biochemical Society Transactions, Vol. 27, Issue 2
The influence of the microenvironment on the malignant phenotype
journal, August 2000
- Park, Catherine C.; Bissell, Mina J.; Barcellos-Hoff, Mary Helen
- Molecular Medicine Today, Vol. 6, Issue 8
Hyaluronan receptor expression increases in fetal excisional skin wounds and correlates with fibroplasia
journal, July 1998
- Lovvorn, Harold N.; Cass, Darrell L.; Sylvester, Karl G.
- Journal of Pediatric Surgery, Vol. 33, Issue 7
Tumor-associated Antigen RHAMM
patent-application, September 2003
- Schmitt, Michael; Greiner, Jochen
- US Patent Application 10/256250; 20030170755
Rhamm, a Co-receptor and Its Interactions with Other Receptors in Cancer Cell Motility and the Identification of Cancer Prognitor Cell Populations
patent-application, March 2010
- Turley, Eva A.; Bissell, Mina J.; Winnik, Francoise
- US Patent Application 12/470453; 20100062000
Purification of a hyaluronate-binding protein fraction that modifies cell social behavior
journal, October 1982
- Turley, E. A.
- Biochemical and Biophysical Research Communications, Vol. 108, Issue 3
Modulation of Rhamm-Caveolin/lipid Raft Interactions to Affect Development, Responses to Tissue Injury, Angiogenesis, Tumorigenesis, Metastasis and Growth Factor/cytokine Responses
patent-application, August 2007
- Savani, Rashmin C.
- US Patent Application 11/458990; 20070179085
-Catenin stabilization dysregulates mesenchymal cell proliferation, motility, and invasiveness and causes aggressive fibromatosis and hyperplastic cutaneous wounds
journal, April 2002
- Cheon, S. S.; Cheah, A. Y. L.; Turley, S.
- Proceedings of the National Academy of Sciences, Vol. 99, Issue 10
Compositions and Methods for Treating Cellular Response to Injury and Other Proliferating Cell Disorders Regulated by Hyaladherin and Hyaluronans
patent-application, May 2003
- Cruz, Tony; Pastrak, Aleksandra; Turley, Eva A.
- US Patent Application 09/978309; 20030100490