DOE Patents title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Dielectrokinetic chromatography and devices thereof

Abstract

Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.

Inventors:
; ;
Issue Date:
Research Org.:
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1129393
Patent Number(s):
8702946
Application Number:
12/128,913
Assignee:
Sandia Corporation (Albuquerque, NM)
Patent Classifications (CPCs):
B - PERFORMING OPERATIONS B01 - PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL B01D - SEPARATION
G - PHYSICS G01 - MEASURING G01N - INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
DOE Contract Number:  
AC04-94AL85000
Resource Type:
Patent
Resource Relation:
Patent File Date: 2008 May 29
Country of Publication:
United States
Language:
English
Subject:
47 OTHER INSTRUMENTATION

Citation Formats

Chirica, Gabriela S, Fiechtner, Gregory J, and Singh, Anup K. Dielectrokinetic chromatography and devices thereof. United States: N. p., 2014. Web.
Chirica, Gabriela S, Fiechtner, Gregory J, & Singh, Anup K. Dielectrokinetic chromatography and devices thereof. United States.
Chirica, Gabriela S, Fiechtner, Gregory J, and Singh, Anup K. Tue . "Dielectrokinetic chromatography and devices thereof". United States. https://www.osti.gov/servlets/purl/1129393.
@article{osti_1129393,
title = {Dielectrokinetic chromatography and devices thereof},
author = {Chirica, Gabriela S and Fiechtner, Gregory J and Singh, Anup K},
abstractNote = {Disclosed herein are methods and devices for dielectrokinetic chromatography. As disclosed, the devices comprise microchannels having at least one perturber which produces a non-uniformity in a field spanning the width of the microchannel. The interaction of the field non-uniformity with a perturber produces a secondary flow which competes with a primary flow. By decreasing the size of the perturber the secondary flow becomes significant for particles/analytes in the nanometer-size range. Depending on the nature of a particle/analyte present in the fluid and its interaction with the primary flow and the secondary flow, the analyte may be retained or redirected. The composition of the primary flow can be varied to affect the magnitude of primary and/or secondary flows on the particles/analytes and thereby separate and concentrate it from other particles/analytes.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {4}
}

Works referenced in this record:

Polyether-polycarbonates for dialysis membranes
patent, January 1986


Microlithographic array for macromolecule and cell fractionation
patent, June 1995


Electrokinetic concentration of charged molecules
patent, August 2002


Device and method for the manipulation of a fluid sample
patent-application, November 2002


Continuous flow dielectrophoretic particle concentrator
patent-application, January 2003


Acute treatment of headache with phenothiazine antipsychotics
patent-application, May 2004


Method for continuous particle separation using obstacle arrays asymmetrically aligned to fields
patent-application, July 2004


Frit material and bonding method for microfluidic separation devices
patent-application, January 2005


Microfluidic devices comprising biochannels
patent-application, January 2005


Microliter scale solid phase extraction devices
patent-application, July 2006


Cell separation method using hydrophobic solid supports
patent-application, October 2006


Coherent nonlinear chromatography and methods and devices thereof
patent-application, April 2007


Coupling for conduits sealed in a recess of a housing
patent-application, June 2007


Planar quartz chips with submicron channels for two-dimensional capillary electrophoresis applications
journal, March 1998


Planar dielectrochromatography on non-wetted thin layers
journal, August 2001


Dielectrophoretic chromatography with cross-flow injection
conference, January 2002

  • Sano, H.; Kabata, H.; Kurosawa, O.
  • Technical Digest. MEMS 2002 IEEE International Conference. Fifteenth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.02CH37266)
  • https://doi.org/10.1109/MEMSYS.2002.984043

CdSe nanowires with illumination-enhanced conductivity: Induced dipoles, dielectrophoretic assembly, and field-sensitive emission
journal, April 2007


High-intensity, high-gradient electric separation and dielectric filtration of particulate and granular materials
journal, December 1982


Sorting by diffusion: An asymmetric obstacle course for continuous molecular separation
journal, November 1999


Separating Microbes in the Manner of Molecules. 1. Capillary Electrokinetic Approaches
journal, December 1999


Electrochromatography in Microchips:  Reversed-Phase Separation of Peptides and Amino Acids Using Photopatterned Rigid Polymer Monoliths
journal, February 2002


A DNA prism for high-speed continuous fractionation of large DNA molecules
journal, September 2002


Dielectrophoretic filter for separation and recovery of biological cells in water
journal, September 2003


Electroporation of Mammalian Cells in a Microfluidic Channel with Geometric Variation
journal, July 2006


Dielectrophoresis in Microchips Containing Arrays of Insulating Posts:  Theoretical and Experimental Results
journal, September 2003


Insulator-based dielectrophoresis for the selective concentration and separation of live bacteria in water
journal, June 2004


Dielectrophoretic Concentration and Separation of Live and Dead Bacteria in an Array of Insulators
journal, March 2004


Streaming dielectrophoresis for continuous-flow microfluidic devices
journal, November 2003


Microfluidic Cell Separation by 2-dimensional Dielectrophoresis
journal, January 1999


    Works referencing / citing this record:

    Dielectrokinetic chromatography devices
    patent, December 2014