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Title: Orthogonal ion injection apparatus and process

Abstract

An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions.

Inventors:
;
Issue Date:
Research Org.:
Pacific Northwest National Lab. (PNNL), Richland, WA (United States)
Sponsoring Org.:
USDOE
OSTI Identifier:
1129193
Patent Number(s):
8,698,075
Application Number:
13/114,869
Assignee:
Battelle Memorial Institute (Richland, WA) PNNL
DOE Contract Number:  
AC05-76RLO1830
Resource Type:
Patent
Resource Relation:
Patent File Date: 2011 May 24
Country of Publication:
United States
Language:
English
Subject:
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND TECHNOLOGY

Citation Formats

Kurulugama, Ruwan T, and Belov, Mikhail E. Orthogonal ion injection apparatus and process. United States: N. p., 2014. Web.
Kurulugama, Ruwan T, & Belov, Mikhail E. Orthogonal ion injection apparatus and process. United States.
Kurulugama, Ruwan T, and Belov, Mikhail E. Tue . "Orthogonal ion injection apparatus and process". United States. https://www.osti.gov/servlets/purl/1129193.
@article{osti_1129193,
title = {Orthogonal ion injection apparatus and process},
author = {Kurulugama, Ruwan T and Belov, Mikhail E},
abstractNote = {An orthogonal ion injection apparatus and process are described in which ions are directly injected into an ion guide orthogonal to the ion guide axis through an inlet opening located on a side of the ion guide. The end of the heated capillary is placed inside the ion guide such that the ions are directly injected into DC and RF fields inside the ion guide, which efficiently confines ions inside the ion guide. Liquid droplets created by the ionization source that are carried through the capillary into the ion guide are removed from the ion guide by a strong directional gas flow through an inlet opening on the opposite side of the ion guide. Strong DC and RF fields divert ions into the ion guide. In-guide orthogonal injection yields a noise level that is a factor of 1.5 to 2 lower than conventional inline injection known in the art. Signal intensities for low m/z ions are greater compared to convention inline injection under the same processing conditions.},
doi = {},
journal = {},
number = ,
volume = ,
place = {United States},
year = {2014},
month = {4}
}

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Works referenced in this record:

The ion funnel: Theory, implementations, and applications
journal, April 2009

  • Kelly, Ryan T.; Tolmachev, Aleksey V.; Page, Jason S.
  • Mass Spectrometry Reviews, Vol. 29, Issue 2, p. 294-312
  • DOI: 10.1002/mas.20232