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Title: Nucleic acid encoding a self-assembling split-fluorescent protein system

The invention provides a protein labeling and detection system based on self-complementing fragments of fluorescent and chromophoric proteins. The system of the invention is exemplified with various combinations of self-complementing fragments derived from Aequorea victoria Green Fluorescent Protein (GFP), which are used to detect and quantify protein solubility in multiple assay formats, both in vitro and in vivo.
Inventors:
;
Issue Date:
OSTI Identifier:
1129021
Assignee:
Los Alamos National Security, LLC (Los Alamos, NM) LANL
Patent Number(s):
8,685,667
Application Number:
13/118,174
Contract Number:
FG02-98ER62647; W-7405-ENG-36
Resource Relation:
Patent File Date: 2011 Mar 27
Research Org:
Los Alamos National Lab. (LANL), Los Alamos, NM (United States)
Sponsoring Org:
USDOE
Country of Publication:
United States
Language:
English
Subject:
59 BASIC BIOLOGICAL SCIENCES

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